DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9696264)

Number of enzymes:	2
Number of disease:	7
Number of reactomes:	24
Number of reactions:	41

Search results (Reactome ID: R-HSA-9696264)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005138	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome
MONDO:0007288	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0018610	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0020376	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0020378	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0021100	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome
MONDO:0021548	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome