DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8874081)

Number of enzymes:	2
Number of disease:	11
Number of reactomes:	68
Number of reactions:	125

Search results (Reactome ID: R-HSA-8874081)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0003789	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0005138	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0005298	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0005575	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0009692	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0011806	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0014739	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0014837	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome
MONDO:0015356	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0018055	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0044903	SRC	P12931	2.7.10.2	R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-428542 R-HSA-428542 Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-430116 R-HSA-430116 Reactome Name: GP1b-IX-V activation signalling See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-372708 R-HSA-372708 Reactome Name: p130Cas linkage to MAPK signaling for integrins See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-354194 R-HSA-354194 Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-191650 R-HSA-191650 Reactome Name: Regulation of gap junction activity See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Cell Cycle Developmental Biology Autophagy Gene expression (Transcription) Neuronal System Signal Transduction Vesicle-mediated transport Hemostasis	R-HSA-1252013 ( R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-186819 ( R-HSA-186763 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-354066 ( R-HSA-354192 ) R-HSA-354066 Reaction Name: Translocation of PTK2 to Focal complexes See in Reactome R-HSA-354073 ( R-HSA-354192 ) R-HSA-354073 Reaction Name: Autophosphorylation of PTK2 at Y397 See in Reactome R-HSA-354077 ( R-HSA-354192 ) R-HSA-354077 Reaction Name: Integrin alphaIIb beta3 activation See in Reactome R-HSA-354087 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354087 Reaction Name: Recruitment of GRB2 to p-PTK2 See in Reactome R-HSA-354124 ( R-HSA-354192 ) R-HSA-354124 Reaction Name: Phosphorylation of pPTK2 by SRC See in Reactome R-HSA-354149 ( R-HSA-354192 ) R-HSA-354149 Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen See in Reactome R-HSA-354165 ( R-HSA-354192; R-HSA-354194 ) R-HSA-354165 Reaction Name: Interaction of SOS with GRB2 bound to FADK1 See in Reactome R-HSA-372693 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372693 Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex See in Reactome R-HSA-372697 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372697 Reaction Name: Crk binding to p130cas See in Reactome R-HSA-372705 ( R-HSA-354192; R-HSA-372708 ) R-HSA-372705 Reaction Name: Recruitment of BCAR1 to PTK2 complex See in Reactome R-HSA-373716 ( R-HSA-418885 ) R-HSA-373716 Reaction Name: DCC interacting NCK-1 See in Reactome R-HSA-374701 ( R-HSA-418885 ) R-HSA-374701 Reaction Name: Phosphorylation of DCC by Fyn See in Reactome R-HSA-377640 ( R-HSA-354192 ) R-HSA-377640 Reaction Name: Autophosphorylation of SRC See in Reactome R-HSA-377641 ( R-HSA-354192 ) R-HSA-377641 Reaction Name: Clustering of Integrin alphaIIb beta3 complexes See in Reactome R-HSA-377643 ( R-HSA-354192 ) R-HSA-377643 Reaction Name: Dephosphorylation of inactive SRC by PTPB1 See in Reactome R-HSA-377644 ( R-HSA-354192 ) R-HSA-377644 Reaction Name: Release of CSK from SRC See in Reactome R-HSA-380780 ( R-HSA-186763 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-418850 ( R-HSA-418885 ) R-HSA-418850 Reaction Name: Activation of Cdc42 See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418858 ( R-HSA-418885 ) R-HSA-418858 Reaction Name: RhoGTPase GEF's recruited to DCC See in Reactome R-HSA-418859 ( R-HSA-418886 ) R-HSA-418859 Reaction Name: Phosphorylation of Unc5C See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-418868 ( R-HSA-418885 ) R-HSA-418868 Reaction Name: Recruitment of Src and Fyn to DCC:FADK1 See in Reactome R-HSA-418874 ( R-HSA-418885 ) R-HSA-418874 Reaction Name: Recruitment and activation of N-WASP by Cdc42 See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-432096 ( R-HSA-354192 ) R-HSA-432096 Reaction Name: Activated integrin alphaIIb beta3 binds SHC1 See in Reactome R-HSA-443905 ( R-HSA-354192 ) R-HSA-443905 Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow See in Reactome R-HSA-443910 ( R-HSA-354192 ) R-HSA-443910 Reaction Name: SHC1 dissociates from integrin alphaIIb beta3 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8937682 ( R-HSA-8934593 ) R-HSA-8937682 Reaction Name: RUNX1 binds SRC See in Reactome R-HSA-8937728 ( R-HSA-8934593 ) R-HSA-8937728 Reaction Name: SRC phosphorylates RUNX1 See in Reactome R-HSA-8937792 ( R-HSA-8941858 ) R-HSA-8937792 Reaction Name: RUNX3 binds SRC See in Reactome R-HSA-8937807 ( R-HSA-8941858 ) R-HSA-8937807 Reaction Name: SRC phosphorylates RUNX3 See in Reactome R-HSA-8937814 ( R-HSA-8941858 ) R-HSA-8937814 Reaction Name: RUNX3 translocates to the nucleus See in Reactome R-HSA-8937820 ( R-HSA-8940973 ) R-HSA-8937820 Reaction Name: SRC,YES1 bind YAP1 See in Reactome R-HSA-8937844 ( R-HSA-8940973 ) R-HSA-8937844 Reaction Name: SRC,YES1 phosphorylate YAP1 See in Reactome R-HSA-8964242 ( R-HSA-418594 ) R-HSA-8964242 Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964252 ( R-HSA-418555 ) R-HSA-8964252 Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC See in Reactome R-HSA-8964278 ( R-HSA-418555 ) R-HSA-8964278 Reaction Name: G protein alpha (s):GTP binds SRC See in Reactome R-HSA-8964287 ( R-HSA-418555 ) R-HSA-8964287 Reaction Name: G alpha (s):GTP:SRC dissociates See in Reactome R-HSA-8964311 ( R-HSA-418594 ) R-HSA-8964311 Reaction Name: G alpha (i):GTP binds SRC See in Reactome R-HSA-8964329 ( R-HSA-418594 ) R-HSA-8964329 Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC See in Reactome R-HSA-9011241 ( R-HSA-428542 ) R-HSA-9011241 Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1 See in Reactome R-HSA-9021596 ( R-HSA-9009391 ) R-HSA-9021596 Reaction Name: Membrane estrogen receptors bind SRC See in Reactome R-HSA-9021609 ( R-HSA-9009391 ) R-HSA-9021609 Reaction Name: ESR-associated SRC autophosphorylates See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9603419 ( R-HSA-9603381 ) R-HSA-9603419 Reaction Name: Activated NTRK3 binds SRC See in Reactome R-HSA-9603420 ( R-HSA-9603381 ) R-HSA-9603420 Reaction Name: Activated NTRK3 promotes SRC autophosphorylation See in Reactome R-HSA-9603437 ( R-HSA-9603381 ) R-HSA-9603437 Reaction Name: Activated NTRK3 binds IRS1 See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9624014 ( R-HSA-418555 ) R-HSA-9624014 Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9726848 ( R-HSA-9013420 ) R-HSA-9726848 Reaction Name: SRC phosphorylates RHOU See in Reactome