DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-8943723)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005595	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0007924	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0008021	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0008170	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0008318	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0010172	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011537	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011738	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011789	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011962	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0013092	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0015293	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0016995	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0017571	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0018338	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0018872	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0019002	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0021067	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0021427	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0023122	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0030897	AGO2	Q9UKV8	3.1.26.n2	R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-426486 R-HSA-426486 Reactome Name: Small interfering RNA (siRNA) biogenesis See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8948700 R-HSA-8948700 Reactome Name: Competing endogenous RNAs (ceRNAs) regulate PTEN translation See in Reactome R-HSA-203927 R-HSA-203927 Reactome Name: MicroRNA (miRNA) biogenesis See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-426496 R-HSA-426496 Reactome Name: Post-transcriptional silencing by small RNAs See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1606561 ( R-HSA-1912408 ) R-HSA-1606561 Reaction Name: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA See in Reactome R-HSA-1606682 ( R-HSA-1912408 ) R-HSA-1606682 Reaction Name: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA See in Reactome R-HSA-1912362 ( R-HSA-1912408 ) R-HSA-1912362 Reaction Name: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA See in Reactome R-HSA-1912363 ( R-HSA-1912408 ) R-HSA-1912363 Reaction Name: MIR200B/C microRNAs bind NOTCH1 mRNA See in Reactome R-HSA-1912364 ( R-HSA-1912408 ) R-HSA-1912364 Reaction Name: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA See in Reactome R-HSA-1912366 ( R-HSA-1912408 ) R-HSA-1912366 Reaction Name: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA See in Reactome R-HSA-1912367 ( R-HSA-1912408 ) R-HSA-1912367 Reaction Name: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA See in Reactome R-HSA-1912368 ( R-HSA-1912408 ) R-HSA-1912368 Reaction Name: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA See in Reactome R-HSA-1912406 ( R-HSA-1912408 ) R-HSA-1912406 Reaction Name: p53 positively regulates transcription of MIR34 microRNAs See in Reactome R-HSA-1912409 ( R-HSA-1912408 ) R-HSA-1912409 Reaction Name: NOTCH3 mRNA translation controlled by miRNAs See in Reactome R-HSA-1912410 ( R-HSA-1912408 ) R-HSA-1912410 Reaction Name: NOTCH4 mRNA translation controlled by miRNAs See in Reactome R-HSA-1912412 ( R-HSA-1912408 ) R-HSA-1912412 Reaction Name: NOTCH1 mRNA translation controlled by miRNAs See in Reactome R-HSA-1912413 ( R-HSA-1912408 ) R-HSA-1912413 Reaction Name: NOTCH2 mRNA translation controlled by miRNAs See in Reactome R-HSA-203862 ( R-HSA-203927 ) R-HSA-203862 Reaction Name: Dicer cleaves pre-miRNA to yield duplex miRNA See in Reactome R-HSA-2106614 ( R-HSA-203927 ) R-HSA-2106614 Reaction Name: Duplex miRNA is loaded into Argonaute See in Reactome R-HSA-2106615 ( R-HSA-426486 ) R-HSA-2106615 Reaction Name: Removal of siRNA passenger strand See in Reactome R-HSA-2106625 ( R-HSA-426486 ) R-HSA-2106625 Reaction Name: Duplex siRNA is loaded into Argonaute See in Reactome R-HSA-210805 ( R-HSA-203927 ) R-HSA-210805 Reaction Name: Removal of miRNA passenger strand See in Reactome R-HSA-2318752 ( R-HSA-5628897; R-HSA-8943723 ) R-HSA-2318752 Reaction Name: miR-26A microRNAs bind PTEN mRNA See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-426464 ( R-HSA-426486 ) R-HSA-426464 Reaction Name: Dicer cleaves double-stranded RNA to yield double-stranded siRNA See in Reactome R-HSA-426489 ( R-HSA-426496 ) R-HSA-426489 Reaction Name: RISC binds inexactly matching target RNAs See in Reactome R-HSA-426520 ( R-HSA-426496 ) R-HSA-426520 Reaction Name: Endonucleolytic RISC hydrolyzes target RNAs See in Reactome R-HSA-4518575 ( R-HSA-4086398 ) R-HSA-4518575 Reaction Name: miR-92b binds 3'UTR of NLK mRNA See in Reactome R-HSA-4518585 ( R-HSA-4086398 ) R-HSA-4518585 Reaction Name: NLK mRNA translation controlled by miR-92b See in Reactome R-HSA-5578712 ( R-HSA-5578749 ) R-HSA-5578712 Reaction Name: Importin-8 binds AGO2:miRNA See in Reactome R-HSA-5578742 ( R-HSA-5578749 ) R-HSA-5578742 Reaction Name: AGO1,2:small RNA complexes interact with chromatin See in Reactome R-HSA-5578744 ( R-HSA-5578749 ) R-HSA-5578744 Reaction Name: Importin-8 imports AGO2:miRNA into the nucleus See in Reactome R-HSA-5578965 ( R-HSA-5578749 ) R-HSA-5578965 Reaction Name: TNRC6A binds AGO2:miRNA See in Reactome R-HSA-5578966 ( R-HSA-5578749 ) R-HSA-5578966 Reaction Name: TNRC6A:AGO2:miRNA is transported into the nucleus See in Reactome R-HSA-5687103 ( R-HSA-5687128 ) R-HSA-5687103 Reaction Name: FOXO3 regulates MIR34B,C expression See in Reactome R-HSA-5687113 ( R-HSA-5687128 ) R-HSA-5687113 Reaction Name: MYC mRNA translation is negatively regulated by miR-34B and C See in Reactome R-HSA-8935785 ( R-HSA-8934593 ) R-HSA-8935785 Reaction Name: RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 See in Reactome R-HSA-8935864 ( R-HSA-8934593 ) R-HSA-8935864 Reaction Name: miR-302b binds RUNX1 mRNA See in Reactome R-HSA-8935930 ( R-HSA-8934593 ) R-HSA-8935930 Reaction Name: miR-18a binds RUNX1 mRNA See in Reactome R-HSA-8936058 ( R-HSA-8934593 ) R-HSA-8936058 Reaction Name: miR-675 binds RUNX1 mRNA See in Reactome R-HSA-8936068 ( R-HSA-8934593 ) R-HSA-8936068 Reaction Name: H19 is cleaved to produce miR-675 See in Reactome R-HSA-8939129 ( R-HSA-8934593 ) R-HSA-8939129 Reaction Name: miR-215 binds RUNX1 mRNA See in Reactome R-HSA-8944483 ( R-HSA-8943723 ) R-HSA-8944483 Reaction Name: miR-17 microRNA binds PTEN mRNA See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8944522 ( R-HSA-8943723 ) R-HSA-8944522 Reaction Name: miR-19a microRNA binds PTEN mRNA See in Reactome R-HSA-8944538 ( R-HSA-8943723 ) R-HSA-8944538 Reaction Name: miR-22 microRNA binds PTEN mRNA See in Reactome R-HSA-8944569 ( R-HSA-8943723 ) R-HSA-8944569 Reaction Name: miR-25 microRNA binds PTEN mRNA See in Reactome R-HSA-8944599 ( R-HSA-8943723 ) R-HSA-8944599 Reaction Name: miR-93 microRNA binds PTEN mRNA See in Reactome R-HSA-8944632 ( R-HSA-8943723 ) R-HSA-8944632 Reaction Name: miR-106 microRNAs bind PTEN mRNA See in Reactome R-HSA-8944684 ( R-HSA-8943723 ) R-HSA-8944684 Reaction Name: miR-205 microRNA binds PTEN mRNA See in Reactome R-HSA-8945709 ( R-HSA-8943723 ) R-HSA-8945709 Reaction Name: miR-20 microRNAs bind PTEN mRNA See in Reactome R-HSA-8948524 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948524 Reaction Name: PTENP1 mRNA binds miR-19b RISC See in Reactome R-HSA-8948536 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948536 Reaction Name: PTENP1 mRNA binds miR-20 RISC See in Reactome R-HSA-8948569 ( R-HSA-8943723 ) R-HSA-8948569 Reaction Name: miR-19b microRNA binds PTEN mRNA See in Reactome R-HSA-8948582 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948582 Reaction Name: miR-17 microRNA binds VAPA mRNA See in Reactome R-HSA-8948583 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948583 Reaction Name: miR-17 microRNA binds CNOT6L mRNA See in Reactome R-HSA-8948594 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948594 Reaction Name: miR-19a microRNA binds VAPA mRNA See in Reactome R-HSA-8948602 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948602 Reaction Name: miR-19a microRNA binds CNOT6L mRNA See in Reactome R-HSA-8948612 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948612 Reaction Name: miR-19b microRNA binds CNOT6L mRNA See in Reactome R-HSA-8948621 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948621 Reaction Name: miR-20 microRNAs bind VAPA mRNA See in Reactome R-HSA-8948623 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948623 Reaction Name: miR-20 microRNAs bind CNOT6L mRNA See in Reactome R-HSA-8948641 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948641 Reaction Name: miR-106 microRNAs bind VAPA mRNA See in Reactome R-HSA-8948651 ( R-HSA-8943723; R-HSA-8948700 ) R-HSA-8948651 Reaction Name: miR-106a,(miR106b) microRNA binds CNOT6L mRNA See in Reactome R-HSA-9011958 ( R-HSA-9018519 ) R-HSA-9011958 Reaction Name: miR-26A and B bind to the 3'UTR of the GREB1 mRNA See in Reactome R-HSA-9011961 ( R-HSA-9018519 ) R-HSA-9011961 Reaction Name: GREB1 translation is negatively regulated by miR-26A and B See in Reactome R-HSA-9012186 ( R-HSA-9018519 ) R-HSA-9012186 Reaction Name: CHD1 translation is negatively regulated by miR-26A and B See in Reactome R-HSA-9012196 ( R-HSA-9018519 ) R-HSA-9012196 Reaction Name: KPNA2 translation is negatively regulated by miR-26A and B See in Reactome R-HSA-9012203 ( R-HSA-9018519 ) R-HSA-9012203 Reaction Name: miR-26A and B bind to the 3'UTR of the CHD11 mRNA See in Reactome R-HSA-9012208 ( R-HSA-9018519 ) R-HSA-9012208 Reaction Name: miR-26A and B bind to the 3'UTR of the KPNA2 mRNA See in Reactome R-HSA-9021182 ( R-HSA-8986944; R-HSA-9022692 ) R-HSA-9021182 Reaction Name: MECP2 mRNA binds miR-132 RISC See in Reactome R-HSA-9021183 ( R-HSA-8986944; R-HSA-9022692 ) R-HSA-9021183 Reaction Name: MECP2 mRNA translation is inhibited by miR-132 See in Reactome R-HSA-9023909 ( R-HSA-426486 ) R-HSA-9023909 Reaction Name: C3PO hydrolyzes cleaved passenger strand See in Reactome R-HSA-9023912 ( R-HSA-426486 ) R-HSA-9023912 Reaction Name: AGO2 cleaves passenger strand of duplex siRNA See in Reactome R-HSA-9038545 ( R-HSA-9029569 ) R-HSA-9038545 Reaction Name: miR-613 binds to the 3'UTR of the NR1H3 mRNA See in Reactome R-HSA-9605052 ( R-HSA-9029569 ) R-HSA-9605052 Reaction Name: NR1H3 mRNA is translated See in Reactome R-HSA-9615501 ( R-HSA-8986944; R-HSA-9022692 ) R-HSA-9615501 Reaction Name: MIR132 gene expression is stimulated by p-S133-CREB1 See in Reactome R-HSA-9615554 ( R-HSA-8986944 ) R-HSA-9615554 Reaction Name: MIR137 gene expression is inhibited by MECP2 and SOX2 See in Reactome R-HSA-9615570 ( R-HSA-8986944 ) R-HSA-9615570 Reaction Name: miR-137 binds PTEN mRNA See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome R-HSA-9618392 ( R-HSA-9029569 ) R-HSA-9618392 Reaction Name: miR-26 binds to the 3'UTR of the ARL4C mRNA See in Reactome R-HSA-9618405 ( R-HSA-9029569 ) R-HSA-9618405 Reaction Name: ARL4C mRNA is translated See in Reactome R-HSA-9618479 ( R-HSA-9029569 ) R-HSA-9618479 Reaction Name: ABCA1 mRNA is translated See in Reactome R-HSA-9618486 ( R-HSA-9029569 ) R-HSA-9618486 Reaction Name: miR-26 binds to the 3'UTR of the ABCA1 mRNA See in Reactome R-HSA-9624925 ( R-HSA-9029569 ) R-HSA-9624925 Reaction Name: miR-33 binds to the 3'UTR of the ABCA1 mRNA See in Reactome R-HSA-9657791 ( R-HSA-9029569 ) R-HSA-9657791 Reaction Name: miR-144 binds to the 3'UTR of the ABCA1 mRNA See in Reactome
MONDO:0044638	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0044704	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0044705	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0044740	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome

