DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8963693)

Number of enzymes:	4
Number of disease:	5
Number of reactomes:	8
Number of reactions:	8

Search results (Reactome ID: R-HSA-8963693)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013549	NAT8L	Q8N9F0	2.3.1.17	R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-8954468 ( R-HSA-8963693 ) R-HSA-8954468 Reaction Name: NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA See in Reactome
MONDO:0014258	ASNS	P08243	6.3.5.4	R-HSA-9633012 R-HSA-9633012 Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-9648895 R-HSA-9648895 Reactome Name: Response of EIF2AK1 (HRI) to heme deficiency See in Reactome R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome	Cellular responses to stimuli Metabolism	R-HSA-1791118 ( R-HSA-380994; R-HSA-9633012; R-HSA-9648895 ) R-HSA-1791118 Reaction Name: Expression of ASNS (Asparagine Synthetase) See in Reactome R-HSA-70599 ( R-HSA-8963693 ) R-HSA-70599 Reaction Name: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] See in Reactome
MONDO:0017830	ASPA	P45381	3.5.1.15	R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-5691507 ( R-HSA-8963693 ) R-HSA-5691507 Reaction Name: ASPA deacetylates NAA to acetate and L-aspartate See in Reactome
MONDO:0017831	ASPA	P45381	3.5.1.15	R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-5691507 ( R-HSA-8963693 ) R-HSA-5691507 Reaction Name: ASPA deacetylates NAA to acetate and L-aspartate See in Reactome
MONDO:0032880	GOT2	P00505	2.6.1.7 2.6.1.1	R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-8964539 R-HSA-8964539 Reactome Name: Glutamate and glutamine metabolism See in Reactome R-HSA-1614558 R-HSA-1614558 Reactome Name: Degradation of cysteine and homocysteine See in Reactome R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-6784393 ( R-HSA-389661 ) R-HSA-6784393 Reaction Name: PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) See in Reactome R-HSA-70596 ( R-HSA-8963693 ) R-HSA-70596 Reaction Name: GOT2 dimer deaminates L-Asp See in Reactome R-HSA-70613 ( R-HSA-70263; R-HSA-8964539 ) R-HSA-70613 Reaction Name: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] See in Reactome R-HSA-9012597 ( R-HSA-1614558 ) R-HSA-9012597 Reaction Name: GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu See in Reactome