DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-917937)

Number of enzymes:	4
Number of disease:	4
Number of reactomes:	14
Number of reactions:	25

Search results (Reactome ID: R-HSA-917937)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011426	CP	P00450	1.16.3.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-425410 R-HSA-425410 Reactome Name: Metal ion SLC transporters See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-425407 R-HSA-425407 Reactome Name: SLC-mediated transmembrane transport See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-425366 R-HSA-425366 Reactome Name: Transport of bile salts and organic acids, metal ions and amine compounds See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Metabolism of proteins Transport of small molecules	R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-904830 ( R-HSA-425410; R-HSA-917937 ) R-HSA-904830 Reaction Name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region See in Reactome R-HSA-917891 ( R-HSA-917937 ) R-HSA-917891 Reaction Name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ See in Reactome
MONDO:0011631	SLC40A1	Q9NP59	-	R-HSA-425410 R-HSA-425410 Reactome Name: Metal ion SLC transporters See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome	R-HSA-425407 R-HSA-425407 Reactome Name: SLC-mediated transmembrane transport See in Reactome R-HSA-425366 R-HSA-425366 Reactome Name: Transport of bile salts and organic acids, metal ions and amine compounds See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-442368 ( R-HSA-425410; R-HSA-917937 ) R-HSA-442368 Reaction Name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region See in Reactome R-HSA-904830 ( R-HSA-425410; R-HSA-917937 ) R-HSA-904830 Reaction Name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region See in Reactome R-HSA-917891 ( R-HSA-917937 ) R-HSA-917891 Reaction Name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ See in Reactome R-HSA-917933 ( R-HSA-917937 ) R-HSA-917933 Reaction Name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ See in Reactome
MONDO:0013536	HMOX1	P09601	1.14.14.18	R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-9707587 R-HSA-9707587 Reactome Name: Regulation of HMOX1 expression and activity See in Reactome R-HSA-844456 R-HSA-844456 Reactome Name: The NLRP3 inflammasome See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9609523 R-HSA-9609523 Reactome Name: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-622312 R-HSA-622312 Reactome Name: Inflammasomes See in Reactome	Cellular responses to stimuli Protein localization Immune System Transport of small molecules Metabolism	R-HSA-1250272 ( R-HSA-844456; R-HSA-9707564 ) R-HSA-1250272 Reaction Name: TXNIP binds NLRP3 See in Reactome R-HSA-189398 ( R-HSA-189483; R-HSA-917937; R-HSA-9707564 ) R-HSA-189398 Reaction Name: HMOX1 dimer, HMOX2 cleave heme See in Reactome R-HSA-6797268 ( R-HSA-6785807 ) R-HSA-6797268 Reaction Name: Expression of HMOX1 See in Reactome R-HSA-9609860 ( R-HSA-9609523 ) R-HSA-9609860 Reaction Name: Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP See in Reactome R-HSA-9609899 ( R-HSA-9609523 ) R-HSA-9609899 Reaction Name: Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane See in Reactome R-HSA-9609917 ( R-HSA-9609523 ) R-HSA-9609917 Reaction Name: Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane See in Reactome R-HSA-9609921 ( R-HSA-9609523 ) R-HSA-9609921 Reaction Name: SGTA binds Tail-anchored protein See in Reactome R-HSA-9610442 ( R-HSA-9609523 ) R-HSA-9610442 Reaction Name: Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP See in Reactome R-HSA-9707645 ( R-HSA-9707564; R-HSA-9707587; R-HSA-9707616 ) R-HSA-9707645 Reaction Name: HMOX1 gene produces HMOX1 dimer See in Reactome R-HSA-9708457 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708457 Reaction Name: HM13 cleaves HMOX1 dimer See in Reactome R-HSA-9708536 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708536 Reaction Name: HMOX1 translocates from the cytosol to the nucleoplasm See in Reactome R-HSA-9708558 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708558 Reaction Name: HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane See in Reactome R-HSA-9709918 ( R-HSA-9707564 ) R-HSA-9709918 Reaction Name: PTK6 phosphorylates STAT3 See in Reactome R-HSA-9759176 () R-HSA-9759176 Reaction Name: NFE2L2-dependent HMOX1 gene expression See in Reactome
MONDO:0014225	FTH1	P02794	1.16.3.1	R-HSA-3000480 R-HSA-3000480 Reactome Name: Scavenging by Class A Receptors See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Transport of small molecules Vesicle-mediated transport	R-HSA-1562626 ( R-HSA-917937 ) R-HSA-1562626 Reaction Name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) See in Reactome R-HSA-2187266 ( R-HSA-3000480 ) R-HSA-2187266 Reaction Name: SCARA5 binds ligands See in Reactome R-HSA-2299677 ( R-HSA-3000480 ) R-HSA-2299677 Reaction Name: SCARA5:ligand is endocytosed See in Reactome R-HSA-434362 ( R-HSA-432722 ) R-HSA-434362 Reaction Name: Recruitment Of Cytoplasmic Proteins To Vesicles See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome