DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-71403)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005212	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0007273	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0007888	FH	P07954	4.2.1.2	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-451033 ( R-HSA-71403 ) R-HSA-451033 Reaction Name: (S)-Malate <=> Fumarate + H2O See in Reactome R-HSA-70982 ( R-HSA-71403 ) R-HSA-70982 Reaction Name: Fumarate + H2O <=> (S)-Malate See in Reactome
MONDO:0008145	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0008233	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0008759	OGDH	Q02218	1.2.4.2	R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-71064 R-HSA-71064 Reactome Name: Lysine catabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome	Metabolism	R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71037 ( R-HSA-71064 ) R-HSA-71037 Reaction Name: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ See in Reactome R-HSA-71401 ( R-HSA-71403 ) R-HSA-71401 Reaction Name: alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ See in Reactome
MONDO:0009504	SUCLG1	P53597	6.2.1.4 6.2.1.5	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-70997 ( R-HSA-71403 ) R-HSA-70997 Reaction Name: ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA See in Reactome R-HSA-71775 ( R-HSA-71403 ) R-HSA-71775 Reaction Name: GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA See in Reactome
MONDO:0009529	DLD	P09622	1.8.1.4	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-71064 R-HSA-71064 Reactome Name: Lysine catabolism See in Reactome R-HSA-6783984 R-HSA-6783984 Reactome Name: Glycine degradation See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-5693148 ( R-HSA-70895 ) R-HSA-5693148 Reaction Name: BCKDK phosphorylates BCKDH See in Reactome R-HSA-5693153 ( R-HSA-70895 ) R-HSA-5693153 Reaction Name: PPM1K dephosphorylates p-BCKDH See in Reactome R-HSA-5694018 ( R-HSA-389661; R-HSA-6783984 ) R-HSA-5694018 Reaction Name: DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-70713 ( R-HSA-70895 ) R-HSA-70713 Reaction Name: BCKDH transfers CoA group from CoA-SH to BCAAs See in Reactome R-HSA-71037 ( R-HSA-71064 ) R-HSA-71037 Reaction Name: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome R-HSA-71401 ( R-HSA-71403 ) R-HSA-71401 Reaction Name: alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ See in Reactome
MONDO:0011424	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0011719	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0011719	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0011730	FH	P07954	4.2.1.2	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-451033 ( R-HSA-71403 ) R-HSA-451033 Reaction Name: (S)-Malate <=> Fumarate + H2O See in Reactome R-HSA-70982 ( R-HSA-71403 ) R-HSA-70982 Reaction Name: Fumarate + H2O <=> (S)-Malate See in Reactome
MONDO:0011740	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0012791	SUCLA2	Q9P2R7	6.2.1.5	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-70997 ( R-HSA-71403 ) R-HSA-70997 Reaction Name: ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA See in Reactome
MONDO:0013339	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0013345	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0013602	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0013802	ACO2	Q99798	4.2.1.3	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome	Metabolism Protein localization	R-HSA-1268022 ( R-HSA-1268020 ) R-HSA-1268022 Reaction Name: TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space See in Reactome R-HSA-450975 ( R-HSA-71403 ) R-HSA-450975 Reaction Name: isocitrate <=> citrate See in Reactome R-HSA-70971 ( R-HSA-71403 ) R-HSA-70971 Reaction Name: citrate <=> isocitrate See in Reactome
MONDO:0013808	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0013874	NNT	Q13423	7.1.1.1	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-450971 ( R-HSA-71403 ) R-HSA-450971 Reaction Name: NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] See in Reactome
MONDO:0014571	ACO2	Q99798	4.2.1.3	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome	Metabolism Protein localization	R-HSA-1268022 ( R-HSA-1268020 ) R-HSA-1268022 Reaction Name: TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space See in Reactome R-HSA-450975 ( R-HSA-71403 ) R-HSA-450975 Reaction Name: isocitrate <=> citrate See in Reactome R-HSA-70971 ( R-HSA-71403 ) R-HSA-70971 Reaction Name: citrate <=> isocitrate See in Reactome
MONDO:0015025	MDH2	P40926	1.1.1.37	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70979 ( R-HSA-71403 ) R-HSA-70979 Reaction Name: (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ See in Reactome R-HSA-71783 ( R-HSA-70263; R-HSA-71403 ) R-HSA-71783 Reaction Name: Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ See in Reactome
MONDO:0015356	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0016063	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0016815	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0017366	FH	P07954	4.2.1.2	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-451033 ( R-HSA-71403 ) R-HSA-451033 Reaction Name: (S)-Malate <=> Fumarate + H2O See in Reactome R-HSA-70982 ( R-HSA-71403 ) R-HSA-70982 Reaction Name: Fumarate + H2O <=> (S)-Malate See in Reactome
MONDO:0017366	DLST	P36957	2.3.1.61	R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-71064 R-HSA-71064 Reactome Name: Lysine catabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome	Metabolism	R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71037 ( R-HSA-71064 ) R-HSA-71037 Reaction Name: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ See in Reactome R-HSA-71401 ( R-HSA-71403 ) R-HSA-71401 Reaction Name: alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ See in Reactome
MONDO:0017366	MDH2	P40926	1.1.1.37	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70979 ( R-HSA-71403 ) R-HSA-70979 Reaction Name: (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ See in Reactome R-HSA-71783 ( R-HSA-70263; R-HSA-71403 ) R-HSA-71783 Reaction Name: Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ See in Reactome
MONDO:0021163	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0024498	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0030974	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0031006	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0032771	DLST	P36957	2.3.1.61	R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-71064 R-HSA-71064 Reactome Name: Lysine catabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome	Metabolism	R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71037 ( R-HSA-71064 ) R-HSA-71037 Reaction Name: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ See in Reactome R-HSA-71401 ( R-HSA-71403 ) R-HSA-71401 Reaction Name: alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ See in Reactome
MONDO:0033563	IDH3A	P50213	1.1.1.41	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-70967 ( R-HSA-71403 ) R-HSA-70967 Reaction Name: isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] See in Reactome
MONDO:0100294	SDHB	P21912	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0100294	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome

