DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9020591)

Number of enzymes:	4
Number of disease:	13
Number of reactomes:	48
Number of reactions:	358

Search results (Reactome ID: R-HSA-9020591)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005029	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0007204	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0007572	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0008146	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0009539	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0009692	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0009891	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0009891	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0010947	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0012682	TYK2	P29597	2.7.10.2	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6785762 ( R-HSA-6785807 ) R-HSA-6785762 Reaction Name: IL13RA1 binds TYK2 See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-6786118 ( R-HSA-6785807 ) R-HSA-6786118 Reaction Name: IL13 binds IL13RA:TYK2 See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-8950057 ( R-HSA-9020591 ) R-HSA-8950057 Reaction Name: IL12RB1 binds TYK2 See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-8987223 ( R-HSA-8854691 ) R-HSA-8987223 Reaction Name: IL10RB binds TYK2 See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9678737 ( R-HSA-909733 ) R-HSA-9678737 Reaction Name: IFNAR1:TYK2 binds TYK2 inhibitors See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome
MONDO:0013794	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0018874	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0020526	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0033558	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome