DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-977606)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007471	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0008090	ELANE	P08246	3.4.21.37	R-HSA-5620971 R-HSA-5620971 Reactome Name: Pyroptosis See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System Programmed Cell Death Extracellular matrix organization	R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-2482180 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2482180 Reaction Name: Collagen type VIII degradation by ELANE See in Reactome R-HSA-2514823 ( R-HSA-1474228 ) R-HSA-2514823 Reaction Name: Fibrillin-1 degradation by ELANE See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6813659 ( R-HSA-6803157 ) R-HSA-6813659 Reaction Name: ELANE, CTSG or PRTN3 binds bacteria See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9710106 ( R-HSA-5620971 ) R-HSA-9710106 Reaction Name: ELANE cleaves GSDMD See in Reactome
MONDO:0008559	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0008910	CPN1	P15169	3.4.17.3	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-8852809 ( R-HSA-977606 ) R-HSA-8852809 Reaction Name: CPN, CPB2 cleave C3a, C5a See in Reactome
MONDO:0009006	C2	P06681	3.4.21.43	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-166795 ( R-HSA-166663 ) R-HSA-166795 Reaction Name: Formation of Classical C3 convertase (C4b:C2a complex) See in Reactome R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173636 ( R-HSA-174577 ) R-HSA-173636 Reaction Name: Formation of classic pathway C5 convertase See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome R-HSA-981648 ( R-HSA-977606 ) R-HSA-981648 Reaction Name: C4b binding protein binds C4bC2a See in Reactome R-HSA-981680 ( R-HSA-977606 ) R-HSA-981680 Reaction Name: C4b binding protein displaces C2a See in Reactome
MONDO:0012594	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0013041	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0013042	CFB	P00751	3.4.21.47	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-173740 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173740 Reaction Name: Factor B binds to C3(H2O) See in Reactome R-HSA-173745 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-173754 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173754 Reaction Name: Properdin stabilizes C3b:Bb bound to cell surfaces See in Reactome R-HSA-174551 ( R-HSA-166663; R-HSA-173736 ) R-HSA-174551 Reaction Name: Formation of alternative pathway C5 convertase See in Reactome R-HSA-183122 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-183126 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183126 Reaction Name: Factor B binds to surface-associated C3b See in Reactome R-HSA-183130 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183130 Reaction Name: C3(H2O):Factor Bb cleaves C3 to C3b and C3a See in Reactome R-HSA-977363 ( R-HSA-977606 ) R-HSA-977363 Reaction Name: Factor H binds to C3bBb See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977605 ( R-HSA-977606 ) R-HSA-977605 Reaction Name: Factor H displaces Bb See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome
MONDO:0013361	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0013419	C1S	P09871	3.4.21.42	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0013728	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0013743	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0014189	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0014207	CFB	P00751	3.4.21.47	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-173740 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173740 Reaction Name: Factor B binds to C3(H2O) See in Reactome R-HSA-173745 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-173754 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173754 Reaction Name: Properdin stabilizes C3b:Bb bound to cell surfaces See in Reactome R-HSA-174551 ( R-HSA-166663; R-HSA-173736 ) R-HSA-174551 Reaction Name: Formation of alternative pathway C5 convertase See in Reactome R-HSA-183122 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-183126 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183126 Reaction Name: Factor B binds to surface-associated C3b See in Reactome R-HSA-183130 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183130 Reaction Name: C3(H2O):Factor Bb cleaves C3 to C3b and C3a See in Reactome R-HSA-977363 ( R-HSA-977606 ) R-HSA-977363 Reaction Name: Factor H binds to C3bBb See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977605 ( R-HSA-977606 ) R-HSA-977605 Reaction Name: Factor H displaces Bb See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome
MONDO:0014207	C2	P06681	3.4.21.43	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-166795 ( R-HSA-166663 ) R-HSA-166795 Reaction Name: Formation of Classical C3 convertase (C4b:C2a complex) See in Reactome R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173636 ( R-HSA-174577 ) R-HSA-173636 Reaction Name: Formation of classic pathway C5 convertase See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome R-HSA-981648 ( R-HSA-977606 ) R-HSA-981648 Reaction Name: C4b binding protein binds C4bC2a See in Reactome R-HSA-981680 ( R-HSA-977606 ) R-HSA-981680 Reaction Name: C4b binding protein displaces C2a See in Reactome
MONDO:0014255	CFB	P00751	3.4.21.47	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-173740 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173740 Reaction Name: Factor B binds to C3(H2O) See in Reactome R-HSA-173745 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-173754 ( R-HSA-166663; R-HSA-173736 ) R-HSA-173754 Reaction Name: Properdin stabilizes C3b:Bb bound to cell surfaces See in Reactome R-HSA-174551 ( R-HSA-166663; R-HSA-173736 ) R-HSA-174551 Reaction Name: Formation of alternative pathway C5 convertase See in Reactome R-HSA-183122 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-183126 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183126 Reaction Name: Factor B binds to surface-associated C3b See in Reactome R-HSA-183130 ( R-HSA-166663; R-HSA-173736 ) R-HSA-183130 Reaction Name: C3(H2O):Factor Bb cleaves C3 to C3b and C3a See in Reactome R-HSA-977363 ( R-HSA-977606 ) R-HSA-977363 Reaction Name: Factor H binds to C3bBb See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977605 ( R-HSA-977606 ) R-HSA-977605 Reaction Name: Factor H displaces Bb See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome
MONDO:0014954	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0014954	C1S	P09871	3.4.21.42	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0015699	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0020684	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0020684	C1S	P09871	3.4.21.42	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0042490	ELANE	P08246	3.4.21.37	R-HSA-5620971 R-HSA-5620971 Reactome Name: Pyroptosis See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System Programmed Cell Death Extracellular matrix organization	R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-2482180 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2482180 Reaction Name: Collagen type VIII degradation by ELANE See in Reactome R-HSA-2514823 ( R-HSA-1474228 ) R-HSA-2514823 Reaction Name: Fibrillin-1 degradation by ELANE See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6813659 ( R-HSA-6803157 ) R-HSA-6813659 Reaction Name: ELANE, CTSG or PRTN3 binds bacteria See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9710106 ( R-HSA-5620971 ) R-HSA-9710106 Reaction Name: ELANE cleaves GSDMD See in Reactome

