R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995;
R-HSA-418594
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-198753;
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8878166;
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|