DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8874211)

Number of enzymes:	2
Number of disease:	7
Number of reactomes:	6
Number of reactions:	16

Search results (Reactome ID: R-HSA-8874211)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010486	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0010637	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0019414	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0032721	MBTPS1	Q14703	3.4.21.112	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Cellular responses to stimuli Metabolism of proteins Metabolism Transport of small molecules	R-HSA-1655842 ( R-HSA-1655829 ) R-HSA-1655842 Reaction Name: S1P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-381135 ( R-HSA-381033 ) R-HSA-381135 Reaction Name: MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874186 ( R-HSA-8874211 ) R-HSA-8874186 Reaction Name: MBTPS1 (S1P) cleaves CREB3L4 See in Reactome R-HSA-8874204 ( R-HSA-8874211 ) R-HSA-8874204 Reaction Name: MBTPS1 (S1P) cleaves CREB3 See in Reactome R-HSA-8874205 ( R-HSA-8874211 ) R-HSA-8874205 Reaction Name: MBTPS1 (S1P) cleaves CREB3L2 See in Reactome R-HSA-8874206 ( R-HSA-8874211 ) R-HSA-8874206 Reaction Name: MBTPS1 (S1P) cleaves CREB3L3 See in Reactome R-HSA-8874212 ( R-HSA-8874211 ) R-HSA-8874212 Reaction Name: MBTPS1 (S1P) cleaves CREB3L1 See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0049223	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0100213	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome
MONDO:0100296	MBTPS2	O43462	3.4.24.85	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Transport of small molecules Metabolism Cellular responses to stimuli	R-HSA-1655851 ( R-HSA-1655829 ) R-HSA-1655851 Reaction Name: S2P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-420818 ( R-HSA-381033 ) R-HSA-420818 Reaction Name: MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874187 ( R-HSA-8874211 ) R-HSA-8874187 Reaction Name: MBTPS2 (S2P) cleaves CREB3L2 See in Reactome R-HSA-8874192 ( R-HSA-8874211 ) R-HSA-8874192 Reaction Name: MBTPS2 (S2P) cleaves CREB3 See in Reactome R-HSA-8874194 ( R-HSA-8874211 ) R-HSA-8874194 Reaction Name: MBTPS2 (S2P) cleaves CREB3L1 See in Reactome R-HSA-8874195 ( R-HSA-8874211 ) R-HSA-8874195 Reaction Name: MBTPS2 (S2P) cleaves CREB3L4 See in Reactome R-HSA-8874201 ( R-HSA-8874211 ) R-HSA-8874201 Reaction Name: MBTPS2 (S2P) cleaves CREB3L3 See in Reactome