DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8854518)

Number of enzymes:	5
Number of disease:	9
Number of reactomes:	43
Number of reactions:	76

Search results (Reactome ID: R-HSA-8854518)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009624	PLK4	O00444	2.7.11.21	R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome	R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome	Cell Cycle Organelle biogenesis and maintenance	R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome
MONDO:0009693	AURKA	O14965	2.7.11.1	R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8854521 R-HSA-8854521 Reactome Name: Interaction between PHLDA1 and AURKA See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins Cell Cycle	R-HSA-174088 ( R-HSA-174178 ) R-HSA-174088 Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174195 ( R-HSA-174178 ) R-HSA-174195 Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-4655404 ( R-HSA-4615885 ) R-HSA-4655404 Reaction Name: SUMOylation of AURKA with SUMO1 See in Reactome R-HSA-6791235 ( R-HSA-6804114 ) R-HSA-6791235 Reaction Name: GADD45A binds AURKA See in Reactome R-HSA-6805103 ( R-HSA-6804756 ) R-HSA-6805103 Reaction Name: AURKA phosphorylates TP53 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8853429 ( R-HSA-8854521 ) R-HSA-8853429 Reaction Name: PHLDA1 binds AURKA See in Reactome R-HSA-8853444 ( R-HSA-8854521 ) R-HSA-8853444 Reaction Name: AURKA phosphorylates PHLDA1 See in Reactome R-HSA-8853496 ( R-HSA-8854050 ) R-HSA-8853496 Reaction Name: SCF:FBXL7 binds AURKA See in Reactome R-HSA-8854041 ( R-HSA-8854050 ) R-HSA-8854041 Reaction Name: SCF-FBXL7 ubiquitinates AURKA See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome
MONDO:0014088	CSNK1D	P48730	2.7.11.26 2.7.11.1	R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-204005 R-HSA-204005 Reactome Name: COPII-mediated vesicle transport See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome	R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome R-HSA-199977 R-HSA-199977 Reactome Name: ER to Golgi Anterograde Transport See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-948021 R-HSA-948021 Reactome Name: Transport to the Golgi and subsequent modification See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Circadian Clock Organelle biogenesis and maintenance Metabolism of RNA Metabolism of proteins Cell Cycle Vesicle-mediated transport	R-HSA-1856948 ( R-HSA-400253 ) R-HSA-1856948 Reaction Name: Formation of CRY:PER:Kinase complex See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-400256 ( R-HSA-400253 ) R-HSA-400256 Reaction Name: CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-549385 ( R-HSA-400253 ) R-HSA-549385 Reaction Name: CRY:PER:Kinase complex translocates to the nucleus See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-5694441 ( R-HSA-204005 ) R-HSA-5694441 Reaction Name: CSNK1D phosphorylates SEC23 See in Reactome R-HSA-6791223 ( R-HSA-6791226 ) R-HSA-6791223 Reaction Name: 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome
MONDO:0014256	NEK2	P51955	2.7.11.1	R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-179409 R-HSA-179409 Reactome Name: APC-Cdc20 mediated degradation of Nek2A See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome	Organelle biogenesis and maintenance Cell Cycle	R-HSA-179410 ( R-HSA-179409 ) R-HSA-179410 Reaction Name: Association of Nek2A with MCC:APC/C See in Reactome R-HSA-179417 ( R-HSA-179409 ) R-HSA-179417 Reaction Name: Multiubiquitination of Nek2A See in Reactome R-HSA-179421 ( R-HSA-179409 ) R-HSA-179421 Reaction Name: Degradation of multiubiquitinated Nek2A See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome
MONDO:0014359	PRKACA	P17612	2.7.11.11	R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9010642 R-HSA-9010642 Reactome Name: ROBO receptors bind AKAP5 See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome R-HSA-163358 R-HSA-163358 Reactome Name: PKA-mediated phosphorylation of key metabolic factors See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Organelle biogenesis and maintenance Neuronal System Hemostasis Signal Transduction	R-HSA-111919 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111919 Reaction Name: PKA phosphorylates CREB1 See in Reactome R-HSA-111924 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111924 Reaction Name: PKA catalytic subunit translocates to the nucleus See in Reactome R-HSA-111925 ( R-HSA-111931; R-HSA-163615; R-HSA-164378; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-111925 Reaction Name: cAMP induces dissociation of inactive PKA tetramers See in Reactome R-HSA-163416 ( R-HSA-163560 ) R-HSA-163416 Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP See in Reactome R-HSA-163418 ( R-HSA-163560 ) R-HSA-163418 Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP See in Reactome R-HSA-163672 ( R-HSA-163358 ) R-HSA-163672 Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA See in Reactome R-HSA-163676 ( R-HSA-163358 ) R-HSA-163676 Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA See in Reactome R-HSA-163773 ( R-HSA-163358; R-HSA-9634600 ) R-HSA-163773 Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit See in Reactome R-HSA-177275 ( R-HSA-180024 ) R-HSA-177275 Reaction Name: PKA phosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-177284 ( R-HSA-180024 ) R-HSA-177284 Reaction Name: PKA phosphorylates PDE4B See in Reactome R-HSA-180073 ( R-HSA-180024 ) R-HSA-180073 Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-265682 ( R-HSA-422356 ) R-HSA-265682 Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-381644 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381644 Reaction Name: ER calcium channels open in response to activated PKA See in Reactome R-HSA-381707 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381707 Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP See in Reactome R-HSA-381713 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381713 Reaction Name: Potassium voltage-gated channels close in reponse to PKA See in Reactome R-HSA-432232 ( R-HSA-432040 ) R-HSA-432232 Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5610717 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610717 Reaction Name: PKA phosphorylates GLI2 See in Reactome R-HSA-5610720 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610720 Reaction Name: PKA phosphorylates GLI3 See in Reactome R-HSA-5610741 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610741 Reaction Name: PKA phosphorylates GLI1 See in Reactome R-HSA-5610749 ( R-HSA-5610787 ) R-HSA-5610749 Reaction Name: cAMP dissociates PKA, promoting GLI processing See in Reactome R-HSA-5617179 ( R-HSA-5578775 ) R-HSA-5617179 Reaction Name: PRKACA phosphorylates TNNI3 See in Reactome R-HSA-5617182 ( R-HSA-5578775 ) R-HSA-5617182 Reaction Name: PRKACA phosphorylates PLN See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5624473 ( R-HSA-5621575 ) R-HSA-5624473 Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-5682101 ( R-HSA-8963896 ) R-HSA-5682101 Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer See in Reactome R-HSA-5687088 ( R-HSA-5687128 ) R-HSA-5687088 Reaction Name: PKA phosphorylates MAPKAPK5 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8951727 ( R-HSA-111931; R-HSA-163615; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-8951727 Reaction Name: cAMP binds PKA tetramer See in Reactome R-HSA-8986937 ( R-HSA-9022692 ) R-HSA-8986937 Reaction Name: MECP2 is phosphorylated at T308 See in Reactome R-HSA-8986939 ( R-HSA-9022692 ) R-HSA-8986939 Reaction Name: MECP2 binds the NCoR/SMRT complex See in Reactome R-HSA-9010641 ( R-HSA-9010642 ) R-HSA-9010641 Reaction Name: AKAP5 recruits PKA to ROBO2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-913996 ( R-HSA-392517 ) R-HSA-913996 Reaction Name: PKA/PKG phosphorylate Rap1GAP2 See in Reactome R-HSA-992708 ( R-HSA-983231 ) R-HSA-992708 Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits See in Reactome
MONDO:0014516	PLK4	O00444	2.7.11.21	R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome	R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome	Cell Cycle Organelle biogenesis and maintenance	R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome
MONDO:0019342	PLK4	O00444	2.7.11.21	R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome	R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome	Cell Cycle Organelle biogenesis and maintenance	R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome
MONDO:0019438	AURKA	O14965	2.7.11.1	R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8854521 R-HSA-8854521 Reactome Name: Interaction between PHLDA1 and AURKA See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins Cell Cycle	R-HSA-174088 ( R-HSA-174178 ) R-HSA-174088 Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174195 ( R-HSA-174178 ) R-HSA-174195 Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-4655404 ( R-HSA-4615885 ) R-HSA-4655404 Reaction Name: SUMOylation of AURKA with SUMO1 See in Reactome R-HSA-6791235 ( R-HSA-6804114 ) R-HSA-6791235 Reaction Name: GADD45A binds AURKA See in Reactome R-HSA-6805103 ( R-HSA-6804756 ) R-HSA-6805103 Reaction Name: AURKA phosphorylates TP53 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8853429 ( R-HSA-8854521 ) R-HSA-8853429 Reaction Name: PHLDA1 binds AURKA See in Reactome R-HSA-8853444 ( R-HSA-8854521 ) R-HSA-8853444 Reaction Name: AURKA phosphorylates PHLDA1 See in Reactome R-HSA-8853496 ( R-HSA-8854050 ) R-HSA-8853496 Reaction Name: SCF:FBXL7 binds AURKA See in Reactome R-HSA-8854041 ( R-HSA-8854050 ) R-HSA-8854041 Reaction Name: SCF-FBXL7 ubiquitinates AURKA See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome
MONDO:0030876	PRKACA	P17612	2.7.11.11	R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9010642 R-HSA-9010642 Reactome Name: ROBO receptors bind AKAP5 See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome R-HSA-163358 R-HSA-163358 Reactome Name: PKA-mediated phosphorylation of key metabolic factors See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Organelle biogenesis and maintenance Neuronal System Hemostasis Signal Transduction	R-HSA-111919 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111919 Reaction Name: PKA phosphorylates CREB1 See in Reactome R-HSA-111924 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111924 Reaction Name: PKA catalytic subunit translocates to the nucleus See in Reactome R-HSA-111925 ( R-HSA-111931; R-HSA-163615; R-HSA-164378; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-111925 Reaction Name: cAMP induces dissociation of inactive PKA tetramers See in Reactome R-HSA-163416 ( R-HSA-163560 ) R-HSA-163416 Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP See in Reactome R-HSA-163418 ( R-HSA-163560 ) R-HSA-163418 Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP See in Reactome R-HSA-163672 ( R-HSA-163358 ) R-HSA-163672 Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA See in Reactome R-HSA-163676 ( R-HSA-163358 ) R-HSA-163676 Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA See in Reactome R-HSA-163773 ( R-HSA-163358; R-HSA-9634600 ) R-HSA-163773 Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit See in Reactome R-HSA-177275 ( R-HSA-180024 ) R-HSA-177275 Reaction Name: PKA phosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-177284 ( R-HSA-180024 ) R-HSA-177284 Reaction Name: PKA phosphorylates PDE4B See in Reactome R-HSA-180073 ( R-HSA-180024 ) R-HSA-180073 Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-265682 ( R-HSA-422356 ) R-HSA-265682 Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-381644 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381644 Reaction Name: ER calcium channels open in response to activated PKA See in Reactome R-HSA-381707 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381707 Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP See in Reactome R-HSA-381713 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381713 Reaction Name: Potassium voltage-gated channels close in reponse to PKA See in Reactome R-HSA-432232 ( R-HSA-432040 ) R-HSA-432232 Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5610717 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610717 Reaction Name: PKA phosphorylates GLI2 See in Reactome R-HSA-5610720 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610720 Reaction Name: PKA phosphorylates GLI3 See in Reactome R-HSA-5610741 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610741 Reaction Name: PKA phosphorylates GLI1 See in Reactome R-HSA-5610749 ( R-HSA-5610787 ) R-HSA-5610749 Reaction Name: cAMP dissociates PKA, promoting GLI processing See in Reactome R-HSA-5617179 ( R-HSA-5578775 ) R-HSA-5617179 Reaction Name: PRKACA phosphorylates TNNI3 See in Reactome R-HSA-5617182 ( R-HSA-5578775 ) R-HSA-5617182 Reaction Name: PRKACA phosphorylates PLN See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5624473 ( R-HSA-5621575 ) R-HSA-5624473 Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-5682101 ( R-HSA-8963896 ) R-HSA-5682101 Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer See in Reactome R-HSA-5687088 ( R-HSA-5687128 ) R-HSA-5687088 Reaction Name: PKA phosphorylates MAPKAPK5 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8951727 ( R-HSA-111931; R-HSA-163615; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-8951727 Reaction Name: cAMP binds PKA tetramer See in Reactome R-HSA-8986937 ( R-HSA-9022692 ) R-HSA-8986937 Reaction Name: MECP2 is phosphorylated at T308 See in Reactome R-HSA-8986939 ( R-HSA-9022692 ) R-HSA-8986939 Reaction Name: MECP2 binds the NCoR/SMRT complex See in Reactome R-HSA-9010641 ( R-HSA-9010642 ) R-HSA-9010641 Reaction Name: AKAP5 recruits PKA to ROBO2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-913996 ( R-HSA-392517 ) R-HSA-913996 Reaction Name: PKA/PKG phosphorylate Rap1GAP2 See in Reactome R-HSA-992708 ( R-HSA-983231 ) R-HSA-992708 Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits See in Reactome