DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-9013408)

Number of enzymes:	8
Number of disease:	18
Number of reactomes:	55
Number of reactions:	136

Search results (Reactome ID: R-HSA-9013408)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007288	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0008214	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0008913	PLD1	Q13393	3.1.4.4	R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1483166 R-HSA-1483166 Reactome Name: Synthesis of PA See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1483148 R-HSA-1483148 Reactome Name: Synthesis of PG See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Signal Transduction	R-HSA-1483142 ( R-HSA-1483148 ) R-HSA-1483142 Reaction Name: PC is transphosphatidylated to PG by PLD1-4/6 See in Reactome R-HSA-1483182 ( R-HSA-1483166 ) R-HSA-1483182 Reaction Name: PC is hydrolyzed to PA and choline by PLD1/2 See in Reactome R-HSA-2029471 ( R-HSA-2029485 ) R-HSA-2029471 Reaction Name: Hydrolysis of PC to PA by PLD See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome
MONDO:0008974	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0010949	RAB7A	P51149	3.6.5.2	R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-8873719 R-HSA-8873719 Reactome Name: RAB geranylgeranylation See in Reactome R-HSA-8854214 R-HSA-8854214 Reactome Name: TBC/RABGAPs See in Reactome R-HSA-9035034 R-HSA-9035034 Reactome Name: RHOF GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism of proteins Signal Transduction Vesicle-mediated transport	R-HSA-2213248 ( R-HSA-2132295 ) R-HSA-2213248 Reaction Name: Transport of antigen loaded MHC II molecules to surface See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-8854255 ( R-HSA-8854214 ) R-HSA-8854255 Reaction Name: TBC1D2A accelerates GTP hydrolysis by RAB7 See in Reactome R-HSA-8854329 ( R-HSA-8854214 ) R-HSA-8854329 Reaction Name: TBC1D15 accelerates GTP hydrolysis by RAB7 See in Reactome R-HSA-8870466 ( R-HSA-8873719 ) R-HSA-8870466 Reaction Name: RGGT:CHM binds RABs See in Reactome R-HSA-8870469 ( R-HSA-8873719 ) R-HSA-8870469 Reaction Name: RGGT geranylgeranylates RAB proteins See in Reactome R-HSA-8877451 ( R-HSA-8876198 ) R-HSA-8877451 Reaction Name: MON1:CCZ1 exchanges GTP for GDP on RAB7 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9693125 ( R-HSA-9035034 ) R-HSA-9693125 Reaction Name: RHOF binds effectors at the plasma membrane See in Reactome R-HSA-9693198 ( R-HSA-9013405 ) R-HSA-9693198 Reaction Name: RHOD binds effectors at the plasma membrane See in Reactome
MONDO:0013276	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0014757	CDC42	P60953	3.6.5.2	R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-8964616 R-HSA-8964616 Reactome Name: G beta:gamma signalling through CDC42 See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-183002 ( R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183084 ( R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183094 ( R-HSA-182971 ) R-HSA-183094 Reaction Name: CDC42:GTP binds CBL:Beta-Pix See in Reactome R-HSA-2029445 ( R-HSA-2029482 ) R-HSA-2029445 Reaction Name: An unknown GEF exchanges GTP for GDP on CDC42:GDP See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2197691 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197691 Reaction Name: WIP binds WASP,N-WASP, activating them See in Reactome R-HSA-2197698 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197698 Reaction Name: Src phosphorylate WASP,N-WASP See in Reactome R-HSA-376117 ( R-HSA-525793 ) R-HSA-376117 Reaction Name: JLP interacts with CDO complex See in Reactome R-HSA-376119 ( R-HSA-525793 ) R-HSA-376119 Reaction Name: Interaction of Bnip-2 with Cdc42 See in Reactome R-HSA-389350 ( R-HSA-389359 ) R-HSA-389350 Reaction Name: Activation of Cdc42 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928595 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928595 Reaction Name: N-WASP binds ARP2/3 and G-actin See in Reactome R-HSA-3928601 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928601 Reaction Name: CDC42 and PIP2 bind WASL, activating it See in Reactome R-HSA-3928632 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928632 Reaction Name: ITSN1 exchanges GTP for GDP on CDC42, activating it See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-428533 ( R-HSA-428543 ) R-HSA-428533 Reaction Name: Inactivation of CDC42 See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442586 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442586 Reaction Name: Activation of WASP and N-WASP by CDC42 See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5218804 ( R-HSA-4420097 ) R-HSA-5218804 Reaction Name: p38 MAPK activation by VEGFR See in Reactome R-HSA-5218812 ( R-HSA-4420097 ) R-HSA-5218812 Reaction Name: FYN phosphorylates PAK2 See in Reactome R-HSA-5218814 ( R-HSA-4420097 ) R-HSA-5218814 Reaction Name: PAK2 autophorylates See in Reactome R-HSA-5218829 ( R-HSA-4420097 ) R-HSA-5218829 Reaction Name: VEGF induces CDC42 activation by unknown mechanism See in Reactome R-HSA-5218832 ( R-HSA-4420097 ) R-HSA-5218832 Reaction Name: CDC42:GTP binds PAK2 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5665686 ( R-HSA-5663220 ) R-HSA-5665686 Reaction Name: FMNL1 binds CDC42:GTP See in Reactome R-HSA-5665727 ( R-HSA-5663220 ) R-HSA-5665727 Reaction Name: FMNL2 binds CDC42:GTP See in Reactome R-HSA-5665751 ( R-HSA-5663220 ) R-HSA-5665751 Reaction Name: CDC42:GTP:FMNL2 binds Profilin:G-actin See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-8950637 ( R-HSA-8950505 ) R-HSA-8950637 Reaction Name: Expression of cell division cycle 42 See in Reactome R-HSA-8951490 ( R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-8964599 ( R-HSA-8964616 ) R-HSA-8964599 Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex See in Reactome R-HSA-8964604 ( R-HSA-8964616 ) R-HSA-8964604 Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated See in Reactome R-HSA-8964614 ( R-HSA-8964616 ) R-HSA-8964614 Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated See in Reactome R-HSA-8964634 ( R-HSA-8964616 ) R-HSA-8964634 Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9013158 ( R-HSA-9013148 ) R-HSA-9013158 Reaction Name: CDC42 GDIs block activation of CDC42 See in Reactome R-HSA-9013159 ( R-HSA-9013148 ) R-HSA-9013159 Reaction Name: CDC42 GEFs activate CDC42 See in Reactome R-HSA-9013161 ( R-HSA-9013148 ) R-HSA-9013161 Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9692800 ( R-HSA-9013148 ) R-HSA-9692800 Reaction Name: CDC42 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome
MONDO:0014892	TRIO	O75962	2.7.11.1	R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Signal Transduction Developmental Biology	R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-400586 ( R-HSA-416476 ) R-HSA-400586 Reaction Name: G alpha (q) binds to Trio family RhoGEFs See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013159 ( R-HSA-9013148 ) R-HSA-9013159 Reaction Name: CDC42 GEFs activate CDC42 See in Reactome R-HSA-9014296 ( R-HSA-9013404 ) R-HSA-9014296 Reaction Name: RAC2 GEFs activate RAC2 See in Reactome R-HSA-9014433 ( R-HSA-9013408 ) R-HSA-9014433 Reaction Name: RHOG GEFs activate RHOG See in Reactome R-HSA-9017491 ( R-HSA-9013409 ) R-HSA-9017491 Reaction Name: RHOJ GEFs activate RHOJ See in Reactome R-HSA-9018804 ( R-HSA-9013423 ) R-HSA-9018804 Reaction Name: RAC3 GEFs activate RAC3 See in Reactome
MONDO:0016815	NDUFS3	O75489	7.1.1.2	R-HSA-6799198 R-HSA-6799198 Reactome Name: Complex I biogenesis See in Reactome R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome	R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-163217 ( R-HSA-611105 ) R-HSA-163217 Reaction Name: Complex I oxidises NADH to NAD+, reduces CoQ to QH2 See in Reactome R-HSA-6799178 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799178 Reaction Name: Intermediate 1 binds HP subcomplex to form Intermediate 2 See in Reactome R-HSA-6799179 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799179 Reaction Name: Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex See in Reactome R-HSA-6799191 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799191 Reaction Name: Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex See in Reactome R-HSA-6799196 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799196 Reaction Name: The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I See in Reactome R-HSA-6799197 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799197 Reaction Name: ND4, ND5 bind the 550kDa complex to form the 815kDa complex See in Reactome R-HSA-6799202 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799202 Reaction Name: The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex See in Reactome R-HSA-6799203 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799203 Reaction Name: IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 See in Reactome R-HSA-6800868 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6800868 Reaction Name: NDUF subunits bind to form the IP subcomplex See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome
MONDO:0018610	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0018663	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0018770	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0020376	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0020378	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0021548	EPHA2	P29317	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928602 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928602 Reaction Name: NGEF binds EPHA See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928642 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928646 ( R-HSA-2682334 ) R-HSA-3928646 Reaction Name: EPHAs bind EFNAs See in Reactome R-HSA-3928648 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928648 Reaction Name: SFKs phosphorylate NGEF See in Reactome R-HSA-3928651 ( R-HSA-2682334; R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-3928660 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4093327 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-4093327 Reaction Name: EPHA binds TIAM1 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0030866	SHMT2	P34897	2.1.2.1	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-5694137 ( R-HSA-196757 ) R-HSA-5694137 Reaction Name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome
MONDO:0032613	NDUFS3	O75489	7.1.1.2	R-HSA-6799198 R-HSA-6799198 Reactome Name: Complex I biogenesis See in Reactome R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome	R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-163217 ( R-HSA-611105 ) R-HSA-163217 Reaction Name: Complex I oxidises NADH to NAD+, reduces CoQ to QH2 See in Reactome R-HSA-6799178 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799178 Reaction Name: Intermediate 1 binds HP subcomplex to form Intermediate 2 See in Reactome R-HSA-6799179 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799179 Reaction Name: Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex See in Reactome R-HSA-6799191 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799191 Reaction Name: Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex See in Reactome R-HSA-6799196 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799196 Reaction Name: The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I See in Reactome R-HSA-6799197 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799197 Reaction Name: ND4, ND5 bind the 550kDa complex to form the 815kDa complex See in Reactome R-HSA-6799202 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799202 Reaction Name: The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex See in Reactome R-HSA-6799203 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799203 Reaction Name: IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 See in Reactome R-HSA-6800868 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6800868 Reaction Name: NDUF subunits bind to form the IP subcomplex See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome
MONDO:0032939	TRIO	O75962	2.7.11.1	R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Signal Transduction Developmental Biology	R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-400586 ( R-HSA-416476 ) R-HSA-400586 Reaction Name: G alpha (q) binds to Trio family RhoGEFs See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013159 ( R-HSA-9013148 ) R-HSA-9013159 Reaction Name: CDC42 GEFs activate CDC42 See in Reactome R-HSA-9014296 ( R-HSA-9013404 ) R-HSA-9014296 Reaction Name: RAC2 GEFs activate RAC2 See in Reactome R-HSA-9014433 ( R-HSA-9013408 ) R-HSA-9014433 Reaction Name: RHOG GEFs activate RHOG See in Reactome R-HSA-9017491 ( R-HSA-9013409 ) R-HSA-9017491 Reaction Name: RHOJ GEFs activate RHOJ See in Reactome R-HSA-9018804 ( R-HSA-9013423 ) R-HSA-9018804 Reaction Name: RAC3 GEFs activate RAC3 See in Reactome