DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8953750)

Number of enzymes:	4
Number of disease:	10
Number of reactomes:	26
Number of reactions:	101

Search results (Reactome ID: R-HSA-8953750)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009215	BRCA1	P38398	2.3.2.27	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1221632 R-HSA-1221632 Reactome Name: Meiotic synapsis See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle Reproduction	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-5659781 ( R-HSA-5693565 ) R-HSA-5659781 Reaction Name: BRCA1 forms a heterodimer with BARD1 See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5691411 ( R-HSA-5689901 ) R-HSA-5691411 Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9007605 ( R-HSA-8953750 ) R-HSA-9007605 Reaction Name: BRCA1 gene expression is inhibited by E2F6 See in Reactome R-HSA-912450 ( R-HSA-1221632 ) R-HSA-912450 Reaction Name: ATR Kinase is recruited to unsynapsed regions See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912467 ( R-HSA-1221632 ) R-HSA-912467 Reaction Name: BRCA1 is recruited to unsynapsed regions See in Reactome R-HSA-912470 ( R-HSA-1221632 ) R-HSA-912470 Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome R-HSA-9707051 ( R-HSA-5693565 ) R-HSA-9707051 Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0009622	RBBP8	Q99708	3.1.-.-	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle Reproduction	R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685953 ( R-HSA-5693607 ) R-HSA-5685953 Reaction Name: SIRT6 deacetylates RBBP8 See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-9007625 ( R-HSA-8953750 ) R-HSA-9007625 Reaction Name: RBBP8 gene expression is inhibited by E2F6 See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0010193	EZH2	Q15910	2.1.1.356	R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-212300 R-HSA-212300 Reactome Name: PRC2 methylates histones and DNA See in Reactome R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Cellular responses to stimuli Chromatin organization Signal Transduction Gene expression (Transcription) Developmental Biology	R-HSA-212222 ( R-HSA-212300 ) R-HSA-212222 Reaction Name: PRC2 recruits DNA methyltransferases See in Reactome R-HSA-212252 ( R-HSA-212300 ) R-HSA-212252 Reaction Name: Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin See in Reactome R-HSA-212263 ( R-HSA-212300 ) R-HSA-212263 Reaction Name: PRC2 trimethylates histone H3 at lysine-27 See in Reactome R-HSA-212269 ( R-HSA-212300 ) R-HSA-212269 Reaction Name: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 See in Reactome R-HSA-3240295 ( R-HSA-2559580 ) R-HSA-3240295 Reaction Name: PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter See in Reactome R-HSA-3240783 ( R-HSA-2559580 ) R-HSA-3240783 Reaction Name: E2F1/2/3 stimulates EZH2 transcription See in Reactome R-HSA-3240957 ( R-HSA-2559580 ) R-HSA-3240957 Reaction Name: Formation of PRC2-EZH2 complex See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617445 ( R-HSA-5617472 ) R-HSA-5617445 Reaction Name: HOXD1 chromatin is activated See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-5617650 ( R-HSA-5617472 ) R-HSA-5617650 Reaction Name: HOXD3 chromatin is activated See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-5638332 ( R-HSA-3214841 ) R-HSA-5638332 Reaction Name: PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) See in Reactome R-HSA-6810139 ( R-HSA-5617472 ) R-HSA-6810139 Reaction Name: HOXA2 chromatin is activated See in Reactome R-HSA-6810158 ( R-HSA-5617472 ) R-HSA-6810158 Reaction Name: HOXB3 chromatin is activated See in Reactome R-HSA-6810159 ( R-HSA-5617472 ) R-HSA-6810159 Reaction Name: HOXB2 chromatin is activated See in Reactome R-HSA-6810161 ( R-HSA-5617472 ) R-HSA-6810161 Reaction Name: HOXA3 chromatin is activated See in Reactome R-HSA-8943817 ( R-HSA-8943724 ) R-HSA-8943817 Reaction Name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter See in Reactome R-HSA-8944104 ( R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-8954110 ( R-HSA-8953750 ) R-HSA-8954110 Reaction Name: E2F6:TFDP1:EPC1 binds the PRC2 complex See in Reactome
MONDO:0011450	BRCA1	P38398	2.3.2.27	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1221632 R-HSA-1221632 Reactome Name: Meiotic synapsis See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle Reproduction	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-5659781 ( R-HSA-5693565 ) R-HSA-5659781 Reaction Name: BRCA1 forms a heterodimer with BARD1 See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5691411 ( R-HSA-5689901 ) R-HSA-5691411 Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9007605 ( R-HSA-8953750 ) R-HSA-9007605 Reaction Name: BRCA1 gene expression is inhibited by E2F6 See in Reactome R-HSA-912450 ( R-HSA-1221632 ) R-HSA-912450 Reaction Name: ATR Kinase is recruited to unsynapsed regions See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912467 ( R-HSA-1221632 ) R-HSA-912467 Reaction Name: BRCA1 is recruited to unsynapsed regions See in Reactome R-HSA-912470 ( R-HSA-1221632 ) R-HSA-912470 Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome R-HSA-9707051 ( R-HSA-5693565 ) R-HSA-9707051 Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0011715	RBBP8	Q99708	3.1.-.-	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle Reproduction	R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685953 ( R-HSA-5693607 ) R-HSA-5685953 Reaction Name: SIRT6 deacetylates RBBP8 See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-9007625 ( R-HSA-8953750 ) R-HSA-9007625 Reaction Name: RBBP8 gene expression is inhibited by E2F6 See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0013685	BRCA1	P38398	2.3.2.27	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1221632 R-HSA-1221632 Reactome Name: Meiotic synapsis See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle Reproduction	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-5659781 ( R-HSA-5693565 ) R-HSA-5659781 Reaction Name: BRCA1 forms a heterodimer with BARD1 See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5691411 ( R-HSA-5689901 ) R-HSA-5691411 Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9007605 ( R-HSA-8953750 ) R-HSA-9007605 Reaction Name: BRCA1 gene expression is inhibited by E2F6 See in Reactome R-HSA-912450 ( R-HSA-1221632 ) R-HSA-912450 Reaction Name: ATR Kinase is recruited to unsynapsed regions See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912467 ( R-HSA-1221632 ) R-HSA-912467 Reaction Name: BRCA1 is recruited to unsynapsed regions See in Reactome R-HSA-912470 ( R-HSA-1221632 ) R-HSA-912470 Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome R-HSA-9707051 ( R-HSA-5693565 ) R-HSA-9707051 Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0015278	BRCA1	P38398	2.3.2.27	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1221632 R-HSA-1221632 Reactome Name: Meiotic synapsis See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle Reproduction	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-5659781 ( R-HSA-5693565 ) R-HSA-5659781 Reaction Name: BRCA1 forms a heterodimer with BARD1 See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5691411 ( R-HSA-5689901 ) R-HSA-5691411 Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9007605 ( R-HSA-8953750 ) R-HSA-9007605 Reaction Name: BRCA1 gene expression is inhibited by E2F6 See in Reactome R-HSA-912450 ( R-HSA-1221632 ) R-HSA-912450 Reaction Name: ATR Kinase is recruited to unsynapsed regions See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912467 ( R-HSA-1221632 ) R-HSA-912467 Reaction Name: BRCA1 is recruited to unsynapsed regions See in Reactome R-HSA-912470 ( R-HSA-1221632 ) R-HSA-912470 Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome R-HSA-9707051 ( R-HSA-5693565 ) R-HSA-9707051 Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0015278	RBBP8	Q99708	3.1.-.-	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle Reproduction	R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685953 ( R-HSA-5693607 ) R-HSA-5685953 Reaction Name: SIRT6 deacetylates RBBP8 See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-9007625 ( R-HSA-8953750 ) R-HSA-9007625 Reaction Name: RBBP8 gene expression is inhibited by E2F6 See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0016865	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0027407	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0054748	BRCA1	P38398	2.3.2.27	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1221632 R-HSA-1221632 Reactome Name: Meiotic synapsis See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle Reproduction	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-5659781 ( R-HSA-5693565 ) R-HSA-5659781 Reaction Name: BRCA1 forms a heterodimer with BARD1 See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5691411 ( R-HSA-5689901 ) R-HSA-5691411 Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9007605 ( R-HSA-8953750 ) R-HSA-9007605 Reaction Name: BRCA1 gene expression is inhibited by E2F6 See in Reactome R-HSA-912450 ( R-HSA-1221632 ) R-HSA-912450 Reaction Name: ATR Kinase is recruited to unsynapsed regions See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912467 ( R-HSA-1221632 ) R-HSA-912467 Reaction Name: BRCA1 is recruited to unsynapsed regions See in Reactome R-HSA-912470 ( R-HSA-1221632 ) R-HSA-912470 Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome R-HSA-9707051 ( R-HSA-5693565 ) R-HSA-9707051 Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer See in Reactome