DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-74259)

Number of enzymes:	5
Number of disease:	6
Number of reactomes:	6
Number of reactions:	19

Search results (Reactome ID: R-HSA-74259)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008895	NT5E	P21589	3.1.3.5	R-HSA-196807 R-HSA-196807 Reactome Name: Nicotinate metabolism See in Reactome R-HSA-74259 R-HSA-74259 Reactome Name: Purine catabolism See in Reactome R-HSA-73621 R-HSA-73621 Reactome Name: Pyrimidine catabolism See in Reactome	R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-109278 ( R-HSA-74259 ) R-HSA-109278 Reaction Name: NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP See in Reactome R-HSA-109291 ( R-HSA-73621 ) R-HSA-109291 Reaction Name: CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] See in Reactome R-HSA-8940070 ( R-HSA-196807 ) R-HSA-8940070 Reaction Name: NT5E:Zn2+ hydrolyses NAD+ See in Reactome R-HSA-8940074 ( R-HSA-196807 ) R-HSA-8940074 Reaction Name: NT5E:Zn2+ hydrolyses NMN See in Reactome
MONDO:0010209	XDH	P47989	1.17.3.2 1.17.1.4	R-HSA-74259 R-HSA-74259 Reactome Name: Purine catabolism See in Reactome R-HSA-8851680 R-HSA-8851680 Reactome Name: Butyrophilin (BTN) family interactions See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Metabolism Immune System	R-HSA-74247 ( R-HSA-74259 ) R-HSA-74247 Reaction Name: XDH oxidizes hypoxanthine to form xanthine See in Reactome R-HSA-74258 ( R-HSA-74259 ) R-HSA-74258 Reaction Name: XDH oxidizes xanthine to form urate See in Reactome R-HSA-8851044 ( R-HSA-8851680 ) R-HSA-8851044 Reaction Name: BTN1A1 binds xanthine oxidoreductase (XDH) See in Reactome R-HSA-9727347 ( R-HSA-74259 ) R-HSA-9727347 Reaction Name: XDH dehydrogenates hypoxanthine to form xanthine See in Reactome R-HSA-9727349 ( R-HSA-74259 ) R-HSA-9727349 Reaction Name: XDH dehydrogenates xanthine to form urate See in Reactome
MONDO:0013165	NT5C2	P49902	2.7.1.77 3.1.3.5 3.1.3.99	R-HSA-74259 R-HSA-74259 Reactome Name: Purine catabolism See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-74248 ( R-HSA-74259 ) R-HSA-74248 Reaction Name: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) See in Reactome
MONDO:0013171	PNP	P00491	2.4.2.1	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-74217 R-HSA-74217 Reactome Name: Purine salvage See in Reactome R-HSA-74259 R-HSA-74259 Reactome Name: Purine catabolism See in Reactome	R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8956321 R-HSA-8956321 Reactome Name: Nucleotide salvage See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Immune System Metabolism	R-HSA-112033 ( R-HSA-74217 ) R-HSA-112033 Reaction Name: PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine See in Reactome R-HSA-112034 ( R-HSA-74217 ) R-HSA-112034 Reaction Name: PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-74242 ( R-HSA-74259 ) R-HSA-74242 Reaction Name: PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose See in Reactome R-HSA-74249 ( R-HSA-74259 ) R-HSA-74249 Reaction Name: PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose See in Reactome
MONDO:0013461	ITPA	Q9BY32	3.6.1.9	R-HSA-74259 R-HSA-74259 Reactome Name: Purine catabolism See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-2509827 ( R-HSA-74259 ) R-HSA-2509827 Reaction Name: ITPA hydrolyses ITP to IMP See in Reactome R-HSA-2509831 ( R-HSA-74259 ) R-HSA-2509831 Reaction Name: ITPA hydrolyses XTP to XMP See in Reactome R-HSA-2509838 ( R-HSA-74259 ) R-HSA-2509838 Reaction Name: ITPA hydrolyses dITP to dIMP See in Reactome
MONDO:0014719	ITPA	Q9BY32	3.6.1.9	R-HSA-74259 R-HSA-74259 Reactome Name: Purine catabolism See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8956319 R-HSA-8956319 Reactome Name: Nucleotide catabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-2509827 ( R-HSA-74259 ) R-HSA-2509827 Reaction Name: ITPA hydrolyses ITP to IMP See in Reactome R-HSA-2509831 ( R-HSA-74259 ) R-HSA-2509831 Reaction Name: ITPA hydrolyses XTP to XMP See in Reactome R-HSA-2509838 ( R-HSA-74259 ) R-HSA-2509838 Reaction Name: ITPA hydrolyses dITP to dIMP See in Reactome