DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-9013507)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002911	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005097	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005233	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005335	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005580	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0007088	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0008021	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008243	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0008315	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0010150	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0010857	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011743	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011743	PSEN2	P49810	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011913	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013371	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013373	PSEN2	P49810	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013398	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0014042	MIB1	Q86YT6	2.3.2.27	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome	Signal Transduction	R-HSA-1980074 ( R-HSA-2122948 ) R-HSA-1980074 Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 See in Reactome R-HSA-2172172 ( R-HSA-2979096 ) R-HSA-2172172 Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 See in Reactome R-HSA-9013069 ( R-HSA-9013507 ) R-HSA-9013069 Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 See in Reactome
MONDO:0014234	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014265	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014481	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0018177	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome

Number of enzymes:	5
Number of disease:	21
Number of reactomes:	41
Number of reactions:	132

Search summary (Reactome ID: R-HSA-9013507)

Search results (Reactome ID: R-HSA-9013507)

MONDO:0002911

R-HSA-445144

R-HSA-1251932

R-HSA-9634638

R-HSA-1963640

R-HSA-1963642

R-HSA-180292

R-HSA-1236394

R-HSA-8863795

R-HSA-5673001

R-HSA-9013507

R-HSA-1257604

R-HSA-177929

R-HSA-8857538

R-HSA-8856828

R-HSA-8856825

R-HSA-1227986

R-HSA-9009391

R-HSA-180336

R-HSA-8847993

R-HSA-212718

R-HSA-182971

R-HSA-179812

R-HSA-1250196

R-HSA-8866910

R-HSA-6811558

R-HSA-2179392

R-HSA-6785631

R-HSA-9012852

R-HSA-157118

R-HSA-9006927

R-HSA-9006925

R-HSA-8848021

R-HSA-5684996

R-HSA-1266738

R-HSA-73857

R-HSA-8864260

R-HSA-212436

R-HSA-74160

R-HSA-881907

R-HSA-9675108

R-HSA-199418

R-HSA-5653656

R-HSA-373760

R-HSA-388396

R-HSA-199991

R-HSA-9006931

R-HSA-8939211

R-HSA-5683057

R-HSA-372790

R-HSA-416476

R-HSA-9006934

R-HSA-422475

R-HSA-162582

R-HSA-1250195

R-HSA-1250463

R-HSA-1250486

R-HSA-1250488

R-HSA-1250498

R-HSA-1251922

R-HSA-1251944

R-HSA-1306957

R-HSA-1306963

R-HSA-1306965

R-HSA-177922

R-HSA-177923

R-HSA-177924

R-HSA-177925

R-HSA-177926

R-HSA-177927

R-HSA-177930

R-HSA-177933

R-HSA-177934

R-HSA-177935

R-HSA-177936

R-HSA-177937

R-HSA-177938

R-HSA-177939