DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8866652)

Number of enzymes:	6
Number of disease:	9
Number of reactomes:	17
Number of reactions:	52

Search results (Reactome ID: R-HSA-8866652)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010461	UBE2A	P49459	2.3.2.23	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System Metabolism of proteins	R-HSA-8852130 ( R-HSA-8866652 ) R-HSA-8852130 Reaction Name: UBA1 conjugates ubiquitin to nuclear E2 enzymes See in Reactome R-HSA-8942099 ( R-HSA-8866654 ) R-HSA-8942099 Reaction Name: RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B See in Reactome R-HSA-8942101 ( R-HSA-8866654 ) R-HSA-8942101 Reaction Name: RNF20:RNF40 monoubiquitinates Histone H2B See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983152 ( R-HSA-983168 ) R-HSA-983152 Reaction Name: Transfer of ubiquitin from E1 to E2 See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0010487	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0010502	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0010532	UBA1	P22314	6.2.1.45	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System Metabolism of proteins	R-HSA-8852128 ( R-HSA-8866652 ) R-HSA-8852128 Reaction Name: UBA1 adenylates ubiquitin in the nucleoplasm See in Reactome R-HSA-8852129 ( R-HSA-8866652 ) R-HSA-8852129 Reaction Name: UBA1 conjugates ubiquitin to cytosolic E2 enzymes See in Reactome R-HSA-8852130 ( R-HSA-8866652 ) R-HSA-8852130 Reaction Name: UBA1 conjugates ubiquitin to nuclear E2 enzymes See in Reactome R-HSA-8852131 ( R-HSA-8866652 ) R-HSA-8852131 Reaction Name: Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus See in Reactome R-HSA-8852132 ( R-HSA-8866652 ) R-HSA-8852132 Reaction Name: Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol See in Reactome R-HSA-8852133 ( R-HSA-8866652 ) R-HSA-8852133 Reaction Name: UBA1 conjugates ubiquitin to UBA1 in the cytosol See in Reactome R-HSA-8852134 ( R-HSA-8866652 ) R-HSA-8852134 Reaction Name: UBA1 adenylates ubiquitin in the cytosol See in Reactome R-HSA-8852136 ( R-HSA-8866652 ) R-HSA-8852136 Reaction Name: UBA1 conjugates ubiquitin to UBA1 in the nucleus See in Reactome R-HSA-983152 ( R-HSA-983168 ) R-HSA-983152 Reaction Name: Transfer of ubiquitin from E1 to E2 See in Reactome R-HSA-983153 ( R-HSA-983168 ) R-HSA-983153 Reaction Name: E1 mediated ubiquitin activation See in Reactome
MONDO:0014638	UBE2T	Q9NPD8	2.3.2.23	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	DNA Repair Metabolism of proteins	R-HSA-6785342 ( R-HSA-6783310 ) R-HSA-6785342 Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex See in Reactome R-HSA-6785361 ( R-HSA-6783310 ) R-HSA-6785361 Reaction Name: Monoubiquitination of FANCD2:FANCI See in Reactome R-HSA-6788385 ( R-HSA-6783310 ) R-HSA-6788385 Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA See in Reactome R-HSA-6788392 ( R-HSA-6783310 ) R-HSA-6788392 Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA See in Reactome R-HSA-8852130 ( R-HSA-8866652 ) R-HSA-8852130 Reaction Name: UBA1 conjugates ubiquitin to nuclear E2 enzymes See in Reactome
MONDO:0014805	USP7	Q93009	3.4.19.12	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins DNA Repair Signal Transduction	R-HSA-3215295 ( R-HSA-6804757 ) R-HSA-3215295 Reaction Name: USP7 deubiquitinates MDM2 See in Reactome R-HSA-3215310 ( R-HSA-6804757 ) R-HSA-3215310 Reaction Name: USP7 deubiquitinates TP53 and counteracts MDM2 See in Reactome R-HSA-3222072 ( R-HSA-6804757 ) R-HSA-3222072 Reaction Name: DAXX binds Ub-MDM2 and USP7 See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0014912	OTULIN	Q96BN8	3.4.19.12	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-8853515 ( R-HSA-8866652 ) R-HSA-8853515 Reaction Name: OTULIN,USP5 cleaves UBC yielding ubiquitin See in Reactome R-HSA-8853529 ( R-HSA-8866652 ) R-HSA-8853529 Reaction Name: OTULIN,USP5 cleaves UBB yielding ubiquitin See in Reactome
MONDO:0018821	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0026777	UBA1	P22314	6.2.1.45	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System Metabolism of proteins	R-HSA-8852128 ( R-HSA-8866652 ) R-HSA-8852128 Reaction Name: UBA1 adenylates ubiquitin in the nucleoplasm See in Reactome R-HSA-8852129 ( R-HSA-8866652 ) R-HSA-8852129 Reaction Name: UBA1 conjugates ubiquitin to cytosolic E2 enzymes See in Reactome R-HSA-8852130 ( R-HSA-8866652 ) R-HSA-8852130 Reaction Name: UBA1 conjugates ubiquitin to nuclear E2 enzymes See in Reactome R-HSA-8852131 ( R-HSA-8866652 ) R-HSA-8852131 Reaction Name: Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus See in Reactome R-HSA-8852132 ( R-HSA-8866652 ) R-HSA-8852132 Reaction Name: Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol See in Reactome R-HSA-8852133 ( R-HSA-8866652 ) R-HSA-8852133 Reaction Name: UBA1 conjugates ubiquitin to UBA1 in the cytosol See in Reactome R-HSA-8852134 ( R-HSA-8866652 ) R-HSA-8852134 Reaction Name: UBA1 adenylates ubiquitin in the cytosol See in Reactome R-HSA-8852136 ( R-HSA-8866652 ) R-HSA-8852136 Reaction Name: UBA1 conjugates ubiquitin to UBA1 in the nucleus See in Reactome R-HSA-983152 ( R-HSA-983168 ) R-HSA-983152 Reaction Name: Transfer of ubiquitin from E1 to E2 See in Reactome R-HSA-983153 ( R-HSA-983168 ) R-HSA-983153 Reaction Name: E1 mediated ubiquitin activation See in Reactome