DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-75205)

Number of enzymes:	3
Number of disease:	5
Number of reactomes:	7
Number of reactions:	33

Search results (Reactome ID: R-HSA-75205)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009009	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0011136	PLAU	P00749	3.4.21.73	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Hemostasis	R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158959 ( R-HSA-75205 ) R-HSA-158959 Reaction Name: urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-159001 ( R-HSA-75205 ) R-HSA-159001 Reaction Name: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-159005 ( R-HSA-75205 ) R-HSA-159005 Reaction Name: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome
MONDO:0012872	PLAT	P00750	3.4.21.68	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome	R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158781 ( R-HSA-75205 ) R-HSA-158781 Reaction Name: crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158795 ( R-HSA-75205 ) R-HSA-158795 Reaction Name: fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 See in Reactome R-HSA-158800 ( R-HSA-75205 ) R-HSA-158800 Reaction Name: fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome
MONDO:0018810	PLAT	P00750	3.4.21.68	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome	R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158781 ( R-HSA-75205 ) R-HSA-158781 Reaction Name: crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158795 ( R-HSA-75205 ) R-HSA-158795 Reaction Name: fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 See in Reactome R-HSA-158800 ( R-HSA-75205 ) R-HSA-158800 Reaction Name: fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome
MONDO:0019623	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome