DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8939236)

Number of enzymes:	6
Number of disease:	10
Number of reactomes:	68
Number of reactions:	117

Search results (Reactome ID: R-HSA-8939236)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005453	ABL1	P00519	2.7.10.2	R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-428890 R-HSA-428890 Reactome Name: Role of ABL in ROBO-SLIT signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) DNA Repair Hemostasis Signal Transduction	R-HSA-1013833 ( R-HSA-983231 ) R-HSA-1013833 Reaction Name: Cables link CDK5 and ABL1 See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-376141 ( R-HSA-428890 ) R-HSA-376141 Reaction Name: Interaction of ABL with ROBO1:SLIT2 See in Reactome R-HSA-428883 ( R-HSA-428890 ) R-HSA-428883 Reaction Name: Recruitment of CAP to ABL See in Reactome R-HSA-428885 ( R-HSA-428890 ) R-HSA-428885 Reaction Name: Activation of CLASP See in Reactome R-HSA-428888 ( R-HSA-428890 ) R-HSA-428888 Reaction Name: Phosphorylation of ROBO1 by ABL kinase See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686587 ( R-HSA-5685938 ) R-HSA-5686587 Reaction Name: ABL1 phosphorylates RAD52 See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8956639 ( R-HSA-8939236 ) R-HSA-8956639 Reaction Name: RUNX1 binds YAP1 See in Reactome R-HSA-8956659 ( R-HSA-8939236 ) R-HSA-8956659 Reaction Name: ABL1 phosphorylates YAP1 See in Reactome R-HSA-8985227 ( R-HSA-8940973 ) R-HSA-8985227 Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter See in Reactome
MONDO:0009539	ABL1	P00519	2.7.10.2	R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-428890 R-HSA-428890 Reactome Name: Role of ABL in ROBO-SLIT signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) DNA Repair Hemostasis Signal Transduction	R-HSA-1013833 ( R-HSA-983231 ) R-HSA-1013833 Reaction Name: Cables link CDK5 and ABL1 See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-376141 ( R-HSA-428890 ) R-HSA-376141 Reaction Name: Interaction of ABL with ROBO1:SLIT2 See in Reactome R-HSA-428883 ( R-HSA-428890 ) R-HSA-428883 Reaction Name: Recruitment of CAP to ABL See in Reactome R-HSA-428885 ( R-HSA-428890 ) R-HSA-428885 Reaction Name: Activation of CLASP See in Reactome R-HSA-428888 ( R-HSA-428890 ) R-HSA-428888 Reaction Name: Phosphorylation of ROBO1 by ABL kinase See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686587 ( R-HSA-5685938 ) R-HSA-5686587 Reaction Name: ABL1 phosphorylates RAD52 See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8956639 ( R-HSA-8939236 ) R-HSA-8956639 Reaction Name: RUNX1 binds YAP1 See in Reactome R-HSA-8956659 ( R-HSA-8939236 ) R-HSA-8956659 Reaction Name: ABL1 phosphorylates YAP1 See in Reactome R-HSA-8985227 ( R-HSA-8940973 ) R-HSA-8985227 Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter See in Reactome
MONDO:0011518	KMT2A	Q03164	2.1.1.364 2.1.1.-	R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Chromatin organization Developmental Biology	R-HSA-5159245 ( R-HSA-3214841 ) R-HSA-5159245 Reaction Name: SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) See in Reactome R-HSA-5244692 ( R-HSA-3214841 ) R-HSA-5244692 Reaction Name: Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) See in Reactome R-HSA-5637686 ( R-HSA-3214841 ) R-HSA-5637686 Reaction Name: WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) See in Reactome R-HSA-8865482 ( R-HSA-8939236 ) R-HSA-8865482 Reaction Name: KMT2A (MLL) binds RUNX1 See in Reactome R-HSA-8865491 ( R-HSA-8939236 ) R-HSA-8865491 Reaction Name: RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene See in Reactome R-HSA-8865498 ( R-HSA-8939236 ) R-HSA-8865498 Reaction Name: KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark See in Reactome R-HSA-8865505 ( R-HSA-8939236; R-HSA-9616222 ) R-HSA-8865505 Reaction Name: SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome
MONDO:0011996	ABL1	P00519	2.7.10.2	R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-428890 R-HSA-428890 Reactome Name: Role of ABL in ROBO-SLIT signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) DNA Repair Hemostasis Signal Transduction	R-HSA-1013833 ( R-HSA-983231 ) R-HSA-1013833 Reaction Name: Cables link CDK5 and ABL1 See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-376141 ( R-HSA-428890 ) R-HSA-376141 Reaction Name: Interaction of ABL with ROBO1:SLIT2 See in Reactome R-HSA-428883 ( R-HSA-428890 ) R-HSA-428883 Reaction Name: Recruitment of CAP to ABL See in Reactome R-HSA-428885 ( R-HSA-428890 ) R-HSA-428885 Reaction Name: Activation of CLASP See in Reactome R-HSA-428888 ( R-HSA-428890 ) R-HSA-428888 Reaction Name: Phosphorylation of ROBO1 by ABL kinase See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686587 ( R-HSA-5685938 ) R-HSA-5686587 Reaction Name: ABL1 phosphorylates RAD52 See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8956639 ( R-HSA-8939236 ) R-HSA-8956639 Reaction Name: RUNX1 binds YAP1 See in Reactome R-HSA-8956659 ( R-HSA-8939236 ) R-HSA-8956659 Reaction Name: ABL1 phosphorylates YAP1 See in Reactome R-HSA-8985227 ( R-HSA-8940973 ) R-HSA-8985227 Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter See in Reactome
