DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9652282)

Number of enzymes:	1
Number of disease:	5
Number of reactomes:	16
Number of reactions:	43

Search results (Reactome ID: R-HSA-9652282)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001056	ERBB2	P04626	2.7.10.1	R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1306955 R-HSA-1306955 Reactome Name: GRB7 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-9652282 R-HSA-9652282 Reactome Name: Drug-mediated inhibition of ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306953 ( R-HSA-1227986; R-HSA-1306955 ) R-HSA-1306953 Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1358792 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358792 Reaction Name: RNF41 ubiquitinates activated ERBB3 See in Reactome R-HSA-1358798 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358798 Reaction Name: RNF41 binds neuregulin-activated ERBB3 See in Reactome R-HSA-1918092 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-1918095 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918095 Reaction Name: CUL5 mediates ubiquitination of ERBB2 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-373750 ( R-HSA-416572 ) R-HSA-373750 Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2 See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-416594 ( R-HSA-416572 ) R-HSA-416594 Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8864466 ( R-HSA-8866910 ) R-HSA-8864466 Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression See in Reactome R-HSA-9652264 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652264 Reaction Name: ERBB2 binds TKIs See in Reactome R-HSA-9652277 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652277 Reaction Name: ERBB2 binds trastuzumab See in Reactome R-HSA-9665726 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9665726 Reaction Name: ERBB2 binds pertuzumab See in Reactome
MONDO:0008170	ERBB2	P04626	2.7.10.1	R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1306955 R-HSA-1306955 Reactome Name: GRB7 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-9652282 R-HSA-9652282 Reactome Name: Drug-mediated inhibition of ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306953 ( R-HSA-1227986; R-HSA-1306955 ) R-HSA-1306953 Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1358792 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358792 Reaction Name: RNF41 ubiquitinates activated ERBB3 See in Reactome R-HSA-1358798 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358798 Reaction Name: RNF41 binds neuregulin-activated ERBB3 See in Reactome R-HSA-1918092 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-1918095 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918095 Reaction Name: CUL5 mediates ubiquitination of ERBB2 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-373750 ( R-HSA-416572 ) R-HSA-373750 Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2 See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-416594 ( R-HSA-416572 ) R-HSA-416594 Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8864466 ( R-HSA-8866910 ) R-HSA-8864466 Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression See in Reactome R-HSA-9652264 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652264 Reaction Name: ERBB2 binds TKIs See in Reactome R-HSA-9652277 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652277 Reaction Name: ERBB2 binds trastuzumab See in Reactome R-HSA-9665726 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9665726 Reaction Name: ERBB2 binds pertuzumab See in Reactome
MONDO:0008903	ERBB2	P04626	2.7.10.1	R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1306955 R-HSA-1306955 Reactome Name: GRB7 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-9652282 R-HSA-9652282 Reactome Name: Drug-mediated inhibition of ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306953 ( R-HSA-1227986; R-HSA-1306955 ) R-HSA-1306953 Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1358792 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358792 Reaction Name: RNF41 ubiquitinates activated ERBB3 See in Reactome R-HSA-1358798 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358798 Reaction Name: RNF41 binds neuregulin-activated ERBB3 See in Reactome R-HSA-1918092 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-1918095 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918095 Reaction Name: CUL5 mediates ubiquitination of ERBB2 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-373750 ( R-HSA-416572 ) R-HSA-373750 Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2 See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-416594 ( R-HSA-416572 ) R-HSA-416594 Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8864466 ( R-HSA-8866910 ) R-HSA-8864466 Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression See in Reactome R-HSA-9652264 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652264 Reaction Name: ERBB2 binds TKIs See in Reactome R-HSA-9652277 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652277 Reaction Name: ERBB2 binds trastuzumab See in Reactome R-HSA-9665726 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9665726 Reaction Name: ERBB2 binds pertuzumab See in Reactome
MONDO:0018309	ERBB2	P04626	2.7.10.1	R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1306955 R-HSA-1306955 Reactome Name: GRB7 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-9652282 R-HSA-9652282 Reactome Name: Drug-mediated inhibition of ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306953 ( R-HSA-1227986; R-HSA-1306955 ) R-HSA-1306953 Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1358792 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358792 Reaction Name: RNF41 ubiquitinates activated ERBB3 See in Reactome R-HSA-1358798 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358798 Reaction Name: RNF41 binds neuregulin-activated ERBB3 See in Reactome R-HSA-1918092 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-1918095 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918095 Reaction Name: CUL5 mediates ubiquitination of ERBB2 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-373750 ( R-HSA-416572 ) R-HSA-373750 Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2 See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-416594 ( R-HSA-416572 ) R-HSA-416594 Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8864466 ( R-HSA-8866910 ) R-HSA-8864466 Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression See in Reactome R-HSA-9652264 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652264 Reaction Name: ERBB2 binds TKIs See in Reactome R-HSA-9652277 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652277 Reaction Name: ERBB2 binds trastuzumab See in Reactome R-HSA-9665726 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9665726 Reaction Name: ERBB2 binds pertuzumab See in Reactome
MONDO:0024498	ERBB2	P04626	2.7.10.1	R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1306955 R-HSA-1306955 Reactome Name: GRB7 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-9652282 R-HSA-9652282 Reactome Name: Drug-mediated inhibition of ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306953 ( R-HSA-1227986; R-HSA-1306955 ) R-HSA-1306953 Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1358792 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358792 Reaction Name: RNF41 ubiquitinates activated ERBB3 See in Reactome R-HSA-1358798 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358798 Reaction Name: RNF41 binds neuregulin-activated ERBB3 See in Reactome R-HSA-1918092 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-1918095 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1918095 Reaction Name: CUL5 mediates ubiquitination of ERBB2 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-373750 ( R-HSA-416572 ) R-HSA-373750 Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2 See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-416594 ( R-HSA-416572 ) R-HSA-416594 Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8864466 ( R-HSA-8866910 ) R-HSA-8864466 Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression See in Reactome R-HSA-9652264 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652264 Reaction Name: ERBB2 binds TKIs See in Reactome R-HSA-9652277 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9652277 Reaction Name: ERBB2 binds trastuzumab See in Reactome R-HSA-9665726 ( R-HSA-1227986; R-HSA-9652282 ) R-HSA-9665726 Reaction Name: ERBB2 binds pertuzumab See in Reactome