DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-68962)

Number of enzymes:	8
Number of disease:	13
Number of reactomes:	24
Number of reactions:	64

Search results (Reactome ID: R-HSA-68962)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0006065	MCM6	Q14566	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757257 ( R-HSA-68867 ) R-HSA-9757257 Reaction Name: MCM4, MCM6 and MCM7 form a heterotrimer See in Reactome R-HSA-9757258 ( R-HSA-68867 ) R-HSA-9757258 Reaction Name: MCM2 binds MCM4:MCM6:MCM7 heterotrimer See in Reactome
MONDO:0010523	POLA1	P09884	2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-174430 R-HSA-174430 Reactome Name: Telomere C-strand synthesis initiation See in Reactome R-HSA-113501 R-HSA-113501 Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1 See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113504 ( R-HSA-113501 ) R-HSA-113504 Reaction Name: Detection of damage during initiation of DNA synthesis in S-phase See in Reactome R-HSA-174425 ( R-HSA-174430 ) R-HSA-174425 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere See in Reactome R-HSA-174427 ( R-HSA-174430 ) R-HSA-174427 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere See in Reactome R-HSA-174452 ( R-HSA-174411 ) R-HSA-174452 Reaction Name: RFC binding displaces Pol Alpha on the C-strand of the telomere See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68950 ( R-HSA-68952 ) R-HSA-68950 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin See in Reactome R-HSA-69053 ( R-HSA-69091 ) R-HSA-69053 Reaction Name: RFC binding displaces Pol Alpha See in Reactome R-HSA-69063 ( R-HSA-69091 ) R-HSA-69063 Reaction Name: Loading of PCNA - Sliding Clamp Formation See in Reactome R-HSA-69068 ( R-HSA-69091 ) R-HSA-69068 Reaction Name: RFC dissociates after sliding clamp formation See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome R-HSA-8961632 ( R-HSA-69205 ) R-HSA-8961632 Reaction Name: POLA1 gene transcription is stimulated by E2F1 See in Reactome R-HSA-9668597 ( R-HSA-174430 ) R-HSA-9668597 Reaction Name: DNA polymerase:primase binds G-strand of the telomere See in Reactome
MONDO:0012383	MCM4	P33991	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757257 ( R-HSA-68867 ) R-HSA-9757257 Reaction Name: MCM4, MCM6 and MCM7 form a heterotrimer See in Reactome R-HSA-9757258 ( R-HSA-68867 ) R-HSA-9757258 Reaction Name: MCM2 binds MCM4:MCM6:MCM7 heterotrimer See in Reactome
MONDO:0013873	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014038	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014058	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014853	MCM2	P49736	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757258 ( R-HSA-68867 ) R-HSA-9757258 Reaction Name: MCM2 binds MCM4:MCM6:MCM7 heterotrimer See in Reactome
MONDO:0015601	POLA1	P09884	2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-174430 R-HSA-174430 Reactome Name: Telomere C-strand synthesis initiation See in Reactome R-HSA-113501 R-HSA-113501 Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1 See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113504 ( R-HSA-113501 ) R-HSA-113504 Reaction Name: Detection of damage during initiation of DNA synthesis in S-phase See in Reactome R-HSA-174425 ( R-HSA-174430 ) R-HSA-174425 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere See in Reactome R-HSA-174427 ( R-HSA-174430 ) R-HSA-174427 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere See in Reactome R-HSA-174452 ( R-HSA-174411 ) R-HSA-174452 Reaction Name: RFC binding displaces Pol Alpha on the C-strand of the telomere See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68950 ( R-HSA-68952 ) R-HSA-68950 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin See in Reactome R-HSA-69053 ( R-HSA-69091 ) R-HSA-69053 Reaction Name: RFC binding displaces Pol Alpha See in Reactome R-HSA-69063 ( R-HSA-69091 ) R-HSA-69063 Reaction Name: Loading of PCNA - Sliding Clamp Formation See in Reactome R-HSA-69068 ( R-HSA-69091 ) R-HSA-69068 Reaction Name: RFC dissociates after sliding clamp formation See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome R-HSA-8961632 ( R-HSA-69205 ) R-HSA-8961632 Reaction Name: POLA1 gene transcription is stimulated by E2F1 See in Reactome R-HSA-9668597 ( R-HSA-174430 ) R-HSA-9668597 Reaction Name: DNA polymerase:primase binds G-strand of the telomere See in Reactome
MONDO:0017950	PRIM1	P49642	2.7.7.102	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-174430 R-HSA-174430 Reactome Name: Telomere C-strand synthesis initiation See in Reactome R-HSA-113501 R-HSA-113501 Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1 See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113504 ( R-HSA-113501 ) R-HSA-113504 Reaction Name: Detection of damage during initiation of DNA synthesis in S-phase See in Reactome R-HSA-174425 ( R-HSA-174430 ) R-HSA-174425 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere See in Reactome R-HSA-174427 ( R-HSA-174430 ) R-HSA-174427 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere See in Reactome R-HSA-174452 ( R-HSA-174411 ) R-HSA-174452 Reaction Name: RFC binding displaces Pol Alpha on the C-strand of the telomere See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68950 ( R-HSA-68952 ) R-HSA-68950 Reaction Name: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin See in Reactome R-HSA-69053 ( R-HSA-69091 ) R-HSA-69053 Reaction Name: RFC binding displaces Pol Alpha See in Reactome R-HSA-69063 ( R-HSA-69091 ) R-HSA-69063 Reaction Name: Loading of PCNA - Sliding Clamp Formation See in Reactome R-HSA-69068 ( R-HSA-69091 ) R-HSA-69068 Reaction Name: RFC dissociates after sliding clamp formation See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome R-HSA-9668597 ( R-HSA-174430 ) R-HSA-9668597 Reaction Name: DNA polymerase:primase binds G-strand of the telomere See in Reactome
MONDO:0018653	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0032684	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0033046	MCM5	P33992	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757256 ( R-HSA-68867 ) R-HSA-9757256 Reaction Name: MCM3 binds MCM5 See in Reactome
MONDO:0044776	MCM8	Q9UJA3	3.6.4.12	R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68689 R-HSA-68689 Reactome Name: CDC6 association with the ORC:origin complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome R-HSA-113507 R-HSA-113507 Reactome Name: E2F-enabled inhibition of pre-replication complex formation See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113638 ( R-HSA-113507 ) R-HSA-113638 Reaction Name: Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation See in Reactome R-HSA-169461 ( R-HSA-176974 ) R-HSA-169461 Reaction Name: MCM8 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-68688 ( R-HSA-68689; R-HSA-68867 ) R-HSA-68688 Reaction Name: CDC6 association with ORC(1-6) at replication origins See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-9749215 ( R-HSA-68689; R-HSA-68867 ) R-HSA-9749215 Reaction Name: MCM8 binds CDC6 See in Reactome