DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9615017)

Number of enzymes:	6
Number of disease:	14
Number of reactomes:	13
Number of reactions:	32

Search results (Reactome ID: R-HSA-9615017)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0004946	G6PC1	P35575	3.1.3.9	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-71825 ( R-HSA-70263 ) R-HSA-71825 Reaction Name: G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) See in Reactome R-HSA-9623192 ( R-HSA-9615017 ) R-HSA-9623192 Reaction Name: G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 See in Reactome
MONDO:0005148	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0005406	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0007453	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0009287	G6PC1	P35575	3.1.3.9	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-71825 ( R-HSA-70263 ) R-HSA-71825 Reaction Name: G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) See in Reactome R-HSA-9623192 ( R-HSA-9615017 ) R-HSA-9623192 Reaction Name: G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 See in Reactome
MONDO:0009866	PCK1	P35558	4.1.1.32 2.7.11.-	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9632974 R-HSA-9632974 Reactome Name: NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Signal Transduction Developmental Biology	R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-70241 ( R-HSA-70263 ) R-HSA-70241 Reaction Name: oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] See in Reactome R-HSA-9605051 ( R-HSA-9632974 ) R-HSA-9605051 Reaction Name: Expression of PCK1 regulated by NR1H3 See in Reactome R-HSA-9623280 ( R-HSA-9615017 ) R-HSA-9623280 Reaction Name: PCK1 gene expression is stimulated by FOXO1:PPARGC1A See in Reactome
MONDO:0011236	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0012970	SOD2	P04179	1.15.1.1	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Organelle biogenesis and maintenance Immune System	R-HSA-3299680 ( R-HSA-3299685 ) R-HSA-3299680 Reaction Name: SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617941 ( R-HSA-8950505 ) R-HSA-9617941 Reaction Name: Expression of superoxide dismutase 2 See in Reactome
MONDO:0013571	CAT	P04040	1.11.1.6	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Protein localization Immune System Gene expression (Transcription)	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-76031 ( R-HSA-3299685 ) R-HSA-76031 Reaction Name: 2 H2O2 => O2 + 2 H2O See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome R-HSA-9622738 ( R-HSA-9615017 ) R-HSA-9622738 Reaction Name: CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) See in Reactome
MONDO:0015967	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0017174	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0017175	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0017176	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0100165	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome