MONDO:0000087 |
MONDO:0000087
Disease Name: polymicrogyria
Orphanet id: Orphanet:35981
All associated enzymes in DAR:
AKT3
. The disease is also associated to other non-enzyme proteins (not in DAR).
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399;
R-HSA-74751
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0001187 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0001187 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0002049 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0002407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005012 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005062 |
MONDO:0005062
Disease Name: lymphoma
OMIM id: OMIM:605027
Orphanet id: Orphanet:223735
All associated enzymes in DAR:
PTPN11
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0005148 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-165158;
R-HSA-74751
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-165158;
R-HSA-74751
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-165160;
R-HSA-74751
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005223 |
FLT3 |
P36888 |
2.7.10.1
|
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-1257604
R-HSA-9645135
R-HSA-9706369
R-HSA-109704
R-HSA-9607240
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-168256
R-HSA-112399
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6786789
(
R-HSA-9607240
)
R-HSA-8854736
(
R-HSA-9607240
)
R-HSA-9604738
(
R-HSA-9607240
)
R-HSA-9604767
(
R-HSA-9607240
)
R-HSA-9604767
Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9605259
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9606622
(
R-HSA-9607240
)
R-HSA-9606622
Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
See in Reactome
R-HSA-9606624
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9607224
(
R-HSA-9607240
)
R-HSA-9607224
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
See in Reactome
R-HSA-9607301
(
R-HSA-9607240
)
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9609274
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9695828
(
R-HSA-9607240
)
R-HSA-9695831
(
R-HSA-9607240
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9698408
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9698408
Reaction Name: PTPRJ dephosphorylates active FLT3
See in Reactome
R-HSA-9699578
(
R-HSA-9607240
)
R-HSA-9699578
Reaction Name: Active FLT3 phosphorylates CDKN1B
See in Reactome
R-HSA-9706287
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706293
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706298
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706304
(
R-HSA-9607240
)
R-HSA-9706308
(
R-HSA-9607240
)
R-HSA-9706312
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706315
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706319
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706323
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706328
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706330
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706340
(
R-HSA-9607240
)
R-HSA-9706340
Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1
See in Reactome
R-HSA-9706344
(
R-HSA-9607240
)
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706350
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
Reaction Name: Internalization of ubiquitinated FLT3
See in Reactome
|
MONDO:0005224 |
FLT3 |
P36888 |
2.7.10.1
|
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-1257604
R-HSA-9645135
R-HSA-9706369
R-HSA-109704
R-HSA-9607240
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-168256
R-HSA-112399
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6786789
(
R-HSA-9607240
)
R-HSA-8854736
(
R-HSA-9607240
)
R-HSA-9604738
(
R-HSA-9607240
)
R-HSA-9604767
(
R-HSA-9607240
)
R-HSA-9604767
Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9605259
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9606622
(
R-HSA-9607240
)
R-HSA-9606622
Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
See in Reactome
R-HSA-9606624
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9607224
(
R-HSA-9607240
)
R-HSA-9607224
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
See in Reactome
R-HSA-9607301
(
R-HSA-9607240
)
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9609274
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9695828
(
R-HSA-9607240
)
R-HSA-9695831
(
R-HSA-9607240
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9698408
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9698408
Reaction Name: PTPRJ dephosphorylates active FLT3
See in Reactome
R-HSA-9699578
(
R-HSA-9607240
)
R-HSA-9699578
Reaction Name: Active FLT3 phosphorylates CDKN1B
See in Reactome
R-HSA-9706287
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706293
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706298
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706304
(
R-HSA-9607240
)
R-HSA-9706308
(
R-HSA-9607240
)
R-HSA-9706312
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706315
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706319
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706323
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706328
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706330
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706340
(
R-HSA-9607240
)
R-HSA-9706340
Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1
See in Reactome
R-HSA-9706344
(
R-HSA-9607240
)
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706350
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
Reaction Name: Internalization of ubiquitinated FLT3
See in Reactome
|
MONDO:0005233 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005233 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-165158;
R-HSA-74751
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-165158;
R-HSA-74751
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-165160;
R-HSA-74751
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005335 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005335 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-165158;
R-HSA-74751
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-165158;
R-HSA-74751
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-165160;
R-HSA-74751
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005392 |
MONDO:0005392
Disease Name: scoliosis
All associated enzymes in DAR:
PTPN11
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399;
R-HSA-74751
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0007154 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007256 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007265 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007648 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007962 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399;
R-HSA-74751
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0007979 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0008093 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008093 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399;
R-HSA-74751
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008097 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008097 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0008097 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
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R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0008104 |
PTPN11 |
Q06124 |
3.1.3.48
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R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
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R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
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Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
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R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
|