DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8963889)

Number of enzymes:	5
Number of disease:	11
Number of reactomes:	11
Number of reactions:	29

Search results (Reactome ID: R-HSA-8963889)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007759	LPL	P06858	3.1.1.34 3.1.1.32	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8963901 R-HSA-8963901 Reactome Name: Chylomicron remodeling See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Sensory Perception Metabolism Developmental Biology	R-HSA-174757 ( R-HSA-8963901 ) R-HSA-174757 Reaction Name: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols See in Reactome R-HSA-2395768 ( R-HSA-975634 ) R-HSA-2395768 Reaction Name: LPL hydrolyses TGs from mature CMs See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-6784628 ( R-HSA-8963889 ) R-HSA-6784628 Reaction Name: PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784676 ( R-HSA-8963889 ) R-HSA-6784676 Reaction Name: PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784861 ( R-HSA-8963889 ) R-HSA-6784861 Reaction Name: HSPG binds LPL dimer See in Reactome R-HSA-8857928 ( R-HSA-8963889 ) R-HSA-8857928 Reaction Name: GPIHBP1 binds HSPG:LPL dimer See in Reactome
MONDO:0009387	LPL	P06858	3.1.1.34 3.1.1.32	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8963901 R-HSA-8963901 Reactome Name: Chylomicron remodeling See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Sensory Perception Metabolism Developmental Biology	R-HSA-174757 ( R-HSA-8963901 ) R-HSA-174757 Reaction Name: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols See in Reactome R-HSA-2395768 ( R-HSA-975634 ) R-HSA-2395768 Reaction Name: LPL hydrolyses TGs from mature CMs See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-6784628 ( R-HSA-8963889 ) R-HSA-6784628 Reaction Name: PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784676 ( R-HSA-8963889 ) R-HSA-6784676 Reaction Name: PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784861 ( R-HSA-8963889 ) R-HSA-6784861 Reaction Name: HSPG binds LPL dimer See in Reactome R-HSA-8857928 ( R-HSA-8963889 ) R-HSA-8857928 Reaction Name: GPIHBP1 binds HSPG:LPL dimer See in Reactome
MONDO:0010486	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0010637	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0013533	LIPC	P11150	3.1.1.5 3.1.1.32 3.1.1.3	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8964026 R-HSA-8964026 Reactome Name: Chylomicron clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome	Transport of small molecules	R-HSA-174657 ( R-HSA-8964026 ) R-HSA-174657 Reaction Name: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex See in Reactome R-HSA-5694109 ( R-HSA-8963889 ) R-HSA-5694109 Reaction Name: LIPC dimer hydrolyses TAG to DAG and FA See in Reactome R-HSA-6785178 ( R-HSA-8963889 ) R-HSA-6785178 Reaction Name: LMF1,2 transport LIPC dimer from ER lumen to extracellular region See in Reactome R-HSA-6785181 ( R-HSA-8963889 ) R-HSA-6785181 Reaction Name: LMF1,2 bind LIPC dimer See in Reactome R-HSA-6785213 ( R-HSA-8963889 ) R-HSA-6785213 Reaction Name: LIPC dimer binds heparin See in Reactome
MONDO:0014098	CIDEC	Q96AQ7	-	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8964572 R-HSA-8964572 Reactome Name: Lipid particle organization See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Metabolism Transport of small molecules	R-HSA-8856630 ( R-HSA-8964572 ) R-HSA-8856630 Reaction Name: CIDEA:CIDEC binds lipid droplets See in Reactome
MONDO:0019414	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0032721	MBTPS1	Q14703	3.4.21.112	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Cellular responses to stimuli Metabolism of proteins Metabolism Transport of small molecules	R-HSA-1655842 ( R-HSA-1655829 ) R-HSA-1655842 Reaction Name: S1P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-381135 ( R-HSA-381033 ) R-HSA-381135 Reaction Name: MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874186 ( R-HSA-8874211 ) R-HSA-8874186 Reaction Name: MBTPS1 (S1P) cleaves CREB3L4 See in Reactome R-HSA-8874204 ( R-HSA-8874211 ) R-HSA-8874204 Reaction Name: MBTPS1 (S1P) cleaves CREB3 See in Reactome R-HSA-8874205 ( R-HSA-8874211 ) R-HSA-8874205 Reaction Name: MBTPS1 (S1P) cleaves CREB3L2 See in Reactome R-HSA-8874206 ( R-HSA-8874211 ) R-HSA-8874206 Reaction Name: MBTPS1 (S1P) cleaves CREB3L3 See in Reactome R-HSA-8874212 ( R-HSA-8874211 ) R-HSA-8874212 Reaction Name: MBTPS1 (S1P) cleaves CREB3L1 See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0049223	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0100213	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0100296	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome