DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9633012)

Number of enzymes:	3
Number of disease:	4
Number of reactomes:	12
Number of reactions:	23

Search results (Reactome ID: R-HSA-9633012)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009329	EIF2AK4	Q9P2K8	2.7.11.1	R-HSA-9633012 R-HSA-9633012 Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency See in Reactome	R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome	Cellular responses to stimuli	R-HSA-9633005 ( R-HSA-9633012 ) R-HSA-9633005 Reaction Name: EIF2AK4 (GCN2) binds tRNA See in Reactome R-HSA-9633008 ( R-HSA-9633012 ) R-HSA-9633008 Reaction Name: p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 See in Reactome R-HSA-9633742 ( R-HSA-9633012 ) R-HSA-9633742 Reaction Name: EIF2AK4 (GCN2) dimer autophosphorylates See in Reactome
MONDO:0010258	EIF2S3	P41091	3.6.5.3	R-HSA-72695 R-HSA-72695 Reactome Name: Formation of the ternary complex, and subsequently, the 43S complex See in Reactome R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-72649 R-HSA-72649 Reactome Name: Translation initiation complex formation See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-9633012 R-HSA-9633012 Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency See in Reactome R-HSA-156827 R-HSA-156827 Reactome Name: L13a-mediated translational silencing of Ceruloplasmin expression See in Reactome R-HSA-72731 R-HSA-72731 Reactome Name: Recycling of eIF2:GDP See in Reactome R-HSA-72702 R-HSA-72702 Reactome Name: Ribosomal scanning and start codon recognition See in Reactome R-HSA-72706 R-HSA-72706 Reactome Name: GTP hydrolysis and joining of the 60S ribosomal subunit See in Reactome R-HSA-9648895 R-HSA-9648895 Reactome Name: Response of EIF2AK1 (HRI) to heme deficiency See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-72662 R-HSA-72662 Reactome Name: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S See in Reactome R-HSA-72613 R-HSA-72613 Reactome Name: Eukaryotic Translation Initiation See in Reactome R-HSA-72737 R-HSA-72737 Reactome Name: Cap-dependent Translation Initiation See in Reactome	Cellular responses to stimuli Transport of small molecules Metabolism of proteins	R-HSA-156808 ( R-HSA-72649 ) R-HSA-156808 Reaction Name: Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation See in Reactome R-HSA-156823 ( R-HSA-156827 ) R-HSA-156823 Reaction Name: Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA See in Reactome R-HSA-157849 ( R-HSA-72649 ) R-HSA-157849 Reaction Name: Formation of translation initiation complexes containing mRNA that does not circularize See in Reactome R-HSA-381111 ( R-HSA-381042 ) R-HSA-381111 Reaction Name: EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK See in Reactome R-HSA-381128 ( R-HSA-381042; R-HSA-9633012; R-HSA-9648895 ) R-HSA-381128 Reaction Name: Translation of ATF4 See in Reactome R-HSA-5227009 ( R-HSA-382556 ) R-HSA-5227009 Reaction Name: ABCF1 binds EIF2 See in Reactome R-HSA-72619 ( R-HSA-72706 ) R-HSA-72619 Reaction Name: eIF2:GTP is hydrolyzed, eIFs are released See in Reactome R-HSA-72621 ( R-HSA-72702 ) R-HSA-72621 Reaction Name: Ribosomal scanning See in Reactome R-HSA-72663 ( R-HSA-72695 ) R-HSA-72663 Reaction Name: De novo formation of eIF2:GTP See in Reactome R-HSA-72669 ( R-HSA-72695 ) R-HSA-72669 Reaction Name: Met-tRNAi binds to eIF2:GTP to form the ternary complex See in Reactome R-HSA-72670 ( R-HSA-72731 ) R-HSA-72670 Reaction Name: Formation of eIF2:GDP:eIF2B intermediate See in Reactome R-HSA-72691 ( R-HSA-72695 ) R-HSA-72691 Reaction Name: Formation of the 43S pre-initiation complex See in Reactome R-HSA-72697 ( R-HSA-72702 ) R-HSA-72697 Reaction Name: Start codon recognition See in Reactome R-HSA-72722 ( R-HSA-72731 ) R-HSA-72722 Reaction Name: eIF2 activation See in Reactome R-HSA-9633008 ( R-HSA-9633012 ) R-HSA-9633008 Reaction Name: p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 See in Reactome R-HSA-9648888 ( R-HSA-9648895 ) R-HSA-9648888 Reaction Name: p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) See in Reactome R-HSA-9650710 ( R-HSA-9648895 ) R-HSA-9650710 Reaction Name: Translation of PPP1R15A See in Reactome R-HSA-9650722 ( R-HSA-9633012; R-HSA-9648895 ) R-HSA-9650722 Reaction Name: Translation of DDIT3 See in Reactome R-HSA-9653745 ( R-HSA-9648895 ) R-HSA-9653745 Reaction Name: Translation of ATF5 See in Reactome
MONDO:0014258	ASNS	P08243	6.3.5.4	R-HSA-9633012 R-HSA-9633012 Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-9648895 R-HSA-9648895 Reactome Name: Response of EIF2AK1 (HRI) to heme deficiency See in Reactome R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome	Cellular responses to stimuli Metabolism	R-HSA-1791118 ( R-HSA-380994; R-HSA-381042; R-HSA-9633012; R-HSA-9648895 ) R-HSA-1791118 Reaction Name: Expression of ASNS (Asparagine Synthetase) See in Reactome R-HSA-70599 ( R-HSA-8963693 ) R-HSA-70599 Reaction Name: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] See in Reactome
MONDO:0017148	EIF2AK4	Q9P2K8	2.7.11.1	R-HSA-9633012 R-HSA-9633012 Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency See in Reactome	R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome	Cellular responses to stimuli	R-HSA-9633005 ( R-HSA-9633012 ) R-HSA-9633005 Reaction Name: EIF2AK4 (GCN2) binds tRNA See in Reactome R-HSA-9633008 ( R-HSA-9633012 ) R-HSA-9633008 Reaction Name: p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 See in Reactome R-HSA-9633742 ( R-HSA-9633012 ) R-HSA-9633742 Reaction Name: EIF2AK4 (GCN2) dimer autophosphorylates See in Reactome