DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-975634)

Number of enzymes:	6
Number of disease:	10
Number of reactomes:	10
Number of reactions:	26

Search results (Reactome ID: R-HSA-975634)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007272	BCO1	Q9HAY6	1.13.11.63	R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome	Metabolism Sensory Perception	R-HSA-975635 ( R-HSA-975634 ) R-HSA-975635 Reaction Name: BCMO1:Fe2+ cleaves betaC to atRAL See in Reactome
MONDO:0007759	LPL	P06858	3.1.1.34 3.1.1.32	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8963901 R-HSA-8963901 Reactome Name: Chylomicron remodeling See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Sensory Perception Metabolism Developmental Biology	R-HSA-174757 ( R-HSA-8963901 ) R-HSA-174757 Reaction Name: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols See in Reactome R-HSA-2395768 ( R-HSA-975634 ) R-HSA-2395768 Reaction Name: LPL hydrolyses TGs from mature CMs See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-6784628 ( R-HSA-8963889 ) R-HSA-6784628 Reaction Name: PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784676 ( R-HSA-8963889 ) R-HSA-6784676 Reaction Name: PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784861 ( R-HSA-8963889 ) R-HSA-6784861 Reaction Name: HSPG binds LPL dimer See in Reactome R-HSA-8857928 ( R-HSA-8963889 ) R-HSA-8857928 Reaction Name: GPIHBP1 binds HSPG:LPL dimer See in Reactome
MONDO:0008764	LRAT	O95237	2.3.1.135	R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome	Metabolism Sensory Perception	R-HSA-2404137 ( R-HSA-975634 ) R-HSA-2404137 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-2453855 ( R-HSA-2453902 ) R-HSA-2453855 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-975608 ( R-HSA-975634 ) R-HSA-975608 Reaction Name: LRAT esterifies RBP2:atROL and FACYLs to atREs See in Reactome
MONDO:0009387	LPL	P06858	3.1.1.34 3.1.1.32	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8963901 R-HSA-8963901 Reactome Name: Chylomicron remodeling See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Sensory Perception Metabolism Developmental Biology	R-HSA-174757 ( R-HSA-8963901 ) R-HSA-174757 Reaction Name: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols See in Reactome R-HSA-2395768 ( R-HSA-975634 ) R-HSA-2395768 Reaction Name: LPL hydrolyses TGs from mature CMs See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-6784628 ( R-HSA-8963889 ) R-HSA-6784628 Reaction Name: PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784676 ( R-HSA-8963889 ) R-HSA-6784676 Reaction Name: PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784861 ( R-HSA-8963889 ) R-HSA-6784861 Reaction Name: HSPG binds LPL dimer See in Reactome R-HSA-8857928 ( R-HSA-8963889 ) R-HSA-8857928 Reaction Name: GPIHBP1 binds HSPG:LPL dimer See in Reactome
MONDO:0009549	LRAT	O95237	2.3.1.135	R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome	Metabolism Sensory Perception	R-HSA-2404137 ( R-HSA-975634 ) R-HSA-2404137 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-2453855 ( R-HSA-2453902 ) R-HSA-2453855 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-975608 ( R-HSA-975634 ) R-HSA-975608 Reaction Name: LRAT esterifies RBP2:atROL and FACYLs to atREs See in Reactome
MONDO:0013231	LRAT	O95237	2.3.1.135	R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome	Metabolism Sensory Perception	R-HSA-2404137 ( R-HSA-975634 ) R-HSA-2404137 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-2453855 ( R-HSA-2453902 ) R-HSA-2453855 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-975608 ( R-HSA-975634 ) R-HSA-975608 Reaction Name: LRAT esterifies RBP2:atROL and FACYLs to atREs See in Reactome
MONDO:0013664	AKR1C4	P17516	1.1.1.62 1.1.1.- 1.1.1.357 1.1.1.209 1.1.1.53 1.1.1.51 1.1.1.225 1.1.1.210	R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Sensory Perception Metabolism	R-HSA-192036 ( R-HSA-193368 ) R-HSA-192036 Reaction Name: 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol See in Reactome R-HSA-192160 ( R-HSA-193368 ) R-HSA-192160 Reaction Name: 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol See in Reactome R-HSA-193758 ( R-HSA-193775 ) R-HSA-193758 Reaction Name: 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol See in Reactome R-HSA-193781 ( R-HSA-193775 ) R-HSA-193781 Reaction Name: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol See in Reactome R-HSA-193800 ( R-HSA-193807 ) R-HSA-193800 Reaction Name: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol See in Reactome R-HSA-193841 ( R-HSA-193807 ) R-HSA-193841 Reaction Name: 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol See in Reactome R-HSA-2855252 ( R-HSA-975634 ) R-HSA-2855252 Reaction Name: AKRs reduce RBP2:atRAL to RBP2:atROL See in Reactome
MONDO:0013700	PNLIP	P16233	3.1.1.3	R-HSA-192456 R-HSA-192456 Reactome Name: Digestion of dietary lipid See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	Sensory Perception Digestion and absorption Metabolism	R-HSA-192422 ( R-HSA-192456 ) R-HSA-192422 Reaction Name: Digestion of triacylglycerols by extracellular PTL:colipase See in Reactome R-HSA-192434 ( R-HSA-192456 ) R-HSA-192434 Reaction Name: Digestion of diacylglycerols by extracellular PTL:colipase See in Reactome R-HSA-192475 ( R-HSA-192456 ) R-HSA-192475 Reaction Name: Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 See in Reactome R-HSA-975593 ( R-HSA-192456; R-HSA-975634 ) R-HSA-975593 Reaction Name: PNLIP:CLPS hydrolyses RPALM to atROL and PALM See in Reactome
MONDO:0014495	RDH11	Q8TC12	1.1.1.300	R-HSA-5365859 R-HSA-5365859 Reactome Name: RA biosynthesis pathway See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	Sensory Perception Metabolism Signal Transduction	R-HSA-5362721 ( R-HSA-5365859 ) R-HSA-5362721 Reaction Name: RDH5,RDH11 oxidise 11cROL to 11cRAL See in Reactome R-HSA-5419165 ( R-HSA-5365859 ) R-HSA-5419165 Reaction Name: RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL See in Reactome R-HSA-74872 ( R-HSA-2453902 ) R-HSA-74872 Reaction Name: RDH10,11 oxidise 11cROL to 11cRAL See in Reactome R-HSA-975629 ( R-HSA-975634 ) R-HSA-975629 Reaction Name: RDH11 reduces RBP2:atRAL to RBP2:atROL See in Reactome
MONDO:0019200	LRAT	O95237	2.3.1.135	R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome	Metabolism Sensory Perception	R-HSA-2404137 ( R-HSA-975634 ) R-HSA-2404137 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-2453855 ( R-HSA-2453902 ) R-HSA-2453855 Reaction Name: LRAT esterifies RBP1:atROL and FACYLs to atREs See in Reactome R-HSA-975608 ( R-HSA-975634 ) R-HSA-975608 Reaction Name: LRAT esterifies RBP2:atROL and FACYLs to atREs See in Reactome