MONDO:0005138 |
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|
MONDO:0010108 |
STK10 |
O94804 |
2.7.11.1
|
R-HSA-6798695
R-HSA-9013106
R-HSA-9013026
R-HSA-8980692
|
R-HSA-9012999
R-HSA-168256
R-HSA-168249
R-HSA-194315
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0011996 |
BCR |
P11274 |
2.7.11.1
|
R-HSA-9013106
R-HSA-8980692
R-HSA-9013026
R-HSA-9013423
R-HSA-9013404
R-HSA-9013149
R-HSA-9013148
|
R-HSA-162582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-194315
R-HSA-9012999
|
Signal Transduction
|
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-9013022
(
R-HSA-9013026
)
R-HSA-9013022
Reaction Name: RHOB GAPs stimulate RHOB GTPase activity
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9013111
(
R-HSA-9013106
)
R-HSA-9013111
Reaction Name: RHOC GAPs stimulate RHOC GTPase activity
See in Reactome
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9013161
(
R-HSA-9013148
)
R-HSA-9013161
Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity
See in Reactome
R-HSA-9014295
(
R-HSA-9013404
)
R-HSA-9014295
Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity
See in Reactome
R-HSA-9014296
(
R-HSA-9013404
)
R-HSA-9018806
(
R-HSA-9013423
)
R-HSA-9018806
Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity
See in Reactome
|
MONDO:0013108 |
BCR |
P11274 |
2.7.11.1
|
R-HSA-9013106
R-HSA-8980692
R-HSA-9013026
R-HSA-9013423
R-HSA-9013404
R-HSA-9013149
R-HSA-9013148
|
R-HSA-162582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-194315
R-HSA-9012999
|
Signal Transduction
|
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-9013022
(
R-HSA-9013026
)
R-HSA-9013022
Reaction Name: RHOB GAPs stimulate RHOB GTPase activity
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9013111
(
R-HSA-9013106
)
R-HSA-9013111
Reaction Name: RHOC GAPs stimulate RHOC GTPase activity
See in Reactome
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9013161
(
R-HSA-9013148
)
R-HSA-9013161
Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity
See in Reactome
R-HSA-9014295
(
R-HSA-9013404
)
R-HSA-9014295
Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity
See in Reactome
R-HSA-9014296
(
R-HSA-9013404
)
R-HSA-9018806
(
R-HSA-9013423
)
R-HSA-9018806
Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity
See in Reactome
|
MONDO:0014908 |
CIT |
O14578 |
2.7.11.1
|
R-HSA-5625900
R-HSA-9013149
R-HSA-9013106
R-HSA-9013026
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-194315
R-HSA-9012999
|
Signal Transduction
|
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671972
(
R-HSA-5625900
)
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|