DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8964041)

Number of enzymes:	3
Number of disease:	4
Number of reactomes:	12
Number of reactions:	18

Search results (Reactome ID: R-HSA-8964041)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007204	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0007744	CETP	P11597	-	R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8964058 R-HSA-8964058 Reactome Name: HDL remodeling See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome	Transport of small molecules Signal Transduction	R-HSA-266328 ( R-HSA-8964058 ) R-HSA-266328 Reaction Name: CETP-mediated lipid exchange: spherical HDL gains triacylglycerol See in Reactome R-HSA-266350 ( R-HSA-8964041 ) R-HSA-266350 Reaction Name: CETP-mediated lipid exchange: LDL gains cholesterol ester See in Reactome R-HSA-349404 ( R-HSA-8964058 ) R-HSA-349404 Reaction Name: CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex See in Reactome R-HSA-9035169 ( R-HSA-9029569 ) R-HSA-9035169 Reaction Name: Expression of CETP regulated by NR1H2 or NR1H3 See in Reactome
MONDO:0008146	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0008692	MTTP	P55157	-	R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome	R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome