DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9017802)

Number of enzymes:	2
Number of disease:	8
Number of reactomes:	11
Number of reactions:	14

Search results (Reactome ID: R-HSA-9017802)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007088	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0008243	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0010857	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011743	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011743	PSEN2	P49810	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011913	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013371	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013373	PSEN2	P49810	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013398	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome