DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8878166)

Number of enzymes:	3
Number of disease:	10
Number of reactomes:	20
Number of reactions:	54

Search results (Reactome ID: R-HSA-8878166)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005012	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0005061	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0008170	PPM1D	O15297	3.1.3.16	R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription)	R-HSA-9008822 ( R-HSA-8878166 ) R-HSA-9008822 Reaction Name: PPM1D dephosphorylates RUNX2 See in Reactome
MONDO:0009693	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0010463	HDAC6	Q9UBN7	3.5.1.98 3.5.1.-	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9613829 R-HSA-9613829 Reactome Name: Chaperone Mediated Autophagy See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-9615710 R-HSA-9615710 Reactome Name: Late endosomal microautophagy See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Organelle biogenesis and maintenance Cellular responses to stimuli Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5618331 ( R-HSA-5617833 ) R-HSA-5618331 Reaction Name: HDAC6 deacetylates microtubules See in Reactome R-HSA-9008389 ( R-HSA-8878166; R-HSA-8940973 ) R-HSA-9008389 Reaction Name: RUNX2 binds HDAC6 See in Reactome R-HSA-9008433 ( R-HSA-8878166 ) R-HSA-9008433 Reaction Name: RUNX2 binds CDKN1A gene promoter See in Reactome R-HSA-9008456 ( R-HSA-8878166 ) R-HSA-9008456 Reaction Name: CDKN1A gene expression is inhibited by RUNX2 See in Reactome R-HSA-9615721 ( R-HSA-9613829; R-HSA-9615710 ) R-HSA-9615721 Reaction Name: HSPA8 binds substrate See in Reactome R-HSA-9620197 ( R-HSA-9613829 ) R-HSA-9620197 Reaction Name: HSPA8:Substrate binds LAMP2a See in Reactome R-HSA-9622831 ( R-HSA-9613829 ) R-HSA-9622831 Reaction Name: Substrate:LAMP2a binds HSP90 See in Reactome R-HSA-9622840 ( R-HSA-9613829 ) R-HSA-9622840 Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate See in Reactome R-HSA-9624158 ( R-HSA-9613829 ) R-HSA-9624158 Reaction Name: Substrate:LAMP2a:HSP90 polymerizes See in Reactome R-HSA-9625188 ( R-HSA-9613829 ) R-HSA-9625188 Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation See in Reactome R-HSA-9625196 ( R-HSA-9613829 ) R-HSA-9625196 Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8 See in Reactome R-HSA-9625197 ( R-HSA-9613829 ) R-HSA-9625197 Reaction Name: GFAP binds LAMP2a multimer See in Reactome R-HSA-9626060 ( R-HSA-9613829 ) R-HSA-9626060 Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer See in Reactome R-HSA-9631065 ( R-HSA-9615710 ) R-HSA-9631065 Reaction Name: Substrate translocates into late endosomal lumen See in Reactome R-HSA-9631068 ( R-HSA-9615710 ) R-HSA-9631068 Reaction Name: HSPA8:substrate binds late endosomal phospholipids See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646348 ( R-HSA-9646399 ) R-HSA-9646348 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9646383 ( R-HSA-9646399 ) R-HSA-9646383 Reaction Name: Dynein motors transport misfolded proteins See in Reactome R-HSA-9646390 ( R-HSA-9646399 ) R-HSA-9646390 Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule See in Reactome R-HSA-9646679 ( R-HSA-9646399 ) R-HSA-9646679 Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome See in Reactome R-HSA-9646685 ( R-HSA-9646399 ) R-HSA-9646685 Reaction Name: Aggresome dissociates from dynein and microtubule See in Reactome
MONDO:0012183	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0015356	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0016419	PPM1D	O15297	3.1.3.16	R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription)	R-HSA-9008822 ( R-HSA-8878166 ) R-HSA-9008822 Reaction Name: PPM1D dephosphorylates RUNX2 See in Reactome
MONDO:0019438	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0044318	PPM1D	O15297	3.1.3.16	R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription)	R-HSA-9008822 ( R-HSA-8878166 ) R-HSA-9008822 Reaction Name: PPM1D dephosphorylates RUNX2 See in Reactome