MONDO:0000087 |
MONDO:0000087
Disease Name: polymicrogyria
Orphanet id: Orphanet:35981
All associated enzymes in DAR:
AKT3
. The disease is also associated to other non-enzyme proteins (not in DAR).
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0000561 |
STUB1 |
Q9UNE7 |
2.3.2.27
|
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
|
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-5218859
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-6807070
R-HSA-1227986
R-HSA-5357801
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Programmed Cell Death
Signal Transduction
|
R-HSA-1918092
(
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-2187368
(
R-HSA-2173788
)
R-HSA-2187368
Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3
See in Reactome
R-HSA-2187375
(
R-HSA-2173788
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-9009308
(
R-HSA-8939902
)
R-HSA-9009309
(
R-HSA-8939902
)
R-HSA-9688831
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688831
Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363
See in Reactome
R-HSA-9688838
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0002407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005148 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005233 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005335 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
|