DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-9009391)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001056	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0002911	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005097	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005233	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005298	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0005335	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005387	NOS3	P29474	1.14.13.39	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-203754 R-HSA-203754 Reactome Name: NOSIP mediated eNOS trafficking See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-202110 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202110 Reaction Name: eNOS:Caveolin-1 complex binds to CaM See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202129 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202129 Reaction Name: HSP90 binds eNOS:Caveolin-1:CaM complex See in Reactome R-HSA-202132 ( R-HSA-203615 ) R-HSA-202132 Reaction Name: depalmitoylated eNOS translocates from plasma membrane See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-202144 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202144 Reaction Name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex See in Reactome R-HSA-203553 ( R-HSA-203754 ) R-HSA-203553 Reaction Name: eNOS binds NOSIP See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203567 ( R-HSA-203615 ) R-HSA-203567 Reaction Name: palmitoylation of eNOS See in Reactome R-HSA-203611 ( R-HSA-203615 ) R-HSA-203611 Reaction Name: N-myristoylation of eNOS See in Reactome R-HSA-203613 ( R-HSA-203615 ) R-HSA-203613 Reaction Name: depalmitoylation of eNOS See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-203680 ( R-HSA-203754 ) R-HSA-203680 Reaction Name: eNOS:NOSIP translocation from caveolae to intracellular compartments See in Reactome R-HSA-203700 ( R-HSA-203615 ) R-HSA-203700 Reaction Name: eNOS translocation from Golgi to Caveolae See in Reactome R-HSA-203712 ( R-HSA-203615 ) R-HSA-203712 Reaction Name: eNOS associates with Caveolin-1 See in Reactome R-HSA-203716 ( R-HSA-203641 ) R-HSA-203716 Reaction Name: eNOS:Caveolin-1 complex binds to Nostrin See in Reactome R-HSA-418436 ( R-HSA-1222556; R-HSA-392154 ) R-HSA-418436 Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) See in Reactome
MONDO:0005575	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0005575	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-388841; R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005575	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0005580	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0007962	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008021	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008093	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008170	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-388841; R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008170	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008315	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008318	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-388841; R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008420	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008903	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0009692	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0009809	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0010038	IGF1R	P08069	2.7.10.1	R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome	R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome	Signal Transduction	R-HSA-2404193 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404193 Reaction Name: IGF1R phosphorylates SHC1 See in Reactome R-HSA-2404195 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404195 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 See in Reactome R-HSA-2404199 ( R-HSA-2404192 ) R-HSA-2404199 Reaction Name: IGF1,2:IGF1R autophosphorylates See in Reactome R-HSA-2404200 ( R-HSA-2404192 ) R-HSA-2404200 Reaction Name: IGF1,2 binds IGF1R See in Reactome R-HSA-2428922 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428922 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 See in Reactome R-HSA-2428926 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428926 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 See in Reactome R-HSA-2428930 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428930 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 See in Reactome R-HSA-5686072 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-5686072 Reaction Name: p-3Y-SHC1 dissociates from IGF1R See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome R-HSA-9634584 ( R-HSA-9009391 ) R-HSA-9634584 Reaction Name: Estrogen receptor binds IGF1R and SHC1 in response to estrogen See in Reactome
MONDO:0010150	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0011240	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0013038	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0013113	MMP9	P14780	3.4.24.35	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1433374 ( R-HSA-1433557 ) R-HSA-1433374 Reaction Name: Processing of SCF isoform 1 See in Reactome R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602454 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602454 Reaction Name: proMMP9 binds TIMP1 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604722 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2168982 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168982 Reaction Name: Collagen type XVI degradation by MMP9 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-3827958 ( R-HSA-1474228 ) R-HSA-3827958 Reaction Name: E-cadherin degradation by MMP9, KLK7 See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0013125	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0013765	MMP3	P08254	3.4.24.17	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Signal Transduction	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604731 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604731 Reaction Name: Autocatalytic activation of MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2179402 ( R-HSA-2179392; R-HSA-416476 ) R-HSA-2179402 Reaction Name: Active MMP3 can cleave pro-HBEGF to form active HBEGF See in Reactome R-HSA-2179413 ( R-HSA-2179392; R-HSA-416476 ) R-HSA-2179413 Reaction Name: Activated PKC-alpha activate MMP3 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-2533970 ( R-HSA-1474228 ) R-HSA-2533970 Reaction Name: NID1 degradation by MMP3, 7 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-4086205 ( R-HSA-1474228 ) R-HSA-4086205 Reaction Name: OPN (osteopontin) degradation by MMP3, MMP7 See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0014047	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0014048	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-388841; R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0014481	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0014837	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0016216	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0016419	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-388841; R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016419	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0016642	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1227986; R-HSA-1358803; R-HSA-8863795 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357; R-HSA-4420097; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-388841; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-388841; R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016642	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0016996	IGF1R	P08069	2.7.10.1	R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome	R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome	Signal Transduction	R-HSA-2404193 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404193 Reaction Name: IGF1R phosphorylates SHC1 See in Reactome R-HSA-2404195 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404195 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 See in Reactome R-HSA-2404199 ( R-HSA-2404192 ) R-HSA-2404199 Reaction Name: IGF1,2:IGF1R autophosphorylates See in Reactome R-HSA-2404200 ( R-HSA-2404192 ) R-HSA-2404200 Reaction Name: IGF1,2 binds IGF1R See in Reactome R-HSA-2428922 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428922 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 See in Reactome R-HSA-2428926 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428926 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 See in Reactome R-HSA-2428930 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428930 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 See in Reactome R-HSA-5686072 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-5686072 Reaction Name: p-3Y-SHC1 dissociates from IGF1R See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome R-HSA-9634584 ( R-HSA-9009391 ) R-HSA-9634584 Reaction Name: Estrogen receptor binds IGF1R and SHC1 in response to estrogen See in Reactome
MONDO:0017177	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0017564	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0017566	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0017812	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0018177	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0018298	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0020492	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0044339	MMP9	P14780	3.4.24.35	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1433374 ( R-HSA-1433557 ) R-HSA-1433374 Reaction Name: Processing of SCF isoform 1 See in Reactome R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602454 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602454 Reaction Name: proMMP9 binds TIMP1 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604722 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2168982 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168982 Reaction Name: Collagen type XVI degradation by MMP9 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-3827958 ( R-HSA-1474228 ) R-HSA-3827958 Reaction Name: E-cadherin degradation by MMP9, KLK7 See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0044903	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome

