DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-917977)

Number of enzymes:	2
Number of disease:	5
Number of reactomes:	11
Number of reactions:	20

Search results (Reactome ID: R-HSA-917977)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009054	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0014094	STEAP3	Q658P3	1.16.1.-	R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-9035034 R-HSA-9035034 Reactome Name: RHOF GTPase cycle See in Reactome R-HSA-6803204 R-HSA-6803204 Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Transport of small molecules Signal Transduction	R-HSA-6801184 ( R-HSA-6803204 ) R-HSA-6801184 Reaction Name: TP53 stimulates STEAP3 expression See in Reactome R-HSA-6801195 ( R-HSA-6803204 ) R-HSA-6801195 Reaction Name: STEAP3 binds BNIP3L See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-917811 ( R-HSA-917977 ) R-HSA-917811 Reaction Name: STEAP3-like proteins reduce Fe3+ to Fe2+ See in Reactome R-HSA-9693125 ( R-HSA-9035034 ) R-HSA-9693125 Reaction Name: RHOF binds effectors at the plasma membrane See in Reactome R-HSA-9693198 ( R-HSA-9013405 ) R-HSA-9693198 Reaction Name: RHOD binds effectors at the plasma membrane See in Reactome
MONDO:0018614	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0020632	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0027451	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome