DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-69205)

Number of enzymes:	2
Number of disease:	3
Number of reactomes:	11
Number of reactions:	22

Search results (Reactome ID: R-HSA-69205)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010523	POLA1	P09884	2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-174430 R-HSA-174430 Reactome Name: Telomere C-strand synthesis initiation See in Reactome R-HSA-113501 R-HSA-113501 Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1 See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113504 ( R-HSA-113501 ) R-HSA-113504 Reaction Name: Detection of damage during initiation of DNA synthesis in S-phase See in Reactome R-HSA-174425 ( R-HSA-174430 ) R-HSA-174425 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere See in Reactome R-HSA-174427 ( R-HSA-174430 ) R-HSA-174427 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere See in Reactome R-HSA-174452 ( R-HSA-174411 ) R-HSA-174452 Reaction Name: RFC binding displaces Pol Alpha on the C-strand of the telomere See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68950 ( R-HSA-68952 ) R-HSA-68950 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin See in Reactome R-HSA-69053 ( R-HSA-69091 ) R-HSA-69053 Reaction Name: RFC binding displaces Pol Alpha See in Reactome R-HSA-69063 ( R-HSA-69091 ) R-HSA-69063 Reaction Name: Loading of PCNA - Sliding Clamp Formation See in Reactome R-HSA-69068 ( R-HSA-69091 ) R-HSA-69068 Reaction Name: RFC dissociates after sliding clamp formation See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome R-HSA-8961632 ( R-HSA-69205 ) R-HSA-8961632 Reaction Name: POLA1 gene transcription is stimulated by E2F1 See in Reactome R-HSA-9668597 ( R-HSA-174430 ) R-HSA-9668597 Reaction Name: DNA polymerase:primase binds G-strand of the telomere See in Reactome
MONDO:0013456	DHFR	P00374	1.5.1.3	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism Cell Cycle	R-HSA-1497794 ( R-HSA-1474151 ) R-HSA-1497794 Reaction Name: Salvage - BH2 is reduced to BH4 by DHFR See in Reactome R-HSA-8961874 ( R-HSA-69205 ) R-HSA-8961874 Reaction Name: DHFR gene expression is stimulated by E2F1 See in Reactome R-HSA-9709098 ( R-HSA-196757 ) R-HSA-9709098 Reaction Name: DHFR dimer reduces FOLA to DHF See in Reactome
MONDO:0015601	POLA1	P09884	2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-174430 R-HSA-174430 Reactome Name: Telomere C-strand synthesis initiation See in Reactome R-HSA-113501 R-HSA-113501 Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1 See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113504 ( R-HSA-113501 ) R-HSA-113504 Reaction Name: Detection of damage during initiation of DNA synthesis in S-phase See in Reactome R-HSA-174425 ( R-HSA-174430 ) R-HSA-174425 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere See in Reactome R-HSA-174427 ( R-HSA-174430 ) R-HSA-174427 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere See in Reactome R-HSA-174452 ( R-HSA-174411 ) R-HSA-174452 Reaction Name: RFC binding displaces Pol Alpha on the C-strand of the telomere See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68950 ( R-HSA-68952 ) R-HSA-68950 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin See in Reactome R-HSA-69053 ( R-HSA-69091 ) R-HSA-69053 Reaction Name: RFC binding displaces Pol Alpha See in Reactome R-HSA-69063 ( R-HSA-69091 ) R-HSA-69063 Reaction Name: Loading of PCNA - Sliding Clamp Formation See in Reactome R-HSA-69068 ( R-HSA-69091 ) R-HSA-69068 Reaction Name: RFC dissociates after sliding clamp formation See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome R-HSA-8961632 ( R-HSA-69205 ) R-HSA-8961632 Reaction Name: POLA1 gene transcription is stimulated by E2F1 See in Reactome R-HSA-9668597 ( R-HSA-174430 ) R-HSA-9668597 Reaction Name: DNA polymerase:primase binds G-strand of the telomere See in Reactome