Number of enzymes:	8
Number of disease:	19
Number of reactomes:	22
Number of reactions:	77

Search summary (Reactome ID: R-HSA-977606)

Search results (Reactome ID: R-HSA-977606)

MONDO:0007471

R-HSA-977606

R-HSA-168256

R-HSA-168249

R-HSA-166658

R-HSA-3266557

R-HSA-976743

R-HSA-976801

R-HSA-976810

R-HSA-977359

R-HSA-977371

R-HSA-977602

R-HSA-977615

R-HSA-981637

R-HSA-981658

MONDO:0008090

R-HSA-5620971

R-HSA-977606

R-HSA-1474228

R-HSA-1442490

R-HSA-1592389

R-HSA-6803157

R-HSA-6798695

R-HSA-168249

R-HSA-168256

R-HSA-5218859

R-HSA-5357801

R-HSA-1474244

R-HSA-166658

R-HSA-1566962

R-HSA-1592270

R-HSA-1592316

R-HSA-1592398

R-HSA-1604712

R-HSA-2482180

R-HSA-2514823

R-HSA-6798749

R-HSA-6798751

R-HSA-6813659

R-HSA-8852716

R-HSA-9710106

MONDO:0008559

R-HSA-159740

R-HSA-381426

R-HSA-76009

R-HSA-977606

R-HSA-456926

R-HSA-375276

R-HSA-202733

R-HSA-416476

R-HSA-159782

R-HSA-140837

R-HSA-140875

R-HSA-159763

R-HSA-140877

R-HSA-372790

R-HSA-388396

R-HSA-76002

R-HSA-163841

R-HSA-168256

R-HSA-392499

R-HSA-109582

R-HSA-159854

R-HSA-166658

R-HSA-597592

R-HSA-168249

R-HSA-500792

R-HSA-373076

R-HSA-162582

R-HSA-114697

R-HSA-140599

R-HSA-140664

R-HSA-140696

R-HSA-140700

R-HSA-140791

R-HSA-140840

R-HSA-140870

R-HSA-140872