MONDO:0001187 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0001187 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005012 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005029 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0005233 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005335 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0007154 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007256 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007265 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007572 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0007648 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0008093 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008097 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008097 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0008097 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0008566 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008566 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0009026 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0009578 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0009692 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0009693 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0009891 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0010854 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0010947 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0011908 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0011908 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0012371 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0013186 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0013767 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0013767 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0013794 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0014112 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0015278 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0015447 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0016419 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0016692 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0016982 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0017317 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0018874 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0018874 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0019086 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0019311 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0019438 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0044792 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0044792 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
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R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
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R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
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R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
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R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
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