DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-70171)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005148	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0005290	PGAM2	P15259	5.4.2.11 5.4.2.4	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-71445 ( R-HSA-70263 ) R-HSA-71445 Reaction Name: 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate See in Reactome R-HSA-71654 ( R-HSA-70171 ) R-HSA-71654 Reaction Name: 3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate See in Reactome
MONDO:0005406	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0007067	PKLR	P30613	2.7.1.40	R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome	Metabolism Developmental Biology	R-HSA-163669 ( R-HSA-163765 ) R-HSA-163669 Reaction Name: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX See in Reactome R-HSA-211461 ( R-HSA-210745 ) R-HSA-211461 Reaction Name: HNF1A-dependent synthesis of the L isoform of PKLR protein See in Reactome R-HSA-71670 ( R-HSA-70171 ) R-HSA-71670 Reaction Name: phosphoenolpyruvate + ADP => pyruvate + ATP See in Reactome
MONDO:0007453	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0009113	BPGM	P07738	5.4.2.11 5.4.2.4	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-6798335 ( R-HSA-70171 ) R-HSA-6798335 Reaction Name: BPGM dimer isomerises 1,3BPG to 2,3BPG See in Reactome
MONDO:0009249	ALDOB	P05062	4.1.2.13	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-70350 R-HSA-70350 Reactome Name: Fructose catabolism See in Reactome	R-HSA-5652084 R-HSA-5652084 Reactome Name: Fructose metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70342 ( R-HSA-70350 ) R-HSA-70342 Reaction Name: ALDOB tetramer cleaves Fru-1-P to GA and DHAP See in Reactome R-HSA-71495 ( R-HSA-70263 ) R-HSA-71495 Reaction Name: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate See in Reactome R-HSA-71496 ( R-HSA-70171 ) R-HSA-71496 Reaction Name: D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate See in Reactome
MONDO:0009295	PFKM	P08237	2.7.1.11	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70467 ( R-HSA-70171 ) R-HSA-70467 Reaction Name: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP See in Reactome
MONDO:0009340	HK1	P19367	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome
MONDO:0009865	PGAM2	P15259	5.4.2.11 5.4.2.4	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-71445 ( R-HSA-70263 ) R-HSA-71445 Reaction Name: 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate See in Reactome R-HSA-71654 ( R-HSA-70171 ) R-HSA-71654 Reaction Name: 3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate See in Reactome
MONDO:0009950	PKLR	P30613	2.7.1.40	R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome	Metabolism Developmental Biology	R-HSA-163669 ( R-HSA-163765 ) R-HSA-163669 Reaction Name: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX See in Reactome R-HSA-211461 ( R-HSA-210745 ) R-HSA-211461 Reaction Name: HNF1A-dependent synthesis of the L isoform of PKLR protein See in Reactome R-HSA-71670 ( R-HSA-70171 ) R-HSA-71670 Reaction Name: phosphoenolpyruvate + ADP => pyruvate + ATP See in Reactome
MONDO:0010392	PGK1	P00558	2.7.2.3	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70486 ( R-HSA-70263 ) R-HSA-70486 Reaction Name: ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate See in Reactome R-HSA-71850 ( R-HSA-70171 ) R-HSA-71850 Reaction Name: 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP See in Reactome
MONDO:0011236	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0011534	HK1	P19367	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome
MONDO:0012747	ALDOA	P04075	4.1.2.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Immune System Metabolism Hemostasis	R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-71495 ( R-HSA-70263 ) R-HSA-71495 Reaction Name: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate See in Reactome R-HSA-71496 ( R-HSA-70171 ) R-HSA-71496 Reaction Name: D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate See in Reactome
MONDO:0013046	ENO3	P13929	4.2.1.11	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70494 ( R-HSA-70263 ) R-HSA-70494 Reaction Name: Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate See in Reactome R-HSA-71660 ( R-HSA-70171 ) R-HSA-71660 Reaction Name: 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O See in Reactome
MONDO:0013275	GPI	P06744	5.3.1.9	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Immune System Metabolism Gene expression (Transcription)	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-70471 ( R-HSA-70171 ) R-HSA-70471 Reaction Name: alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate See in Reactome R-HSA-70475 ( R-HSA-5628897; R-HSA-70263 ) R-HSA-70475 Reaction Name: D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate See in Reactome
MONDO:0014221	TPI1	P60174	5.3.1.1 4.2.3.3	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70454 ( R-HSA-70171 ) R-HSA-70454 Reaction Name: dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate See in Reactome R-HSA-70481 ( R-HSA-70263 ) R-HSA-70481 Reaction Name: D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate See in Reactome
MONDO:0015967	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0020091	PGK1	P00558	2.7.2.3	R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70486 ( R-HSA-70263 ) R-HSA-70486 Reaction Name: ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate See in Reactome R-HSA-71850 ( R-HSA-70171 ) R-HSA-71850 Reaction Name: 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP See in Reactome
MONDO:0032807	HK1	P19367	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome
MONDO:0044320	HK1	P19367	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome
MONDO:0100165	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome

Number of enzymes:	12
Number of disease:	23
Number of reactomes:	10
Number of reactions:	30

Search summary (Reactome ID: R-HSA-70171)

Search results (Reactome ID: R-HSA-70171)

MONDO:0005148

R-HSA-70171

R-HSA-210745

R-HSA-9615017

R-HSA-170822

R-HSA-186712

R-HSA-9614085

R-HSA-74160

R-HSA-70326

R-HSA-212436

R-HSA-1430728

R-HSA-73857

R-HSA-1266738

R-HSA-71387

R-HSA-170796

R-HSA-170799

R-HSA-170810

R-HSA-170824

R-HSA-170825

R-HSA-211346

R-HSA-70420

R-HSA-9625124

MONDO:0005290

R-HSA-70263

R-HSA-70171

R-HSA-1430728

R-HSA-70326

R-HSA-71387

R-HSA-71445

R-HSA-71654

MONDO:0005406

R-HSA-70171

R-HSA-210745

R-HSA-9615017

R-HSA-170822

R-HSA-186712

R-HSA-9614085

R-HSA-74160

R-HSA-70326

R-HSA-212436

R-HSA-1430728

R-HSA-73857

R-HSA-1266738

R-HSA-71387

R-HSA-170796

R-HSA-170799

R-HSA-170810

R-HSA-170824

R-HSA-170825

R-HSA-211346

R-HSA-70420

R-HSA-9625124

MONDO:0007067

R-HSA-163765

R-HSA-210745

R-HSA-70171

R-HSA-70326

R-HSA-71387

R-HSA-163685

R-HSA-1430728

R-HSA-1266738

R-HSA-186712

R-HSA-163669

R-HSA-211461

R-HSA-71670

MONDO:0007453

R-HSA-70171

R-HSA-210745

R-HSA-9615017

R-HSA-170822

R-HSA-186712

R-HSA-9614085

R-HSA-74160

R-HSA-70326

R-HSA-212436

R-HSA-1430728

R-HSA-73857

R-HSA-1266738