Number of enzymes:	9
Number of disease:	43
Number of reactomes:	145
Number of reactions:	377

Search summary (Reactome ID: R-HSA-9009391)

Search results (Reactome ID: R-HSA-9009391)

MONDO:0001056

R-HSA-1660499

R-HSA-198203

R-HSA-4420097

R-HSA-114604

R-HSA-1963642

R-HSA-9607240

R-HSA-186763

R-HSA-180292

R-HSA-8853659

R-HSA-9027276

R-HSA-2730905

R-HSA-912631

R-HSA-1257604

R-HSA-5654710

R-HSA-5654720

R-HSA-5654689

R-HSA-112399

R-HSA-389357

R-HSA-388841

R-HSA-5673001

R-HSA-2029485

R-HSA-202424

R-HSA-912526

R-HSA-1433557

R-HSA-2424491

R-HSA-512988

R-HSA-5654695

R-HSA-9009391

R-HSA-9013149

R-HSA-8851907

R-HSA-1250342

R-HSA-416476

R-HSA-201556

R-HSA-109704

R-HSA-210993

R-HSA-6811558

R-HSA-9028335

R-HSA-9013404

R-HSA-9603381

R-HSA-373753

R-HSA-186797

R-HSA-9012999

R-HSA-2404192

R-HSA-168256

R-HSA-194315

R-HSA-202733

R-HSA-1500931

R-HSA-9006925

R-HSA-2428924

R-HSA-2428928

R-HSA-1236394

R-HSA-74752

R-HSA-1280218

R-HSA-1266738

R-HSA-74751

R-HSA-5654687

R-HSA-5683057

R-HSA-166520

R-HSA-194138

R-HSA-5684996

R-HSA-1430728

R-HSA-449147

R-HSA-1483257

R-HSA-1483255

R-HSA-199418

R-HSA-389356

R-HSA-388396

R-HSA-556833

R-HSA-5654708

R-HSA-109582

R-HSA-202403

R-HSA-5654741

R-HSA-9006335

R-HSA-2029480

R-HSA-190236

R-HSA-2454202

R-HSA-451927