DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-933541)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005097	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0005575	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0005611	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0007774	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0007959	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0008328	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0008393	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0008393	CREBBP	Q92793	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8939246 R-HSA-8939246 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of myeloid cells See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2426168 R-HSA-2426168 Reactome Name: Activation of gene expression by SREBF (SREBP) See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-6803204 R-HSA-6803204 Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-1368108 R-HSA-1368108 Reactome Name: BMAL1:CLOCK,NPAS2 activates circadian gene expression See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Circadian Clock Immune System Metabolism Developmental Biology Gene expression (Transcription) Organelle biogenesis and maintenance Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-1989746 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989746 Reaction Name: Expression of CYP7A1 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-1989756 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989756 Reaction Name: Expression of ME1 See in Reactome R-HSA-1989754 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989754 Reaction Name: Expression of APOA1 See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-1989755 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989755 Reaction Name: Expression of CYP4A11 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-1989753 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989753 Reaction Name: Expression of PEX11A See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-8938231 ( R-HSA-8939246 ) R-HSA-8938231 Reaction Name: RUNX1:CBFB binds CREBBP See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-400143 ( R-HSA-400206; R-HSA-9707564 ) R-HSA-400143 Reaction Name: Fatty acid ligands activate PPARA See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-1592238 ( R-HSA-1989781; R-HSA-2151201; R-HSA-400206 ) R-HSA-1592238 Reaction Name: Expression of ALAS1 See in Reactome R-HSA-1989751 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989751 Reaction Name: Expression of FABP1 See in Reactome R-HSA-1989777 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989777 Reaction Name: Expression of RGL1 See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-1989745 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989745 Reaction Name: Expression of ACADM See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-1989772 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989772 Reaction Name: Expression of GLIPR1 See in Reactome R-HSA-1989771 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989771 Reaction Name: Expression of TNFRSF21 See in Reactome R-HSA-1655850 ( R-HSA-1989781; R-HSA-2426168; R-HSA-400206 ) R-HSA-1655850 Reaction Name: Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) See in Reactome R-HSA-3927959 ( R-HSA-3899300 ) R-HSA-3927959 Reaction Name: SUMOylation of CREBBP with SUMO1 See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-212356 ( R-HSA-350054 ) R-HSA-212356 Reaction Name: Formation of CSL-NICD coactivator complex See in Reactome R-HSA-879724 ( R-HSA-1368108; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-879724 Reaction Name: Expression of PPARA See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-9626945 ( R-HSA-9617629 ) R-HSA-9626945 Reaction Name: CREBBP acetylates FOXO1 See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-6798004 ( R-HSA-6803204 ) R-HSA-6798004 Reaction Name: TP53 stimulates BNIP3L expression See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-1989773 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989773 Reaction Name: Expression of CPT2 See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-8938228 ( R-HSA-8939246 ) R-HSA-8938228 Reaction Name: RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter See in Reactome R-HSA-1989765 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989765 Reaction Name: Expression of ABCA1 See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-1989764 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989764 Reaction Name: Expression of CYP1A1 See in Reactome R-HSA-1989758 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989758 Reaction Name: Expression of UGT1A9 See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1989750 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989750 Reaction Name: Expression of FATP1 (SLC27A1) See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-1989775 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989775 Reaction Name: Expression of SULT2A1 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-1989747 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989747 Reaction Name: Expression of FHL2 See in Reactome R-HSA-1989776 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989776 Reaction Name: Expression of APOA2 See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-3697008 ( R-HSA-3214847 ) R-HSA-3697008 Reaction Name: CREBBP acetylates histone H2B, H3, H4 See in Reactome R-HSA-1989760 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989760 Reaction Name: Expression of HMGCS2 See in Reactome R-HSA-1989770 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989770 Reaction Name: Expression of PLIN2 See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-1989762 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989762 Reaction Name: Expression of ABCB4 See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-9626928 ( R-HSA-9617629 ) R-HSA-9626928 Reaction Name: CREBBP binds FOXO1 See in Reactome R-HSA-1989757 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989757 Reaction Name: Expression of FADS1 See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-1989778 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989778 Reaction Name: Expression of ACSL1 See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-1989767 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989767 Reaction Name: Expression of TRIB3 See in Reactome R-HSA-8938251 ( R-HSA-8939246 ) R-HSA-8938251 Reaction Name: CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP See in Reactome R-HSA-1989748 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989748 Reaction Name: Expression of GRHL1 See in Reactome R-HSA-4395227 ( R-HSA-1912408 ) R-HSA-4395227 Reaction Name: CCND1:CREBBP binds NOTCH1 promoter See in Reactome R-HSA-1989779 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989779 Reaction Name: Expression of ANKRD1 See in Reactome R-HSA-1989759 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989759 Reaction Name: Expression of G0S2 See in Reactome R-HSA-1655848 ( R-HSA-1989781; R-HSA-2426168; R-HSA-400206 ) R-HSA-1655848 Reaction Name: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-1989752 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989752 Reaction Name: Expression of TXNRD1 See in Reactome R-HSA-1989749 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989749 Reaction Name: Expression of ACOX1 See in Reactome R-HSA-1989761 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989761 Reaction Name: Expression of APOA5 See in Reactome R-HSA-1989768 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989768 Reaction Name: Expression of TIAM2 See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-1655826 ( R-HSA-1989781; R-HSA-2426168; R-HSA-400206 ) R-HSA-1655826 Reaction Name: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) See in Reactome R-HSA-1989774 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989774 Reaction Name: Expression of AGT See in Reactome R-HSA-6797993 ( R-HSA-6803204 ) R-HSA-6797993 Reaction Name: TP53 and CREBBP bind BNIP3L gene See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome
MONDO:0010150	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0012422	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0013364	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0013617	RNF135	Q8IUD6	2.3.2.27	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-918224 ( R-HSA-168928 ) R-HSA-918224 Reaction Name: DDX58 is K63 polyubiquitinated See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014367	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014575	DDX58	O95786	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8983711 R-HSA-8983711 Reactome Name: OAS antiviral response See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome	Immune System Metabolism of proteins	R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-168935 ( R-HSA-168928 ) R-HSA-168935 Reaction Name: viral dsRNA binds DDX58 See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5696564 ( R-HSA-5689880 ) R-HSA-5696564 Reaction Name: USP25 deubiquitinates DDX58 See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-8985153 ( R-HSA-8983711 ) R-HSA-8985153 Reaction Name: OASL binds DDX58 See in Reactome R-HSA-918224 ( R-HSA-168928 ) R-HSA-918224 Reaction Name: DDX58 is K63 polyubiquitinated See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936390 ( R-HSA-168928; R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-936563 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936563 Reaction Name: ISGylation of DDX58 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014641	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0015884	TRAF6	Q9Y4K3	2.3.2.27	R-HSA-937042 R-HSA-937042 Reactome Name: IRAK2 mediated activation of TAK1 complex See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-937072 R-HSA-937072 Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975163 R-HSA-975163 Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-450321 R-HSA-450321 Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-450302 R-HSA-450302 Reactome Name: activated TAK1 mediates p38 MAPK activation See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-9645460 R-HSA-9645460 Reactome Name: Alpha-protein kinase 1 signaling pathway See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975110 R-HSA-975110 Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-9014325 R-HSA-9014325 Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-166869 ( R-HSA-166058; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-166869 Reaction Name: TRAF6 binds MEKK1 See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168915 ( R-HSA-937041 ) R-HSA-168915 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-177690 ( R-HSA-9014325 ) R-HSA-177690 Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-177692 ( R-HSA-9014325 ) R-HSA-177692 Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex See in Reactome R-HSA-177694 ( R-HSA-9014325 ) R-HSA-177694 Reaction Name: Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193665 ( R-HSA-209543 ) R-HSA-193665 Reaction Name: MYD88 dissociates See in Reactome R-HSA-193669 ( R-HSA-205043 ) R-HSA-193669 Reaction Name: TRAF6 binds to p75NTR:NRIF See in Reactome R-HSA-193684 ( R-HSA-209543 ) R-HSA-193684 Reaction Name: p62 recruits an atypical PKC See in Reactome R-HSA-193694 ( R-HSA-209543 ) R-HSA-193694 Reaction Name: p62 is recruited and forms a complex with TRAF6 See in Reactome R-HSA-193695 ( R-HSA-209543 ) R-HSA-193695 Reaction Name: IRAK interacts with TRAF6 See in Reactome R-HSA-193700 ( R-HSA-193692 ) R-HSA-193700 Reaction Name: p75NTR ICD signals to NF-kB See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202453 ( R-HSA-202424 ) R-HSA-202453 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-202472 ( R-HSA-202424 ) R-HSA-202472 Reaction Name: Translocation of TRAF6 to CBM complex See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-204949 ( R-HSA-205043 ) R-HSA-204949 Reaction Name: NRIF and TRAF6 may activate JNK See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-205118 ( R-HSA-205043 ) R-HSA-205118 Reaction Name: TRAF6 polyubiquitinates NRIF See in Reactome R-HSA-209566 ( R-HSA-209543 ) R-HSA-209566 Reaction Name: TRAF6 is auto-ubiquitinated See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730864 ( R-HSA-2871837 ) R-HSA-2730864 Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-2730903 ( R-HSA-2871837 ) R-HSA-2730903 Reaction Name: Oligomerization of TRAF6 See in Reactome R-HSA-2730904 ( R-HSA-2871837 ) R-HSA-2730904 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-446862 ( R-HSA-9020702 ) R-HSA-446862 Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6 See in Reactome R-HSA-446870 ( R-HSA-9020702 ) R-HSA-446870 Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex See in Reactome R-HSA-446877 ( R-HSA-9020702 ) R-HSA-446877 Reaction Name: TRAF6 is K63 poly-ubiquitinated See in Reactome R-HSA-446894 ( R-HSA-9020702 ) R-HSA-446894 Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release See in Reactome R-HSA-450173 ( R-HSA-9020702 ) R-HSA-450173 Reaction Name: IRAK1 induces oligomerisation of TRAF6 See in Reactome R-HSA-450187 ( R-HSA-9020702 ) R-HSA-450187 Reaction Name: TAK1 is activated within the TAK1 complex See in Reactome R-HSA-450259 ( R-HSA-9014325 ) R-HSA-450259 Reaction Name: Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex See in Reactome R-HSA-450337 ( R-HSA-166058; R-HSA-450321; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450337 Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7 See in Reactome R-HSA-450346 ( R-HSA-166058; R-HSA-450302; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450346 Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6 See in Reactome R-HSA-450358 ( R-HSA-937072; R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-450358 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation See in Reactome R-HSA-507719 ( R-HSA-9020702 ) R-HSA-507719 Reaction Name: p62:MEKK3 binds to TRAF6 See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607747 ( R-HSA-5607764 ) R-HSA-5607747 Reaction Name: TRAF6 binds MALT1 oligomers See in Reactome R-HSA-5607751 ( R-HSA-5607764 ) R-HSA-5607751 Reaction Name: TRAF6 oligomerizes See in Reactome R-HSA-5607756 ( R-HSA-5607764 ) R-HSA-5607756 Reaction Name: TRAF6 oligomer autoubiquitinates See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-5690870 ( R-HSA-5689896 ) R-HSA-5690870 Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6 See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-688137 ( R-HSA-168638 ) R-HSA-688137 Reaction Name: RIP2 is K63 polyubiquitinated See in Reactome R-HSA-741386 ( R-HSA-168638 ) R-HSA-741386 Reaction Name: RIP2 induces K63-linked ubiquitination of NEMO See in Reactome R-HSA-847070 ( R-HSA-9014325 ) R-HSA-847070 Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex See in Reactome R-HSA-8869456 ( R-HSA-5689880 ) R-HSA-8869456 Reaction Name: USP4 deubiquitinate TRAF2,TRAF6 See in Reactome R-HSA-8869506 ( R-HSA-5689896 ) R-HSA-8869506 Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 See in Reactome R-HSA-8948015 ( R-HSA-9020702 ) R-HSA-8948015 Reaction Name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb See in Reactome R-HSA-8948018 ( R-HSA-9020702 ) R-HSA-8948018 Reaction Name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 See in Reactome R-HSA-9014342 ( R-HSA-168927 ) R-HSA-9014342 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936942 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936942 Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 See in Reactome R-HSA-936947 ( R-HSA-937072 ) R-HSA-936947 Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-936951 ( R-HSA-937072 ) R-HSA-936951 Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex See in Reactome R-HSA-936952 ( R-HSA-937072 ) R-HSA-936952 Reaction Name: Auto ubiquitination of TRAF6 bound to the activated TLR4 complex See in Reactome R-HSA-936960 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936960 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex See in Reactome R-HSA-936963 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936963 Reaction Name: IRAK2 induces TRAF6 oligomerization See in Reactome R-HSA-936985 ( R-HSA-937072 ) R-HSA-936985 Reaction Name: Activated TLR4:TICAM1 recruits TRAF6 See in Reactome R-HSA-936986 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936986 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains See in Reactome R-HSA-936991 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936991 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 See in Reactome R-HSA-937032 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-937034 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937034 Reaction Name: IRAK1 phosphorylates Pellino See in Reactome R-HSA-937044 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937044 Reaction Name: Pellino binds hp-IRAK1:TRAF6 See in Reactome R-HSA-937050 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937050 Reaction Name: Pellino ubiquitinates hp-IRAK1 See in Reactome R-HSA-937075 ( R-HSA-937072 ) R-HSA-937075 Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex See in Reactome R-HSA-9628444 ( R-HSA-9014325 ) R-HSA-9628444 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation See in Reactome R-HSA-9645394 ( R-HSA-9645460 ) R-HSA-9645394 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation See in Reactome R-HSA-9645406 ( R-HSA-9645460 ) R-HSA-9645406 Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) See in Reactome R-HSA-9645414 ( R-HSA-9645460 ) R-HSA-9645414 Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer See in Reactome R-HSA-9645442 ( R-HSA-9645460 ) R-HSA-9645442 Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex See in Reactome R-HSA-9645501 ( R-HSA-9645460 ) R-HSA-9645501 Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex See in Reactome R-HSA-9645520 ( R-HSA-9645460 ) R-HSA-9645520 Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-975097 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975097 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975100 ( R-HSA-975138; R-HSA-975155 ) R-HSA-975100 Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex See in Reactome R-HSA-975103 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975103 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation See in Reactome R-HSA-975106 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975106 Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975111 ( R-HSA-975155 ) R-HSA-975111 Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975118 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975118 Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex See in Reactome R-HSA-975119 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome R-HSA-975122 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975122 Reaction Name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> See in Reactome R-HSA-975139 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975139 Reaction Name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation See in Reactome R-HSA-975142 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975142 Reaction Name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation See in Reactome R-HSA-975147 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975147 Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane See in Reactome R-HSA-975185 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975185 Reaction Name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments See in Reactome R-HSA-975188 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975188 Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975857 ( R-HSA-975871 ) R-HSA-975857 Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2 See in Reactome R-HSA-975879 ( R-HSA-975871 ) R-HSA-975879 Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex See in Reactome
MONDO:0019086	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0020763	CREBBP	Q92793	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8939246 R-HSA-8939246 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of myeloid cells See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2426168 R-HSA-2426168 Reactome Name: Activation of gene expression by SREBF (SREBP) See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-6803204 R-HSA-6803204 Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-1368108 R-HSA-1368108 Reactome Name: BMAL1:CLOCK,NPAS2 activates circadian gene expression See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Circadian Clock Immune System Metabolism Developmental Biology Gene expression (Transcription) Organelle biogenesis and maintenance Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-1989746 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989746 Reaction Name: Expression of CYP7A1 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-1989756 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989756 Reaction Name: Expression of ME1 See in Reactome R-HSA-1989754 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989754 Reaction Name: Expression of APOA1 See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-1989755 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989755 Reaction Name: Expression of CYP4A11 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-1989753 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989753 Reaction Name: Expression of PEX11A See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-8938231 ( R-HSA-8939246 ) R-HSA-8938231 Reaction Name: RUNX1:CBFB binds CREBBP See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-400143 ( R-HSA-400206; R-HSA-9707564 ) R-HSA-400143 Reaction Name: Fatty acid ligands activate PPARA See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-1592238 ( R-HSA-1989781; R-HSA-2151201; R-HSA-400206 ) R-HSA-1592238 Reaction Name: Expression of ALAS1 See in Reactome R-HSA-1989751 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989751 Reaction Name: Expression of FABP1 See in Reactome R-HSA-1989777 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989777 Reaction Name: Expression of RGL1 See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-1989745 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989745 Reaction Name: Expression of ACADM See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-1989772 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989772 Reaction Name: Expression of GLIPR1 See in Reactome R-HSA-1989771 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989771 Reaction Name: Expression of TNFRSF21 See in Reactome R-HSA-1655850 ( R-HSA-1989781; R-HSA-2426168; R-HSA-400206 ) R-HSA-1655850 Reaction Name: Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) See in Reactome R-HSA-3927959 ( R-HSA-3899300 ) R-HSA-3927959 Reaction Name: SUMOylation of CREBBP with SUMO1 See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-212356 ( R-HSA-350054 ) R-HSA-212356 Reaction Name: Formation of CSL-NICD coactivator complex See in Reactome R-HSA-879724 ( R-HSA-1368108; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-879724 Reaction Name: Expression of PPARA See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-9626945 ( R-HSA-9617629 ) R-HSA-9626945 Reaction Name: CREBBP acetylates FOXO1 See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-6798004 ( R-HSA-6803204 ) R-HSA-6798004 Reaction Name: TP53 stimulates BNIP3L expression See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-1989773 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989773 Reaction Name: Expression of CPT2 See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-8938228 ( R-HSA-8939246 ) R-HSA-8938228 Reaction Name: RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter See in Reactome R-HSA-1989765 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989765 Reaction Name: Expression of ABCA1 See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-1989764 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989764 Reaction Name: Expression of CYP1A1 See in Reactome R-HSA-1989758 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989758 Reaction Name: Expression of UGT1A9 See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1989750 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989750 Reaction Name: Expression of FATP1 (SLC27A1) See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-1989775 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989775 Reaction Name: Expression of SULT2A1 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-1989747 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989747 Reaction Name: Expression of FHL2 See in Reactome R-HSA-1989776 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989776 Reaction Name: Expression of APOA2 See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-3697008 ( R-HSA-3214847 ) R-HSA-3697008 Reaction Name: CREBBP acetylates histone H2B, H3, H4 See in Reactome R-HSA-1989760 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989760 Reaction Name: Expression of HMGCS2 See in Reactome R-HSA-1989770 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989770 Reaction Name: Expression of PLIN2 See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-1989762 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989762 Reaction Name: Expression of ABCB4 See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-9626928 ( R-HSA-9617629 ) R-HSA-9626928 Reaction Name: CREBBP binds FOXO1 See in Reactome R-HSA-1989757 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989757 Reaction Name: Expression of FADS1 See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-1989778 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989778 Reaction Name: Expression of ACSL1 See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-1989767 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989767 Reaction Name: Expression of TRIB3 See in Reactome R-HSA-8938251 ( R-HSA-8939246 ) R-HSA-8938251 Reaction Name: CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP See in Reactome R-HSA-1989748 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989748 Reaction Name: Expression of GRHL1 See in Reactome R-HSA-4395227 ( R-HSA-1912408 ) R-HSA-4395227 Reaction Name: CCND1:CREBBP binds NOTCH1 promoter See in Reactome R-HSA-1989779 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989779 Reaction Name: Expression of ANKRD1 See in Reactome R-HSA-1989759 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989759 Reaction Name: Expression of G0S2 See in Reactome R-HSA-1655848 ( R-HSA-1989781; R-HSA-2426168; R-HSA-400206 ) R-HSA-1655848 Reaction Name: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-1989752 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989752 Reaction Name: Expression of TXNRD1 See in Reactome R-HSA-1989749 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989749 Reaction Name: Expression of ACOX1 See in Reactome R-HSA-1989761 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989761 Reaction Name: Expression of APOA5 See in Reactome R-HSA-1989768 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989768 Reaction Name: Expression of TIAM2 See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-1655826 ( R-HSA-1989781; R-HSA-2426168; R-HSA-400206 ) R-HSA-1655826 Reaction Name: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) See in Reactome R-HSA-1989774 ( R-HSA-1989781; R-HSA-400206 ) R-HSA-1989774 Reaction Name: Expression of AGT See in Reactome R-HSA-6797993 ( R-HSA-6803204 ) R-HSA-6797993 Reaction Name: TP53 and CREBBP bind BNIP3L gene See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome
MONDO:0020769	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0021230	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400206; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340; R-HSA-400206 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-168928; R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-168928; R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400206; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0024535	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0054754	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome

Number of enzymes:	7
Number of disease:	21
Number of reactomes:	96
Number of reactions:	386

Search summary (Reactome ID: R-HSA-933541)

Search results (Reactome ID: R-HSA-933541)

MONDO:0005097

R-HSA-9617629

R-HSA-210744

R-HSA-5689901

R-HSA-6804760

R-HSA-8939243

R-HSA-381340

R-HSA-9616222

R-HSA-9013695

R-HSA-6782135

R-HSA-6782210

R-HSA-8941856

R-HSA-8941858

R-HSA-6804114

R-HSA-1989781

R-HSA-9018519

R-HSA-918233

R-HSA-6781827

R-HSA-156711

R-HSA-5250924

R-HSA-6781823

R-HSA-9013508

R-HSA-3214847

R-HSA-3371568

R-HSA-8866907

R-HSA-9614657

R-HSA-9701898

R-HSA-933541

R-HSA-1234158

R-HSA-1368082

R-HSA-5617472

R-HSA-3899300

R-HSA-9029569

R-HSA-8936459

R-HSA-2122947

R-HSA-2197563

R-HSA-400253

R-HSA-9707616

R-HSA-3134973

R-HSA-201722

R-HSA-1912408

R-HSA-8951936

R-HSA-5621575

R-HSA-9031628

R-HSA-6811555

R-HSA-6804758

R-HSA-3700989

R-HSA-9012852

R-HSA-5633007

R-HSA-168256

R-HSA-9013694

R-HSA-168928

R-HSA-1640170

R-HSA-597592

R-HSA-6791312

R-HSA-1266738

R-HSA-73857

R-HSA-1430728

R-HSA-8864260

R-HSA-166520

R-HSA-212436

R-HSA-74160

R-HSA-400206

R-HSA-2262752

R-HSA-73894

R-HSA-69278

R-HSA-198725

R-HSA-2990846

R-HSA-556833

R-HSA-9024446

R-HSA-8878159

R-HSA-5621481

R-HSA-8953897

R-HSA-212165

R-HSA-5696398

R-HSA-168249

R-HSA-453274

R-HSA-392499