Number of enzymes:	13
Number of disease:	32
Number of reactomes:	12
Number of reactions:	25

Search summary (Reactome ID: R-HSA-71403)

Search results (Reactome ID: R-HSA-71403)

MONDO:0005212

R-HSA-611105

R-HSA-71403

R-HSA-1428517

R-HSA-1430728

R-HSA-71406

R-HSA-163200

R-HSA-163213

R-HSA-70994

MONDO:0007273

R-HSA-611105

R-HSA-71403

R-HSA-1428517

R-HSA-1430728

R-HSA-71406

R-HSA-163200

R-HSA-163213

R-HSA-70994

MONDO:0007888

R-HSA-71403

R-HSA-1428517

R-HSA-71406

R-HSA-1430728

R-HSA-451033

R-HSA-70982

MONDO:0008145

R-HSA-71403

R-HSA-2151201

R-HSA-1428517

R-HSA-1852241

R-HSA-71406

R-HSA-1430728

R-HSA-1592230

R-HSA-450984

R-HSA-5688289

MONDO:0008233

R-HSA-611105

R-HSA-71403

R-HSA-1428517

R-HSA-1430728

R-HSA-71406

R-HSA-163200

R-HSA-163213

R-HSA-70994

MONDO:0008759

R-HSA-389661

R-HSA-71403

R-HSA-71064

R-HSA-71291

R-HSA-71406

R-HSA-1430728

R-HSA-1428517

R-HSA-6792572

R-HSA-71037

R-HSA-71401

MONDO:0009504

R-HSA-71403

R-HSA-1428517

R-HSA-71406

R-HSA-1430728

R-HSA-70997

R-HSA-71775

MONDO:0009529

R-HSA-71403

R-HSA-204174

R-HSA-70895

R-HSA-70268

R-HSA-71064

R-HSA-6783984

R-HSA-389661

R-HSA-5362517

R-HSA-71406

R-HSA-71291

R-HSA-9006931

R-HSA-1430728

R-HSA-1428517

R-HSA-162582

R-HSA-203946