DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-6807004)

Number of enzymes:	4
Number of disease:	13
Number of reactomes:	35
Number of reactions:	130

Search results (Reactome ID: R-HSA-6807004)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0003789	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0005138	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0005575	PTPRJ	Q12913	3.1.3.48	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-202427 R-HSA-202427 Reactome Name: Phosphorylation of CD3 and TCR zeta chains See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-202214 ( R-HSA-202427 ) R-HSA-202214 Reaction Name: Dephosphorylation of Lck-pY505 by CD45 See in Reactome R-HSA-202233 ( R-HSA-202427 ) R-HSA-202233 Reaction Name: Inactivation of Lck by Csk See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-9698408 ( R-HSA-9706369 ) R-HSA-9698408 Reaction Name: PTPRJ dephosphorylates active FLT3 See in Reactome
MONDO:0008104	CBL	P22681	2.3.2.27	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Vesicle-mediated transport Signal Transduction	R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1295621 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295621 Reaction Name: CBL dissociates from ubiquitinated p-SPRY2 See in Reactome R-HSA-1295622 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295622 Reaction Name: SPRY2 binds CBL See in Reactome R-HSA-182969 ( R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182988 ( R-HSA-182971 ) R-HSA-182988 Reaction Name: Sprouty lures CBL away from EGFR See in Reactome R-HSA-182990 ( R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183052 ( R-HSA-182971 ) R-HSA-183052 Reaction Name: CBL binds to GRB2 See in Reactome R-HSA-183055 ( R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-183094 ( R-HSA-182971 ) R-HSA-183094 Reaction Name: CDC42:GTP binds CBL:Beta-Pix See in Reactome R-HSA-205244 ( R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8848818 ( R-HSA-8849469 ) R-HSA-8848818 Reaction Name: PTK6 phosphorylates CBL See in Reactome R-HSA-8848829 ( R-HSA-8849469 ) R-HSA-8848829 Reaction Name: CBL autoubiquitinates See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8951490 ( R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-912724 ( R-HSA-912631 ) R-HSA-912724 Reaction Name: CBL binds B-cell linker protein See in Reactome R-HSA-912727 ( R-HSA-912631 ) R-HSA-912727 Reaction Name: CBL binds VAV See in Reactome R-HSA-912734 ( R-HSA-912631 ) R-HSA-912734 Reaction Name: CBL:CRKL binds RAPGEF1 See in Reactome R-HSA-912790 ( R-HSA-912631 ) R-HSA-912790 Reaction Name: CBL binds CRK See in Reactome R-HSA-934604 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-934604 Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL See in Reactome R-HSA-9706293 ( R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706350 ( R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome
MONDO:0009050	USP8	P40818	3.4.19.12	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-4641263 R-HSA-4641263 Reactome Name: Regulation of FZD by ubiquitination See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1358795 ( R-HSA-1358803 ) R-HSA-1358795 Reaction Name: Deubiquitination of RNF41 by P-USP8 See in Reactome R-HSA-1358797 ( R-HSA-1358803 ) R-HSA-1358797 Reaction Name: Ubiquitinated RNF41 binds P-USP8 See in Reactome R-HSA-4641236 ( R-HSA-4641263 ) R-HSA-4641236 Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling See in Reactome R-HSA-5690196 ( R-HSA-5689880 ) R-HSA-5690196 Reaction Name: USP8 deubiquitinates RNF128 See in Reactome R-HSA-6782628 ( R-HSA-5689880 ) R-HSA-6782628 Reaction Name: USP8 deubiquitinates STAM2:HGS See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome
MONDO:0011806	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0011908	CBL	P22681	2.3.2.27	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Vesicle-mediated transport Signal Transduction	R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1295621 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295621 Reaction Name: CBL dissociates from ubiquitinated p-SPRY2 See in Reactome R-HSA-1295622 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295622 Reaction Name: SPRY2 binds CBL See in Reactome R-HSA-182969 ( R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182988 ( R-HSA-182971 ) R-HSA-182988 Reaction Name: Sprouty lures CBL away from EGFR See in Reactome R-HSA-182990 ( R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183052 ( R-HSA-182971 ) R-HSA-183052 Reaction Name: CBL binds to GRB2 See in Reactome R-HSA-183055 ( R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-183094 ( R-HSA-182971 ) R-HSA-183094 Reaction Name: CDC42:GTP binds CBL:Beta-Pix See in Reactome R-HSA-205244 ( R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8848818 ( R-HSA-8849469 ) R-HSA-8848818 Reaction Name: PTK6 phosphorylates CBL See in Reactome R-HSA-8848829 ( R-HSA-8849469 ) R-HSA-8848829 Reaction Name: CBL autoubiquitinates See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8951490 ( R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-912724 ( R-HSA-912631 ) R-HSA-912724 Reaction Name: CBL binds B-cell linker protein See in Reactome R-HSA-912727 ( R-HSA-912631 ) R-HSA-912727 Reaction Name: CBL binds VAV See in Reactome R-HSA-912734 ( R-HSA-912631 ) R-HSA-912734 Reaction Name: CBL:CRKL binds RAPGEF1 See in Reactome R-HSA-912790 ( R-HSA-912631 ) R-HSA-912790 Reaction Name: CBL binds CRK See in Reactome R-HSA-934604 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-934604 Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL See in Reactome R-HSA-9706293 ( R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706350 ( R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome
MONDO:0013308	CBL	P22681	2.3.2.27	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Vesicle-mediated transport Signal Transduction	R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1295621 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295621 Reaction Name: CBL dissociates from ubiquitinated p-SPRY2 See in Reactome R-HSA-1295622 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295622 Reaction Name: SPRY2 binds CBL See in Reactome R-HSA-182969 ( R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182988 ( R-HSA-182971 ) R-HSA-182988 Reaction Name: Sprouty lures CBL away from EGFR See in Reactome R-HSA-182990 ( R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183052 ( R-HSA-182971 ) R-HSA-183052 Reaction Name: CBL binds to GRB2 See in Reactome R-HSA-183055 ( R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-183094 ( R-HSA-182971 ) R-HSA-183094 Reaction Name: CDC42:GTP binds CBL:Beta-Pix See in Reactome R-HSA-205244 ( R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8848818 ( R-HSA-8849469 ) R-HSA-8848818 Reaction Name: PTK6 phosphorylates CBL See in Reactome R-HSA-8848829 ( R-HSA-8849469 ) R-HSA-8848829 Reaction Name: CBL autoubiquitinates See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8951490 ( R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-912724 ( R-HSA-912631 ) R-HSA-912724 Reaction Name: CBL binds B-cell linker protein See in Reactome R-HSA-912727 ( R-HSA-912631 ) R-HSA-912727 Reaction Name: CBL binds VAV See in Reactome R-HSA-912734 ( R-HSA-912631 ) R-HSA-912734 Reaction Name: CBL:CRKL binds RAPGEF1 See in Reactome R-HSA-912790 ( R-HSA-912631 ) R-HSA-912790 Reaction Name: CBL binds CRK See in Reactome R-HSA-934604 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-934604 Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL See in Reactome R-HSA-9706293 ( R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706350 ( R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome
MONDO:0014739	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0015356	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0018055	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0018416	USP8	P40818	3.4.19.12	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-4641263 R-HSA-4641263 Reactome Name: Regulation of FZD by ubiquitination See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1358795 ( R-HSA-1358803 ) R-HSA-1358795 Reaction Name: Deubiquitination of RNF41 by P-USP8 See in Reactome R-HSA-1358797 ( R-HSA-1358803 ) R-HSA-1358797 Reaction Name: Ubiquitinated RNF41 binds P-USP8 See in Reactome R-HSA-4641236 ( R-HSA-4641263 ) R-HSA-4641236 Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling See in Reactome R-HSA-5690196 ( R-HSA-5689880 ) R-HSA-5690196 Reaction Name: USP8 deubiquitinates RNF128 See in Reactome R-HSA-6782628 ( R-HSA-5689880 ) R-HSA-6782628 Reaction Name: USP8 deubiquitinates STAM2:HGS See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome
MONDO:0020333	CBL	P22681	2.3.2.27	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Vesicle-mediated transport Signal Transduction	R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1295621 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295621 Reaction Name: CBL dissociates from ubiquitinated p-SPRY2 See in Reactome R-HSA-1295622 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295622 Reaction Name: SPRY2 binds CBL See in Reactome R-HSA-182969 ( R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182988 ( R-HSA-182971 ) R-HSA-182988 Reaction Name: Sprouty lures CBL away from EGFR See in Reactome R-HSA-182990 ( R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183052 ( R-HSA-182971 ) R-HSA-183052 Reaction Name: CBL binds to GRB2 See in Reactome R-HSA-183055 ( R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-183094 ( R-HSA-182971 ) R-HSA-183094 Reaction Name: CDC42:GTP binds CBL:Beta-Pix See in Reactome R-HSA-205244 ( R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8848818 ( R-HSA-8849469 ) R-HSA-8848818 Reaction Name: PTK6 phosphorylates CBL See in Reactome R-HSA-8848829 ( R-HSA-8849469 ) R-HSA-8848829 Reaction Name: CBL autoubiquitinates See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8951490 ( R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-912724 ( R-HSA-912631 ) R-HSA-912724 Reaction Name: CBL binds B-cell linker protein See in Reactome R-HSA-912727 ( R-HSA-912631 ) R-HSA-912727 Reaction Name: CBL binds VAV See in Reactome R-HSA-912734 ( R-HSA-912631 ) R-HSA-912734 Reaction Name: CBL:CRKL binds RAPGEF1 See in Reactome R-HSA-912790 ( R-HSA-912631 ) R-HSA-912790 Reaction Name: CBL binds CRK See in Reactome R-HSA-934604 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-934604 Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL See in Reactome R-HSA-9706293 ( R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706350 ( R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome