DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-8853884)

Number of enzymes:	2
Number of disease:	6
Number of reactomes:	6
Number of reactions:	17

Search results (Reactome ID: R-HSA-8853884)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007088	CSF1R	P07333	2.7.10.1	R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System	R-HSA-6787820 ( R-HSA-449836 ) R-HSA-6787820 Reaction Name: IL34 dimer binds CSF1R See in Reactome R-HSA-8853908 ( R-HSA-8853884 ) R-HSA-8853908 Reaction Name: VENTX stimulates CSF1R (M-CSF-R) expression See in Reactome R-HSA-9009485 ( R-HSA-449836 ) R-HSA-9009485 Reaction Name: IL34:CSF1 binds CSF1R See in Reactome R-HSA-9009554 ( R-HSA-449836 ) R-HSA-9009554 Reaction Name: IL34 dimer:SDC1 binds CSF1R See in Reactome
MONDO:0009096	CSF1R	P07333	2.7.10.1	R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System	R-HSA-6787820 ( R-HSA-449836 ) R-HSA-6787820 Reaction Name: IL34 dimer binds CSF1R See in Reactome R-HSA-8853908 ( R-HSA-8853884 ) R-HSA-8853908 Reaction Name: VENTX stimulates CSF1R (M-CSF-R) expression See in Reactome R-HSA-9009485 ( R-HSA-449836 ) R-HSA-9009485 Reaction Name: IL34:CSF1 binds CSF1R See in Reactome R-HSA-9009554 ( R-HSA-449836 ) R-HSA-9009554 Reaction Name: IL34 dimer:SDC1 binds CSF1R See in Reactome
MONDO:0016865	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0027407	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0032772	CSF1R	P07333	2.7.10.1	R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System	R-HSA-6787820 ( R-HSA-449836 ) R-HSA-6787820 Reaction Name: IL34 dimer binds CSF1R See in Reactome R-HSA-8853908 ( R-HSA-8853884 ) R-HSA-8853908 Reaction Name: VENTX stimulates CSF1R (M-CSF-R) expression See in Reactome R-HSA-9009485 ( R-HSA-449836 ) R-HSA-9009485 Reaction Name: IL34:CSF1 binds CSF1R See in Reactome R-HSA-9009554 ( R-HSA-449836 ) R-HSA-9009554 Reaction Name: IL34 dimer:SDC1 binds CSF1R See in Reactome
MONDO:0034143	CSF1R	P07333	2.7.10.1	R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System	R-HSA-6787820 ( R-HSA-449836 ) R-HSA-6787820 Reaction Name: IL34 dimer binds CSF1R See in Reactome R-HSA-8853908 ( R-HSA-8853884 ) R-HSA-8853908 Reaction Name: VENTX stimulates CSF1R (M-CSF-R) expression See in Reactome R-HSA-9009485 ( R-HSA-449836 ) R-HSA-9009485 Reaction Name: IL34:CSF1 binds CSF1R See in Reactome R-HSA-9009554 ( R-HSA-449836 ) R-HSA-9009554 Reaction Name: IL34 dimer:SDC1 binds CSF1R See in Reactome