MONDO:0013245	ITCH	Q96J02	2.3.2.26	R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Signal Transduction	R-HSA-1253282 ( R-HSA-1253288 ) R-HSA-1253282 Reaction Name: ERBB4 ubiquitination by WWP1/ITCH See in Reactome R-HSA-1253300 ( R-HSA-1253288 ) R-HSA-1253300 Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases See in Reactome R-HSA-1912357 ( R-HSA-2122948 ) R-HSA-1912357 Reaction Name: ITCH ubiquitinates DTX See in Reactome R-HSA-1912386 ( R-HSA-2122948 ) R-HSA-1912386 Reaction Name: Ubiquitination of NOTCH1 by ITCH in the absence of ligand See in Reactome R-HSA-1980125 ( R-HSA-2122948 ) R-HSA-1980125 Reaction Name: ITCH binds DTX See in Reactome R-HSA-1980128 ( R-HSA-2122948 ) R-HSA-1980128 Reaction Name: NOTCH1 associates with negative regulators NUMB and ITCH See in Reactome R-HSA-5610735 ( R-HSA-5610780; R-HSA-5632684 ) R-HSA-5610735 Reaction Name: NUMB binds ITCH See in Reactome R-HSA-5610737 ( R-HSA-5610780 ) R-HSA-5610737 Reaction Name: NUMB:ITCH bind and ubiquitnate GLI1 See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635861 ( R-HSA-5632684 ) R-HSA-5635861 Reaction Name: NUMB:ITCH binds GLI1 See in Reactome R-HSA-5635864 ( R-HSA-5632684 ) R-HSA-5635864 Reaction Name: NUMB:ITCH ubiquitinates GLI1 See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-688137 ( R-HSA-168638 ) R-HSA-688137 Reaction Name: RIP2 is K63 polyubiquitinated See in Reactome R-HSA-8956652 ( R-HSA-8939236 ) R-HSA-8956652 Reaction Name: ITCH gene expression is stimulated by RUNX1 and YAP1 See in Reactome R-HSA-8956684 ( R-HSA-8939236 ) R-HSA-8956684 Reaction Name: ITCH polyubiquitinates TP73 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome R-HSA-990526 ( R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome
MONDO:0023644	ABL1	P00519	2.7.10.2	R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-428890 R-HSA-428890 Reactome Name: Role of ABL in ROBO-SLIT signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) DNA Repair Hemostasis Signal Transduction	R-HSA-1013833 ( R-HSA-983231 ) R-HSA-1013833 Reaction Name: Cables link CDK5 and ABL1 See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-376141 ( R-HSA-428890 ) R-HSA-376141 Reaction Name: Interaction of ABL with ROBO1:SLIT2 See in Reactome R-HSA-428883 ( R-HSA-428890 ) R-HSA-428883 Reaction Name: Recruitment of CAP to ABL See in Reactome R-HSA-428885 ( R-HSA-428890 ) R-HSA-428885 Reaction Name: Activation of CLASP See in Reactome R-HSA-428888 ( R-HSA-428890 ) R-HSA-428888 Reaction Name: Phosphorylation of ROBO1 by ABL kinase See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686587 ( R-HSA-5685938 ) R-HSA-5686587 Reaction Name: ABL1 phosphorylates RAD52 See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8956639 ( R-HSA-8939236 ) R-HSA-8956639 Reaction Name: RUNX1 binds YAP1 See in Reactome R-HSA-8956659 ( R-HSA-8939236 ) R-HSA-8956659 Reaction Name: ABL1 phosphorylates YAP1 See in Reactome R-HSA-8985227 ( R-HSA-8940973 ) R-HSA-8985227 Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter See in Reactome
MONDO:0030924	PSMB10	P40306	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0054698	PSMB8	P28062	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0054699	PSMB9	P28065	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0060532	ABL1	P00519	2.7.10.2	R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-428890 R-HSA-428890 Reactome Name: Role of ABL in ROBO-SLIT signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) DNA Repair Hemostasis Signal Transduction	R-HSA-1013833 ( R-HSA-983231 ) R-HSA-1013833 Reaction Name: Cables link CDK5 and ABL1 See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-376141 ( R-HSA-428890 ) R-HSA-376141 Reaction Name: Interaction of ABL with ROBO1:SLIT2 See in Reactome R-HSA-428883 ( R-HSA-428890 ) R-HSA-428883 Reaction Name: Recruitment of CAP to ABL See in Reactome R-HSA-428885 ( R-HSA-428890 ) R-HSA-428885 Reaction Name: Activation of CLASP See in Reactome R-HSA-428888 ( R-HSA-428890 ) R-HSA-428888 Reaction Name: Phosphorylation of ROBO1 by ABL kinase See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686587 ( R-HSA-5685938 ) R-HSA-5686587 Reaction Name: ABL1 phosphorylates RAD52 See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8956639 ( R-HSA-8939236 ) R-HSA-8956639 Reaction Name: RUNX1 binds YAP1 See in Reactome R-HSA-8956659 ( R-HSA-8939236 ) R-HSA-8956659 Reaction Name: ABL1 phosphorylates YAP1 See in Reactome R-HSA-8985227 ( R-HSA-8940973 ) R-HSA-8985227 Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter See in Reactome