DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9020558)

Number of enzymes:	4
Number of disease:	10
Number of reactomes:	56
Number of reactions:	335

Search results (Reactome ID: R-HSA-9020558)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005292	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0005578	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0006547	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0009539	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0009891	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0010938	JAK3	P52333	2.7.10.2	R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-451895 ( R-HSA-1266695; R-HSA-6785807; R-HSA-8985947; R-HSA-9020558 ) R-HSA-451895 Reaction Name: IL2RG binds JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-453104 ( R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-453111 ( R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-508247 ( R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-508451 ( R-HSA-9020558 ) R-HSA-508451 Reaction Name: PTK2B is phosphorylated See in Reactome R-HSA-508513 ( R-HSA-9020558 ) R-HSA-508513 Reaction Name: PTK2B binds JAK3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-912527 ( R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-913424 ( R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-9679028 ( R-HSA-1266695; R-HSA-6785807; R-HSA-8985947; R-HSA-9020558 ) R-HSA-9679028 Reaction Name: JAK3 binds JAK3 inhibitors See in Reactome R-HSA-9701485 ( R-HSA-201556 ) R-HSA-9701485 Reaction Name: Active ALK binds JAK3 See in Reactome R-HSA-9701488 ( R-HSA-201556 ) R-HSA-9701488 Reaction Name: Active ALK phosphorylates JAK3 See in Reactome R-HSA-9701507 ( R-HSA-201556 ) R-HSA-9701507 Reaction Name: PTPN6 dephosphorylates JAK3 See in Reactome
MONDO:0014334	LCK	P06239	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-202427 R-HSA-202427 Reactome Name: Phosphorylation of CD3 and TCR zeta chains See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome	Hemostasis Immune System Signal Transduction	R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-202165 ( R-HSA-202427 ) R-HSA-202165 Reaction Name: Phosphorylation of ITAM motifs in CD3 complexes See in Reactome R-HSA-202168 ( R-HSA-202430 ) R-HSA-202168 Reaction Name: Phosphorylation of ZAP-70 by Lck See in Reactome R-HSA-202174 ( R-HSA-202430 ) R-HSA-202174 Reaction Name: Activation of ZAP-70 See in Reactome R-HSA-202214 ( R-HSA-202427 ) R-HSA-202214 Reaction Name: Dephosphorylation of Lck-pY505 by CD45 See in Reactome R-HSA-202216 ( R-HSA-202433 ) R-HSA-202216 Reaction Name: Phosphorylation of SLP-76 See in Reactome R-HSA-202233 ( R-HSA-202427 ) R-HSA-202233 Reaction Name: Inactivation of Lck by Csk See in Reactome R-HSA-202245 ( R-HSA-202433 ) R-HSA-202245 Reaction Name: Phosphorylation of TBSMs in LAT See in Reactome R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202291 ( R-HSA-202427 ) R-HSA-202291 Reaction Name: Activation of Lck See in Reactome R-HSA-202307 ( R-HSA-202424 ) R-HSA-202307 Reaction Name: Change of PKC theta conformation See in Reactome R-HSA-202344 ( R-HSA-202430 ) R-HSA-202344 Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-210291 ( R-HSA-210990 ) R-HSA-210291 Reaction Name: Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395439 ( R-HSA-2424491 ) R-HSA-2395439 Reaction Name: Phosphorylation of DAP12 See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-388814 ( R-HSA-389356; R-HSA-389359 ) R-HSA-388814 Reaction Name: Grb2 binds CD28 See in Reactome R-HSA-388829 ( R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-388831 ( R-HSA-389356 ) R-HSA-388831 Reaction Name: Phosphorylation of CD28 See in Reactome R-HSA-388832 ( R-HSA-389356; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-388833 ( R-HSA-389513 ) R-HSA-388833 Reaction Name: Phosphorylation of CTLA-4 See in Reactome R-HSA-389158 ( R-HSA-389356; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-389348 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389350 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389350 Reaction Name: Activation of Cdc42 by pVav1 See in Reactome R-HSA-389352 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389352 Reaction Name: Translocation of Vav1 to CD28 See in Reactome R-HSA-389354 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389354 Reaction Name: Activation of Vav1 See in Reactome R-HSA-389381 ( R-HSA-389356 ) R-HSA-389381 Reaction Name: Gads binds CD28 See in Reactome R-HSA-389758 ( R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389762 ( R-HSA-389948 ) R-HSA-389762 Reaction Name: Phosphorylation of PD-1 See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8852200 ( R-HSA-202427 ) R-HSA-8852200 Reaction Name: Inactivation of LCK by PTPN22 See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9706312 ( R-HSA-9706374 ) R-HSA-9706312 Reaction Name: Active FLT3 binds to LCK See in Reactome
MONDO:0020526	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0021094	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0033558	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome