DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-909733)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002049	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0005062	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0005392	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0007483	ADAR	P55265	3.5.4.37	R-HSA-77042 R-HSA-77042 Reactome Name: Formation of editosomes by ADAR proteins See in Reactome R-HSA-75102 R-HSA-75102 Reactome Name: C6 deamination of adenosine See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-75064 R-HSA-75064 Reactome Name: mRNA Editing: A to I Conversion See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-75072 R-HSA-75072 Reactome Name: mRNA Editing See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome	Metabolism of RNA Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-111237 ( R-HSA-77042 ) R-HSA-111237 Reaction Name: Formation of ADAR1 homodimer See in Reactome R-HSA-75090 ( R-HSA-77042 ) R-HSA-75090 Reaction Name: Binding of ADAR1 homodimer to dsRNA duplex See in Reactome R-HSA-77614 ( R-HSA-75102 ) R-HSA-77614 Reaction Name: Deamination at C6 position of adenosine in Editosome (ADAR1) See in Reactome
MONDO:0007979	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0008104	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0009539	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0009891	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0010080	ADAR	P55265	3.5.4.37	R-HSA-77042 R-HSA-77042 Reactome Name: Formation of editosomes by ADAR proteins See in Reactome R-HSA-75102 R-HSA-75102 Reactome Name: C6 deamination of adenosine See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-75064 R-HSA-75064 Reactome Name: mRNA Editing: A to I Conversion See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-75072 R-HSA-75072 Reactome Name: mRNA Editing See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome	Metabolism of RNA Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-111237 ( R-HSA-77042 ) R-HSA-111237 Reaction Name: Formation of ADAR1 homodimer See in Reactome R-HSA-75090 ( R-HSA-77042 ) R-HSA-75090 Reaction Name: Binding of ADAR1 homodimer to dsRNA duplex See in Reactome R-HSA-77614 ( R-HSA-75102 ) R-HSA-77614 Reaction Name: Deamination at C6 position of adenosine in Editosome (ADAR1) See in Reactome
MONDO:0011098	RNASEL	Q05823	3.1.26.-	R-HSA-8983711 R-HSA-8983711 Reactome Name: OAS antiviral response See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome	Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-5223305 ( R-HSA-909733 ) R-HSA-5223305 Reaction Name: ABCE1 binds RNASEL, inhibiting it See in Reactome R-HSA-8985123 ( R-HSA-8983711 ) R-HSA-8985123 Reaction Name: RNASEL binds 2'-5' oligoadenylate See in Reactome R-HSA-8985201 ( R-HSA-8983711 ) R-HSA-8985201 Reaction Name: ABCE1 binds RNASEL See in Reactome R-HSA-9009936 ( R-HSA-8983711 ) R-HSA-9009936 Reaction Name: RNASEL cleaves cellular ssRNA See in Reactome R-HSA-9009941 ( R-HSA-8983711 ) R-HSA-9009941 Reaction Name: RNASEL cleaves viral ssRNA See in Reactome
MONDO:0011908	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0012371	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0012682	TYK2	P29597	2.7.10.2	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6785762 ( R-HSA-6785807 ) R-HSA-6785762 Reaction Name: IL13RA1 binds TYK2 See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-6786118 ( R-HSA-6785807 ) R-HSA-6786118 Reaction Name: IL13 binds IL13RA:TYK2 See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-8950057 ( R-HSA-9020591 ) R-HSA-8950057 Reaction Name: IL12RB1 binds TYK2 See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-8987223 ( R-HSA-8854691 ) R-HSA-8987223 Reaction Name: IL10RB binds TYK2 See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9678737 ( R-HSA-909733 ) R-HSA-9678737 Reaction Name: IFNAR1:TYK2 binds TYK2 inhibitors See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome
MONDO:0013059	SAMHD1	Q9Y3Z3	3.1.5.-	R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-8866601 ( R-HSA-8956319 ) R-HSA-8866601 Reaction Name: SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate See in Reactome
MONDO:0013308	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0013739	SAMHD1	Q9Y3Z3	3.1.5.-	R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-8866601 ( R-HSA-8956319 ) R-HSA-8866601 Reaction Name: SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate See in Reactome
MONDO:0014007	ADAR	P55265	3.5.4.37	R-HSA-77042 R-HSA-77042 Reactome Name: Formation of editosomes by ADAR proteins See in Reactome R-HSA-75102 R-HSA-75102 Reactome Name: C6 deamination of adenosine See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-75064 R-HSA-75064 Reactome Name: mRNA Editing: A to I Conversion See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-75072 R-HSA-75072 Reactome Name: mRNA Editing See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome	Metabolism of RNA Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-111237 ( R-HSA-77042 ) R-HSA-111237 Reaction Name: Formation of ADAR1 homodimer See in Reactome R-HSA-75090 ( R-HSA-77042 ) R-HSA-75090 Reaction Name: Binding of ADAR1 homodimer to dsRNA duplex See in Reactome R-HSA-77614 ( R-HSA-75102 ) R-HSA-77614 Reaction Name: Deamination at C6 position of adenosine in Editosome (ADAR1) See in Reactome
MONDO:0016225	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0020526	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0033558	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0054698	PSMB8	P28062	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0100082	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome

Number of enzymes:	7
Number of disease:	22
Number of reactomes:	120
Number of reactions:	386

Search summary (Reactome ID: R-HSA-909733)

Search results (Reactome ID: R-HSA-909733)

MONDO:0002049

R-HSA-389948

R-HSA-418886

R-HSA-9674555

R-HSA-114604

R-HSA-2586552

R-HSA-5654732

R-HSA-912694

R-HSA-186763

R-HSA-180292

R-HSA-8853659

R-HSA-9008059

R-HSA-1257604

R-HSA-5654710

R-HSA-5654720

R-HSA-5654689

R-HSA-9607240

R-HSA-389513

R-HSA-5654726

R-HSA-5654727

R-HSA-5654700

R-HSA-5654706

R-HSA-432142

R-HSA-391160

R-HSA-1295596

R-HSA-8934593

R-HSA-909733

R-HSA-1433557

R-HSA-512988

R-HSA-5654695

R-HSA-388841

R-HSA-5654693

R-HSA-1059683

R-HSA-9645135

R-HSA-8865999

R-HSA-5654733

R-HSA-1170546

R-HSA-112411

R-HSA-109704

R-HSA-877312

R-HSA-5654712

R-HSA-210993

R-HSA-6811558

R-HSA-210990

R-HSA-9028731

R-HSA-110056

R-HSA-8854691

R-HSA-936964

R-HSA-937061

R-HSA-2404192

R-HSA-449147

R-HSA-168256

R-HSA-202733

R-HSA-1500931

R-HSA-9006925

R-HSA-2428924

R-HSA-5654741

R-HSA-2428928

R-HSA-74752

R-HSA-1280218

R-HSA-1266738

R-HSA-73857

R-HSA-168898

R-HSA-5654687

R-HSA-5683057

R-HSA-166520

R-HSA-212436

R-HSA-74160

R-HSA-76002

R-HSA-8878171

R-HSA-112399

R-HSA-199418

R-HSA-877300

R-HSA-418346

R-HSA-166166

R-HSA-6783589

R-HSA-5654708

R-HSA-74751