DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8964038)

Number of enzymes:	4
Number of disease:	13
Number of reactomes:	5
Number of reactions:	13

Search results (Reactome ID: R-HSA-8964038)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0003441	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0007750	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0009757	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0011369	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0011873	NPC2	P61916	-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Immune System Transport of small molecules	R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-8876472 ( R-HSA-8964038 ) R-HSA-8876472 Reaction Name: NPC2 binds CHOL See in Reactome R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome
MONDO:0016306	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016306	NPC2	P61916	-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Immune System Transport of small molecules	R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-8876472 ( R-HSA-8964038 ) R-HSA-8876472 Reaction Name: NPC2 binds CHOL See in Reactome R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome
MONDO:0016307	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016307	NPC2	P61916	-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Immune System Transport of small molecules	R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-8876472 ( R-HSA-8964038 ) R-HSA-8876472 Reaction Name: NPC2 binds CHOL See in Reactome R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome
MONDO:0016308	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016308	NPC2	P61916	-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Immune System Transport of small molecules	R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-8876472 ( R-HSA-8964038 ) R-HSA-8876472 Reaction Name: NPC2 binds CHOL See in Reactome R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome
MONDO:0016309	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016309	NPC2	P61916	-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Immune System Transport of small molecules	R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-8876472 ( R-HSA-8964038 ) R-HSA-8876472 Reaction Name: NPC2 binds CHOL See in Reactome R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome
MONDO:0016310	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016310	NPC2	P61916	-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Immune System Transport of small molecules	R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-8876472 ( R-HSA-8964038 ) R-HSA-8876472 Reaction Name: NPC2 binds CHOL See in Reactome R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome
MONDO:0018328	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0019148	LIPA	P38571	3.1.1.13	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8865667 ( R-HSA-8964038 ) R-HSA-8865667 Reaction Name: LIPA hydrolyses sterol esters to sterols and fatty acids See in Reactome
MONDO:0019149	LIPA	P38571	3.1.1.13	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8865667 ( R-HSA-8964038 ) R-HSA-8865667 Reaction Name: LIPA hydrolyses sterol esters to sterols and fatty acids See in Reactome