DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-975138)

Number of enzymes:	3
Number of disease:	3
Number of reactomes:	33
Number of reactions:	143

Search results (Reactome ID: R-HSA-975138)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011888	IRAK4	Q9NWZ3	2.7.11.1	R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975110 R-HSA-975110 Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome	R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System Signal Transduction	R-HSA-166082 ( R-HSA-166058 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-446634 ( R-HSA-9020702 ) R-HSA-446634 Reaction Name: IRAK4 is activated by autophosphorylation See in Reactome R-HSA-446648 ( R-HSA-9020702 ) R-HSA-446648 Reaction Name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 See in Reactome R-HSA-446684 ( R-HSA-9020702 ) R-HSA-446684 Reaction Name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation See in Reactome R-HSA-446692 ( R-HSA-9020702 ) R-HSA-446692 Reaction Name: IRAK1 binds to MYD88 within the IL1R complex See in Reactome R-HSA-446694 ( R-HSA-9020702 ) R-HSA-446694 Reaction Name: IRAK4 phosphorylates IRAK1 See in Reactome R-HSA-446701 ( R-HSA-9020702 ) R-HSA-446701 Reaction Name: IRAK4-activated IRAK1 autophosphorylates See in Reactome R-HSA-446862 ( R-HSA-9020702 ) R-HSA-446862 Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6 See in Reactome R-HSA-446868 ( R-HSA-9020702 ) R-HSA-446868 Reaction Name: The Interleukin 1 receptor complex binds Tollip See in Reactome R-HSA-446894 ( R-HSA-9020702 ) R-HSA-446894 Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release See in Reactome R-HSA-450690 ( R-HSA-9020702 ) R-HSA-450690 Reaction Name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 See in Reactome R-HSA-450827 ( R-HSA-9020702 ) R-HSA-450827 Reaction Name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. See in Reactome R-HSA-8948063 ( R-HSA-9020702 ) R-HSA-8948063 Reaction Name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 See in Reactome R-HSA-937022 ( R-HSA-166058 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-975100 ( R-HSA-975138; R-HSA-975155 ) R-HSA-975100 Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex See in Reactome R-HSA-975106 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975106 Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975111 ( R-HSA-975155 ) R-HSA-975111 Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975115 ( R-HSA-975155 ) R-HSA-975115 Reaction Name: IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. See in Reactome R-HSA-975118 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975118 Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex See in Reactome R-HSA-975125 ( R-HSA-975155 ) R-HSA-975125 Reaction Name: Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975134 ( R-HSA-975155 ) R-HSA-975134 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 See in Reactome R-HSA-975156 ( R-HSA-975155 ) R-HSA-975156 Reaction Name: IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex See in Reactome R-HSA-975160 ( R-HSA-975155 ) R-HSA-975160 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 See in Reactome R-HSA-975170 ( R-HSA-975155 ) R-HSA-975170 Reaction Name: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 See in Reactome R-HSA-975180 ( R-HSA-975155 ) R-HSA-975180 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 See in Reactome R-HSA-975188 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975188 Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975852 ( R-HSA-975871 ) R-HSA-975852 Reaction Name: IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex See in Reactome R-HSA-975853 ( R-HSA-975871 ) R-HSA-975853 Reaction Name: Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR See in Reactome R-HSA-975857 ( R-HSA-975871 ) R-HSA-975857 Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2 See in Reactome R-HSA-975861 ( R-HSA-975871 ) R-HSA-975861 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex See in Reactome R-HSA-975865 ( R-HSA-975871 ) R-HSA-975865 Reaction Name: IRAK4 autophosphorylation within the complex activated TLR:MyD88 See in Reactome R-HSA-975873 ( R-HSA-975871 ) R-HSA-975873 Reaction Name: IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor See in Reactome R-HSA-975874 ( R-HSA-975871 ) R-HSA-975874 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex See in Reactome R-HSA-975878 ( R-HSA-975871 ) R-HSA-975878 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR See in Reactome R-HSA-975879 ( R-HSA-975871 ) R-HSA-975879 Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex See in Reactome
MONDO:0013410	MAP3K1	Q13233	2.7.11.25	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome	R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System	R-HSA-166869 ( R-HSA-166058; R-HSA-975138; R-HSA-975871 ) R-HSA-166869 Reaction Name: TRAF6 binds MEKK1 See in Reactome R-HSA-2730868 ( R-HSA-2871796 ) R-HSA-2730868 Reaction Name: Phosphorylation of MEK7 by MEKK1 See in Reactome R-HSA-2730887 ( R-HSA-2871796 ) R-HSA-2730887 Reaction Name: Autophosphorylation and activation of MEKK1 See in Reactome R-HSA-2730896 ( R-HSA-2871796 ) R-HSA-2730896 Reaction Name: Phosphorylation of MEK4 by MEKK1 See in Reactome R-HSA-933528 ( R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome
MONDO:0015884	TRAF6	Q9Y4K3	2.3.2.27	R-HSA-937042 R-HSA-937042 Reactome Name: IRAK2 mediated activation of TAK1 complex See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-937072 R-HSA-937072 Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975163 R-HSA-975163 Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-450321 R-HSA-450321 Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-450302 R-HSA-450302 Reactome Name: activated TAK1 mediates p38 MAPK activation See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-9645460 R-HSA-9645460 Reactome Name: Alpha-protein kinase 1 signaling pathway See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975110 R-HSA-975110 Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-9014325 R-HSA-9014325 Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-166869 ( R-HSA-166058; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-166869 Reaction Name: TRAF6 binds MEKK1 See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168915 ( R-HSA-937041 ) R-HSA-168915 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-177690 ( R-HSA-9014325 ) R-HSA-177690 Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-177692 ( R-HSA-9014325 ) R-HSA-177692 Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex See in Reactome R-HSA-177694 ( R-HSA-9014325 ) R-HSA-177694 Reaction Name: Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193665 ( R-HSA-209543 ) R-HSA-193665 Reaction Name: MYD88 dissociates See in Reactome R-HSA-193669 ( R-HSA-205043 ) R-HSA-193669 Reaction Name: TRAF6 binds to p75NTR:NRIF See in Reactome R-HSA-193684 ( R-HSA-209543 ) R-HSA-193684 Reaction Name: p62 recruits an atypical PKC See in Reactome R-HSA-193694 ( R-HSA-209543 ) R-HSA-193694 Reaction Name: p62 is recruited and forms a complex with TRAF6 See in Reactome R-HSA-193695 ( R-HSA-209543 ) R-HSA-193695 Reaction Name: IRAK interacts with TRAF6 See in Reactome R-HSA-193700 ( R-HSA-193692 ) R-HSA-193700 Reaction Name: p75NTR ICD signals to NF-kB See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202453 ( R-HSA-202424 ) R-HSA-202453 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-202472 ( R-HSA-202424 ) R-HSA-202472 Reaction Name: Translocation of TRAF6 to CBM complex See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-204949 ( R-HSA-205043 ) R-HSA-204949 Reaction Name: NRIF and TRAF6 may activate JNK See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-205118 ( R-HSA-205043 ) R-HSA-205118 Reaction Name: TRAF6 polyubiquitinates NRIF See in Reactome R-HSA-209566 ( R-HSA-209543 ) R-HSA-209566 Reaction Name: TRAF6 is auto-ubiquitinated See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730864 ( R-HSA-2871837 ) R-HSA-2730864 Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-2730903 ( R-HSA-2871837 ) R-HSA-2730903 Reaction Name: Oligomerization of TRAF6 See in Reactome R-HSA-2730904 ( R-HSA-2871837 ) R-HSA-2730904 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-446862 ( R-HSA-9020702 ) R-HSA-446862 Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6 See in Reactome R-HSA-446870 ( R-HSA-9020702 ) R-HSA-446870 Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex See in Reactome R-HSA-446877 ( R-HSA-9020702 ) R-HSA-446877 Reaction Name: TRAF6 is K63 poly-ubiquitinated See in Reactome R-HSA-446894 ( R-HSA-9020702 ) R-HSA-446894 Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release See in Reactome R-HSA-450173 ( R-HSA-9020702 ) R-HSA-450173 Reaction Name: IRAK1 induces oligomerisation of TRAF6 See in Reactome R-HSA-450187 ( R-HSA-9020702 ) R-HSA-450187 Reaction Name: TAK1 is activated within the TAK1 complex See in Reactome R-HSA-450259 ( R-HSA-9014325 ) R-HSA-450259 Reaction Name: Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex See in Reactome R-HSA-450337 ( R-HSA-166058; R-HSA-450321; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450337 Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7 See in Reactome R-HSA-450346 ( R-HSA-166058; R-HSA-450302; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450346 Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6 See in Reactome R-HSA-450358 ( R-HSA-937072; R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-450358 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation See in Reactome R-HSA-507719 ( R-HSA-9020702 ) R-HSA-507719 Reaction Name: p62:MEKK3 binds to TRAF6 See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607747 ( R-HSA-5607764 ) R-HSA-5607747 Reaction Name: TRAF6 binds MALT1 oligomers See in Reactome R-HSA-5607751 ( R-HSA-5607764 ) R-HSA-5607751 Reaction Name: TRAF6 oligomerizes See in Reactome R-HSA-5607756 ( R-HSA-5607764 ) R-HSA-5607756 Reaction Name: TRAF6 oligomer autoubiquitinates See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-5690870 ( R-HSA-5689896 ) R-HSA-5690870 Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6 See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-688137 ( R-HSA-168638 ) R-HSA-688137 Reaction Name: RIP2 is K63 polyubiquitinated See in Reactome R-HSA-741386 ( R-HSA-168638 ) R-HSA-741386 Reaction Name: RIP2 induces K63-linked ubiquitination of NEMO See in Reactome R-HSA-847070 ( R-HSA-9014325 ) R-HSA-847070 Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex See in Reactome R-HSA-8869456 ( R-HSA-5689880 ) R-HSA-8869456 Reaction Name: USP4 deubiquitinate TRAF2,TRAF6 See in Reactome R-HSA-8869506 ( R-HSA-5689896 ) R-HSA-8869506 Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 See in Reactome R-HSA-8948015 ( R-HSA-9020702 ) R-HSA-8948015 Reaction Name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb See in Reactome R-HSA-8948018 ( R-HSA-9020702 ) R-HSA-8948018 Reaction Name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 See in Reactome R-HSA-9014342 ( R-HSA-168927 ) R-HSA-9014342 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-918230 ( R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-933525 ( R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933537 ( R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936942 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936942 Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 See in Reactome R-HSA-936947 ( R-HSA-937072 ) R-HSA-936947 Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-936951 ( R-HSA-937072 ) R-HSA-936951 Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex See in Reactome R-HSA-936952 ( R-HSA-937072 ) R-HSA-936952 Reaction Name: Auto ubiquitination of TRAF6 bound to the activated TLR4 complex See in Reactome R-HSA-936960 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936960 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex See in Reactome R-HSA-936963 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936963 Reaction Name: IRAK2 induces TRAF6 oligomerization See in Reactome R-HSA-936985 ( R-HSA-937072 ) R-HSA-936985 Reaction Name: Activated TLR4:TICAM1 recruits TRAF6 See in Reactome R-HSA-936986 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936986 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains See in Reactome R-HSA-936991 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936991 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 See in Reactome R-HSA-937032 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-937034 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937034 Reaction Name: IRAK1 phosphorylates Pellino See in Reactome R-HSA-937044 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937044 Reaction Name: Pellino binds hp-IRAK1:TRAF6 See in Reactome R-HSA-937050 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937050 Reaction Name: Pellino ubiquitinates hp-IRAK1 See in Reactome R-HSA-937075 ( R-HSA-937072 ) R-HSA-937075 Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex See in Reactome R-HSA-9628444 ( R-HSA-9014325 ) R-HSA-9628444 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation See in Reactome R-HSA-9645394 ( R-HSA-9645460 ) R-HSA-9645394 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation See in Reactome R-HSA-9645406 ( R-HSA-9645460 ) R-HSA-9645406 Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) See in Reactome R-HSA-9645414 ( R-HSA-9645460 ) R-HSA-9645414 Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer See in Reactome R-HSA-9645442 ( R-HSA-9645460 ) R-HSA-9645442 Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex See in Reactome R-HSA-9645501 ( R-HSA-9645460 ) R-HSA-9645501 Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex See in Reactome R-HSA-9645520 ( R-HSA-9645460 ) R-HSA-9645520 Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 See in Reactome R-HSA-9705145 ( R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705323 ( R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-975097 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975097 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975100 ( R-HSA-975138; R-HSA-975155 ) R-HSA-975100 Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex See in Reactome R-HSA-975103 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975103 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation See in Reactome R-HSA-975106 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975106 Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975111 ( R-HSA-975155 ) R-HSA-975111 Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975118 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975118 Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex See in Reactome R-HSA-975119 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome R-HSA-975122 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975122 Reaction Name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> See in Reactome R-HSA-975139 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975139 Reaction Name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation See in Reactome R-HSA-975142 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975142 Reaction Name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation See in Reactome R-HSA-975147 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975147 Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane See in Reactome R-HSA-975185 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975185 Reaction Name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments See in Reactome R-HSA-975188 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975188 Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975857 ( R-HSA-975871 ) R-HSA-975857 Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2 See in Reactome R-HSA-975879 ( R-HSA-975871 ) R-HSA-975879 Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex See in Reactome