DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-9013106)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005036	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0005061	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0005138	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome
MONDO:0005335	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0008214	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0008974	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0010108	STK10	O94804	2.7.11.1	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0010150	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0011996	BCR	P11274	2.7.11.1	R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome	Signal Transduction	R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-9013022 ( R-HSA-9013026 ) R-HSA-9013022 Reaction Name: RHOB GAPs stimulate RHOB GTPase activity See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9013111 ( R-HSA-9013106 ) R-HSA-9013111 Reaction Name: RHOC GAPs stimulate RHOC GTPase activity See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013159 ( R-HSA-9013148 ) R-HSA-9013159 Reaction Name: CDC42 GEFs activate CDC42 See in Reactome R-HSA-9013161 ( R-HSA-9013148 ) R-HSA-9013161 Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity See in Reactome R-HSA-9014295 ( R-HSA-9013404 ) R-HSA-9014295 Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity See in Reactome R-HSA-9014296 ( R-HSA-9013404 ) R-HSA-9014296 Reaction Name: RAC2 GEFs activate RAC2 See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome
MONDO:0013108	BCR	P11274	2.7.11.1	R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome	Signal Transduction	R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-9013022 ( R-HSA-9013026 ) R-HSA-9013022 Reaction Name: RHOB GAPs stimulate RHOB GTPase activity See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9013111 ( R-HSA-9013106 ) R-HSA-9013111 Reaction Name: RHOC GAPs stimulate RHOC GTPase activity See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013159 ( R-HSA-9013148 ) R-HSA-9013159 Reaction Name: CDC42 GEFs activate CDC42 See in Reactome R-HSA-9013161 ( R-HSA-9013148 ) R-HSA-9013161 Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity See in Reactome R-HSA-9014295 ( R-HSA-9013404 ) R-HSA-9014295 Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity See in Reactome R-HSA-9014296 ( R-HSA-9013404 ) R-HSA-9014296 Reaction Name: RAC2 GEFs activate RAC2 See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome
MONDO:0013276	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0014564	ABCD3	P28288	3.1.2.- 7.6.2.-	R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Protein localization Transport of small molecules Signal Transduction	R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0014908	CIT	O14578	2.7.11.1	R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome	Signal Transduction	R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671972 ( R-HSA-5625900 ) R-HSA-5671972 Reaction Name: CIT binds CDKN1B See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome
MONDO:0018663	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0018770	LBR	Q14739	1.3.1.70	R-HSA-191273 R-HSA-191273 Reactome Name: Cholesterol biosynthesis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Cell Cycle Signal Transduction	R-HSA-194674 ( R-HSA-191273 ) R-HSA-194674 Reaction Name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013438 ( R-HSA-9013405 ) R-HSA-9013438 Reaction Name: RHOD binds effectors at the endosome membrane See in Reactome R-HSA-9014467 ( R-HSA-9013408 ) R-HSA-9014467 Reaction Name: RHOG binds effectors at the ER membrane See in Reactome R-HSA-9018594 ( R-HSA-9022692 ) R-HSA-9018594 Reaction Name: MECP2 binds LBR See in Reactome R-HSA-9624798 ( R-HSA-2995383 ) R-HSA-9624798 Reaction Name: LBR binds KPNB1 See in Reactome R-HSA-9624800 ( R-HSA-2995383 ) R-HSA-9624800 Reaction Name: CDK1 phosphorylates LBR See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome R-HSA-9692809 ( R-HSA-9013148 ) R-HSA-9692809 Reaction Name: CDC42 binds effectors at the ER membrane See in Reactome R-HSA-9714361 ( R-HSA-9013106 ) R-HSA-9714361 Reaction Name: RHOC activates endoplasmic reticulum effectors See in Reactome R-HSA-9714481 ( R-HSA-9013404 ) R-HSA-9714481 Reaction Name: RAC2 binds effectors at the ER membrane See in Reactome R-HSA-9714691 ( R-HSA-9013423 ) R-HSA-9714691 Reaction Name: RAC3 binds ER effectors See in Reactome
MONDO:0018908	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0019086	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0021100	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0021100	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome
MONDO:0032884	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0035124	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome

Number of enzymes:	7
Number of disease:	20
Number of reactomes:	42
Number of reactions:	98

Search summary (Reactome ID: R-HSA-9013106)

Search results (Reactome ID: R-HSA-9013106)

MONDO:0005036

R-HSA-198203

R-HSA-114604

R-HSA-8849471

R-HSA-6798695

R-HSA-8980692

R-HSA-5625900

R-HSA-5625740

R-HSA-5689896

R-HSA-2173791

R-HSA-209563

R-HSA-4420097

R-HSA-193634

R-HSA-5663220

R-HSA-416482

R-HSA-5666185

R-HSA-392451

R-HSA-5627117

R-HSA-416572

R-HSA-9013106

R-HSA-416550

R-HSA-4086400

R-HSA-3928663

R-HSA-3928662

R-HSA-5625970

R-HSA-8985586

R-HSA-6785631

R-HSA-376176

R-HSA-9012999

R-HSA-168256

R-HSA-194315

R-HSA-9006927

R-HSA-193704

R-HSA-597592

R-HSA-8848021

R-HSA-1266738

R-HSA-400685

R-HSA-166520

R-HSA-194138

R-HSA-76002

R-HSA-9675108

R-HSA-73887

R-HSA-388396

R-HSA-3858494

R-HSA-170834

R-HSA-168249

R-HSA-392499

R-HSA-373755

R-HSA-9006934

R-HSA-9006936

R-HSA-2682334

R-HSA-187037

R-HSA-195258

R-HSA-195721

R-HSA-372790

R-HSA-193697

R-HSA-5688426

R-HSA-397795

R-HSA-1227986

R-HSA-422475

R-HSA-9716542

R-HSA-109582

R-HSA-162582

R-HSA-114544

R-HSA-193646

R-HSA-193668

R-HSA-193696

R-HSA-194518

R-HSA-202692

R-HSA-2134506

R-HSA-2134519

R-HSA-2134532

R-HSA-2160931

R-HSA-2160932

R-HSA-2160935

R-HSA-3858495

R-HSA-3928576

R-HSA-3928577