Number of enzymes:	2
Number of disease:	25
Number of reactomes:	23
Number of reactions:	102

Search summary (Reactome ID: R-HSA-8943723)

Search results (Reactome ID: R-HSA-8943723)

MONDO:0005595

R-HSA-1660499

R-HSA-202424

R-HSA-1855204

R-HSA-5689896

R-HSA-199418

R-HSA-5689880

R-HSA-8986944

R-HSA-8948747

R-HSA-8948751

R-HSA-5628897

R-HSA-8943723

R-HSA-1483249

R-HSA-3700989

R-HSA-1257604

R-HSA-212436

R-HSA-74160

R-HSA-168256

R-HSA-1483257

R-HSA-392499

R-HSA-1483255

R-HSA-202403

R-HSA-9006925

R-HSA-1430728

R-HSA-5688426

R-HSA-6807070

R-HSA-556833

R-HSA-597592

R-HSA-1280218

R-HSA-162582

R-HSA-73857

R-HSA-1676149

R-HSA-1855205

R-HSA-199456

R-HSA-2321904

R-HSA-5689950

R-HSA-6807105

R-HSA-6807106

R-HSA-6807118

R-HSA-6807126

R-HSA-6807134

R-HSA-6807206

R-HSA-8847968

R-HSA-8847977

R-HSA-8850945

R-HSA-8850961

R-HSA-8850992

R-HSA-8850997

R-HSA-8851011

R-HSA-8873946

R-HSA-8944497

R-HSA-8948775

R-HSA-8948800

R-HSA-8948832

R-HSA-9615571

MONDO:0007924

R-HSA-1660499

R-HSA-202424

R-HSA-1855204

R-HSA-5689896

R-HSA-199418

R-HSA-5689880

R-HSA-8986944

R-HSA-8948747

R-HSA-8948751

R-HSA-5628897

R-HSA-8943723

R-HSA-1483249

R-HSA-3700989

R-HSA-1257604

R-HSA-212436

R-HSA-74160

R-HSA-168256

R-HSA-1483257

R-HSA-392499

R-HSA-1483255

R-HSA-202403

R-HSA-9006925