DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8983711)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	11
Number of reactions:	44

Search results (Reactome ID: R-HSA-8983711)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011098	RNASEL	Q05823	3.1.26.-	R-HSA-8983711 R-HSA-8983711 Reactome Name: OAS antiviral response See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome	R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome	Immune System	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-5223305 ( R-HSA-909733 ) R-HSA-5223305 Reaction Name: ABCE1 binds RNASEL, inhibiting it See in Reactome R-HSA-8985123 ( R-HSA-8983711 ) R-HSA-8985123 Reaction Name: RNASEL binds 2'-5' oligoadenylate See in Reactome R-HSA-8985201 ( R-HSA-8983711 ) R-HSA-8985201 Reaction Name: ABCE1 binds RNASEL See in Reactome R-HSA-9009936 ( R-HSA-8983711 ) R-HSA-9009936 Reaction Name: RNASEL cleaves cellular ssRNA See in Reactome R-HSA-9009941 ( R-HSA-8983711 ) R-HSA-9009941 Reaction Name: RNASEL cleaves viral ssRNA See in Reactome
MONDO:0014575	DDX58	O95786	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8983711 R-HSA-8983711 Reactome Name: OAS antiviral response See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome	Immune System Metabolism of proteins	R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-168935 ( R-HSA-168928 ) R-HSA-168935 Reaction Name: viral dsRNA binds DDX58 See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5696564 ( R-HSA-5689880 ) R-HSA-5696564 Reaction Name: USP25 deubiquitinates DDX58 See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-8985153 ( R-HSA-8983711 ) R-HSA-8985153 Reaction Name: OASL binds DDX58 See in Reactome R-HSA-918224 ( R-HSA-168928 ) R-HSA-918224 Reaction Name: DDX58 is K63 polyubiquitinated See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936390 ( R-HSA-168928; R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-936563 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936563 Reaction Name: ISGylation of DDX58 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome