DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-6809371)

Number of enzymes:	7
Number of disease:	16
Number of reactomes:	3
Number of reactions:	16

Search results (Reactome ID: R-HSA-6809371)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005010	CELA2A	P08217	3.4.21.71	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849857 ( R-HSA-6809371 ) R-HSA-8849857 Reaction Name: KLK5 cleaves and activates CELA2 See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0005044	CELA2A	P08217	3.4.21.71	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849857 ( R-HSA-6809371 ) R-HSA-8849857 Reaction Name: KLK5 cleaves and activates CELA2 See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0005347	CELA2A	P08217	3.4.21.71	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849857 ( R-HSA-6809371 ) R-HSA-8849857 Reaction Name: KLK5 cleaves and activates CELA2 See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0009441	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0011218	ST14	Q9Y5Y6	3.4.21.109	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849797 ( R-HSA-6809371 ) R-HSA-8849797 Reaction Name: Membrane proteases cleave Profilaggrin producing Filaggrin See in Reactome R-HSA-8849826 ( R-HSA-6809371 ) R-HSA-8849826 Reaction Name: ST14 hydrolyzes and activates KLK5 See in Reactome
MONDO:0012345	TGM5	O43548	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome
MONDO:0013495	LIPN	Q5VXI9	3.1.1.-	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6789310 ( R-HSA-6809371 ) R-HSA-6789310 Reaction Name: LIPs hydrolyse TG to DAG and RCOOH See in Reactome
MONDO:0014431	CELA2A	P08217	3.4.21.71	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849857 ( R-HSA-6809371 ) R-HSA-8849857 Reaction Name: KLK5 cleaves and activates CELA2 See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0014827	CAPN1	P07384	3.4.22.52	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Extracellular matrix organization Immune System Developmental Biology	R-HSA-2534260 ( R-HSA-1474228 ) R-HSA-2534260 Reaction Name: E-cadherin degradation by caspase-3 and calpain-1 See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0015018	CASP14	P31944	3.4.22.-	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0015085	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017267	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017268	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017778	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0019306	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0032837	CELA2A	P08217	3.4.21.71	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849857 ( R-HSA-6809371 ) R-HSA-8849857 Reaction Name: KLK5 cleaves and activates CELA2 See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome