MONDO:0002629 |
MONDO:0002629
Disease Name: bone osteosarcoma
OMIM id: OMIM:259500
Orphanet id: Orphanet:668
All associated enzymes in DAR:
CHEK2
. The disease is also associated to other non-enzyme proteins (not in DAR).
CHEK2 |
O96017 |
2.7.11.1
|
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-69541
R-HSA-75035
R-HSA-75035
Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-69615
R-HSA-69481
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-69620
R-HSA-212436
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1640170
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
|
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683774
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
Reaction Name: p-T68-CHEK2 autophosphorylates
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-6804266
(
R-HSA-6804760
)
R-HSA-69608
(
R-HSA-69601
)
R-HSA-69608
Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2
See in Reactome
R-HSA-69685
(
R-HSA-6804756;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-75809
(
R-HSA-69473;
R-HSA-75035
)
R-HSA-75809
Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2
See in Reactome
|
MONDO:0004948 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
WRN |
Q14191 |
3.6.4.12
3.1.-.-
|
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-174414
R-HSA-174414
Reactome Name: Processive synthesis on the C-strand of the telomere
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-174437
R-HSA-174437
Reactome Name: Removal of the Flap Intermediate from the C-strand
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-157579
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-174417
R-HSA-174417
Reactome Name: Telomere C-strand (Lagging Strand) Synthesis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-180786
R-HSA-2990846
R-HSA-73886
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
|
R-HSA-174438
(
R-HSA-174414
)
R-HSA-174438
Reaction Name: Formation of the Flap Intermediate on the C-strand
See in Reactome
R-HSA-174446
(
R-HSA-174414;
R-HSA-174437
)
R-HSA-174446
Reaction Name: Removal of remaining Flap from the C-strand
See in Reactome
R-HSA-4568846
(
R-HSA-3108214
)
R-HSA-4568846
Reaction Name: CDKN2A (p14-ARF) SUMOylates WRN with SUMO1
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
|
MONDO:0006033 |
BRIP1 |
Q9BX63 |
3.6.4.13
|
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-2564830
R-HSA-2564830
Reactome Name: Cytosolic iron-sulfur cluster assembly
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-69620
R-HSA-73894
R-HSA-1430728
R-HSA-1640170
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
DNA Repair
Metabolism
Cell Cycle
|
R-HSA-2564828
(
R-HSA-2564830
)
R-HSA-2564828
Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
|
MONDO:0008170 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0008840 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0008869 |
ATR |
Q13535 |
2.7.11.1
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-69473
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-6783310
R-HSA-176187
R-HSA-176187
Reactome Name: Activation of ATR in response to replication stress
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-5633007
R-HSA-69481
R-HSA-69620
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-2262752
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-1500620
R-HSA-5693538
R-HSA-1640170
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
Cell Cycle
DNA Repair
Reproduction
|
R-HSA-176116
(
R-HSA-176187;
R-HSA-69473
)
R-HSA-176116
Reaction Name: Recruitment and activation of Chk1
See in Reactome
R-HSA-176250
(
R-HSA-176187
)
R-HSA-176250
Reaction Name: Binding of ATR-ATRIP to the RPA-ssDNA complex
See in Reactome
R-HSA-176298
(
R-HSA-176187
)
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-6788385
(
R-HSA-6783310
)
R-HSA-6788385
Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA
See in Reactome
R-HSA-6788392
(
R-HSA-6783310
)
R-HSA-6788392
Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
|
MONDO:0008876 |
BLM |
P54132 |
3.6.4.12
|
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-174414
R-HSA-174414
Reactome Name: Processive synthesis on the C-strand of the telomere
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73857
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-69620
R-HSA-2990846
R-HSA-73886
R-HSA-1474165
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-174417
R-HSA-174417
Reactome Name: Telomere C-strand (Lagging Strand) Synthesis
See in Reactome
R-HSA-157579
R-HSA-392499
R-HSA-69481
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-180786
R-HSA-5693538
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Gene expression (Transcription)
Reproduction
Metabolism of proteins
DNA Repair
|
R-HSA-174438
(
R-HSA-174414
)
R-HSA-174438
Reaction Name: Formation of the Flap Intermediate on the C-strand
See in Reactome
R-HSA-4568914
(
R-HSA-3108214
)
R-HSA-4568914
Reaction Name: SUMOylation of BLM with SUMO2,3
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686398
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686398
Reaction Name: SPIDR binds BLM:TOP3A:RMI1:RMI2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
|
MONDO:0009215 |
BRCA1 |
P38398 |
2.3.2.27
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-1500620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-5688426
R-HSA-2990846
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
Reproduction
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9007605
(
R-HSA-8953750
)
R-HSA-9007605
Reaction Name: BRCA1 gene expression is inhibited by E2F6
See in Reactome
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912467
(
R-HSA-1221632
)
R-HSA-912467
Reaction Name: BRCA1 is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0009622 |
RBBP8 |
Q99708 |
3.1.-.-
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5685939
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-1500620
R-HSA-1640170
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
Reproduction
|
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685953
(
R-HSA-5693607
)
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5687464
(
R-HSA-5685939
)
R-HSA-5687464
Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ
See in Reactome
R-HSA-5687465
(
R-HSA-5685939
)
R-HSA-5687484
(
R-HSA-5685939
)
R-HSA-5687484
Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
See in Reactome
R-HSA-5687640
(
R-HSA-5685939
)
R-HSA-5687640
Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ
See in Reactome
R-HSA-5687653
(
R-HSA-5685939
)
R-HSA-5687653
Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
See in Reactome
R-HSA-5687664
(
R-HSA-5685939
)
R-HSA-5687664
Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ
See in Reactome
R-HSA-5687673
(
R-HSA-5685939
)
R-HSA-5687673
Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites
See in Reactome
R-HSA-5687675
(
R-HSA-5685939
)
R-HSA-5687675
Reaction Name: LIG3 ligates remaining SSBs in MMEJ
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-9007625
(
R-HSA-8953750
)
R-HSA-9007625
Reaction Name: RBBP8 gene expression is inhibited by E2F6
See in Reactome
R-HSA-9023941
(
R-HSA-912446
)
R-HSA-9023941
Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11
See in Reactome
R-HSA-9023943
(
R-HSA-912446
)
R-HSA-9023943
Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end
See in Reactome
|
MONDO:0010196 |
WRN |
Q14191 |
3.6.4.12
3.1.-.-
|
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-174414
R-HSA-174414
Reactome Name: Processive synthesis on the C-strand of the telomere
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-174437
R-HSA-174437
Reactome Name: Removal of the Flap Intermediate from the C-strand
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-157579
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-174417
R-HSA-174417
Reactome Name: Telomere C-strand (Lagging Strand) Synthesis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-180786
R-HSA-2990846
R-HSA-73886
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
|
R-HSA-174438
(
R-HSA-174414
)
R-HSA-174438
Reaction Name: Formation of the Flap Intermediate on the C-strand
See in Reactome
R-HSA-174446
(
R-HSA-174414;
R-HSA-174437
)
R-HSA-174446
Reaction Name: Removal of remaining Flap from the C-strand
See in Reactome
R-HSA-4568846
(
R-HSA-3108214
)
R-HSA-4568846
Reaction Name: CDKN2A (p14-ARF) SUMOylates WRN with SUMO1
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
|