The DAR home page (Figure 1) represents the main access point to the database, allowing the user to make queries by different search fields. In particular, using a selection field, the user can choice to search by the following keys:
After selecting the search field, the user can specifiy the serach value in the text area. All the queries support autocompletion (Figure 2), to help the user properly selecting the input values. The query can be submitted using the Search button.
The user can choose to explore the database content by browsing DAR by different entities. Clicking on the BROWSE entry of the menu on top of the page (Figure 3), the user can choose to brwose DAR by:
Clicking on one of the above browse keys, teh user is redirected to a page containing all entries of the selected type contained in DAR. For instance, in Figure 4 it is shown the Browse by Reactome page. Clicking on the Reactome ID, the user is redirected to the corresponding result page (see next section).
Upon query submission, DAR returns to the user a result page (Figure 5) containing a summary table and the data organized in a tabular format. Each row reports a disease-enzyme association alongside several additional information, including:
From the table, clicking on the UniProtKB accession or the gene symbol, the user is redirected on the corresponding UniProtKB page. Clicking on disease ID, Reactome IDs or Reactions, a tooltip opens showing details about all these fields as well as links to reference resources: