DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-74752)

Number of enzymes:	1
Number of disease:	6
Number of reactomes:	6
Number of reactions:	14

Search results (Reactome ID: R-HSA-74752)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005148	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome
MONDO:0009517	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome
MONDO:0009734	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome
MONDO:0009874	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome
MONDO:0012381	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome
MONDO:0012520	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome