DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8949664)

Number of enzymes:	4
Number of disease:	7
Number of reactomes:	2
Number of reactions:	6

Search results (Reactome ID: R-HSA-8949664)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011803	SPG7	Q9UQ90	3.4.24.-	R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Transport of small molecules	R-HSA-8949649 ( R-HSA-8949664 ) R-HSA-8949649 Reaction Name: PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) See in Reactome R-HSA-8949659 ( R-HSA-8949664 ) R-HSA-8949659 Reaction Name: AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU See in Reactome R-HSA-8949661 ( R-HSA-8949664 ) R-HSA-8949661 Reaction Name: C2orf47:AFG3L2 binds the transit peptide of SMDT1 See in Reactome
MONDO:0012450	AFG3L2	Q9Y4W6	3.4.24.-	R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Transport of small molecules	R-HSA-8949649 ( R-HSA-8949664 ) R-HSA-8949649 Reaction Name: PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) See in Reactome R-HSA-8949659 ( R-HSA-8949664 ) R-HSA-8949659 Reaction Name: AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU See in Reactome R-HSA-8949661 ( R-HSA-8949664 ) R-HSA-8949661 Reaction Name: C2orf47:AFG3L2 binds the transit peptide of SMDT1 See in Reactome
MONDO:0013776	AFG3L2	Q9Y4W6	3.4.24.-	R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Transport of small molecules	R-HSA-8949649 ( R-HSA-8949664 ) R-HSA-8949649 Reaction Name: PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) See in Reactome R-HSA-8949659 ( R-HSA-8949664 ) R-HSA-8949659 Reaction Name: AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU See in Reactome R-HSA-8949661 ( R-HSA-8949664 ) R-HSA-8949661 Reaction Name: C2orf47:AFG3L2 binds the transit peptide of SMDT1 See in Reactome
MONDO:0015011	YME1L1	Q96TA2	3.4.24.-	R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Transport of small molecules	R-HSA-8949668 ( R-HSA-8949664 ) R-HSA-8949668 Reaction Name: YME1L1 proteolyzes unassembled proSMDT1 See in Reactome
MONDO:0018155	SPG7	Q9UQ90	3.4.24.-	R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Transport of small molecules	R-HSA-8949649 ( R-HSA-8949664 ) R-HSA-8949649 Reaction Name: PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) See in Reactome R-HSA-8949659 ( R-HSA-8949664 ) R-HSA-8949659 Reaction Name: AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU See in Reactome R-HSA-8949661 ( R-HSA-8949664 ) R-HSA-8949661 Reaction Name: C2orf47:AFG3L2 binds the transit peptide of SMDT1 See in Reactome
MONDO:0033549	AFG3L2	Q9Y4W6	3.4.24.-	R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Transport of small molecules	R-HSA-8949649 ( R-HSA-8949664 ) R-HSA-8949649 Reaction Name: PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) See in Reactome R-HSA-8949659 ( R-HSA-8949664 ) R-HSA-8949659 Reaction Name: AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU See in Reactome R-HSA-8949661 ( R-HSA-8949664 ) R-HSA-8949661 Reaction Name: C2orf47:AFG3L2 binds the transit peptide of SMDT1 See in Reactome
MONDO:0054785	PMPCB	O75439	3.4.24.64	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-8949664 R-HSA-8949664 Reactome Name: Processing of SMDT1 See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8949215 R-HSA-8949215 Reactome Name: Mitochondrial calcium ion transport See in Reactome	Protein localization Transport of small molecules	R-HSA-1299476 ( R-HSA-1268020 ) R-HSA-1299476 Reaction Name: MPP cleaves targeting peptide (presequence) of inner membrane precursors See in Reactome R-HSA-1299478 ( R-HSA-1268020 ) R-HSA-1299478 Reaction Name: MPP cleaves targeting peptide (presequence) of matrix precursors See in Reactome R-HSA-8949649 ( R-HSA-8949664 ) R-HSA-8949649 Reaction Name: PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) See in Reactome