DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-6804758)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000087	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0001071	CHD3	Q12873	3.6.4.12	R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-3769447 ( R-HSA-3214815 ) R-HSA-3769447 Reaction Name: HDAC1:2-containing complex deacetylate histones See in Reactome R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-8943780 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8943780 Reaction Name: SALL4 recruits NuRD to PTEN gene See in Reactome R-HSA-8944104 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-8956365 ( R-HSA-4551638 ) R-HSA-8956365 Reaction Name: ZBED1 (DREF) SUMOylates CHD3 with SUMO1 See in Reactome R-HSA-9679787 ( R-HSA-3214815 ) R-HSA-9679787 Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors See in Reactome
MONDO:0002407	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005097	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0005148	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005233	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005335	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005575	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005575	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0005611	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0007959	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0008170	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008318	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008393	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0009416	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0010150	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0011240	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0013364	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0014048	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0014407	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0014558	KAT6A	Q92794	2.3.1.48	R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Chromatin organization	R-HSA-3318486 ( R-HSA-3214847 ) R-HSA-3318486 Reaction Name: KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 See in Reactome R-HSA-5579023 ( R-HSA-3214847 ) R-HSA-5579023 Reaction Name: NCOA2(869-1464) binds KAT6A(1-1118) See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805638 ( R-HSA-6804758 ) R-HSA-6805638 Reaction Name: KAT6A acetylates TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome
MONDO:0014946	CHD4	Q14839	3.6.4.12	R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Chromatin organization Signal Transduction	R-HSA-3769447 ( R-HSA-3214815 ) R-HSA-3769447 Reaction Name: HDAC1:2-containing complex deacetylate histones See in Reactome R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-8943780 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8943780 Reaction Name: SALL4 recruits NuRD to PTEN gene See in Reactome R-HSA-8944104 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-9612534 ( R-HSA-9031628 ) R-HSA-9612534 Reaction Name: Expression of ID2 and ID4 is repressed by EGR2:NAB See in Reactome R-HSA-9613213 ( R-HSA-9031628 ) R-HSA-9613213 Reaction Name: NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression See in Reactome R-HSA-9613219 ( R-HSA-9031628 ) R-HSA-9613219 Reaction Name: RRAD gene expression See in Reactome R-HSA-9613476 ( R-HSA-9031628 ) R-HSA-9613476 Reaction Name: EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions See in Reactome R-HSA-9679787 ( R-HSA-3214815 ) R-HSA-9679787 Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors See in Reactome
MONDO:0016419	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016642	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0019086	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0019192	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0020492	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0020769	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0021230	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0032600	CHD3	Q12873	3.6.4.12	R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-3769447 ( R-HSA-3214815 ) R-HSA-3769447 Reaction Name: HDAC1:2-containing complex deacetylate histones See in Reactome R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-8943780 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8943780 Reaction Name: SALL4 recruits NuRD to PTEN gene See in Reactome R-HSA-8944104 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-8956365 ( R-HSA-4551638 ) R-HSA-8956365 Reaction Name: ZBED1 (DREF) SUMOylates CHD3 with SUMO1 See in Reactome R-HSA-9679787 ( R-HSA-3214815 ) R-HSA-9679787 Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors See in Reactome

Number of enzymes:	7
Number of disease:	29
Number of reactomes:	88
Number of reactions:	247

Search summary (Reactome ID: R-HSA-6804758)

Search results (Reactome ID: R-HSA-6804758)

MONDO:0000087

R-HSA-9634638

R-HSA-9607240

R-HSA-198693

R-HSA-8948751

R-HSA-111447

R-HSA-1257604

R-HSA-389513

R-HSA-199418

R-HSA-211163

R-HSA-389357

R-HSA-5628897

R-HSA-8941332

R-HSA-6804759

R-HSA-6804758

R-HSA-6804757

R-HSA-9614399

R-HSA-392451

R-HSA-198323

R-HSA-8876198

R-HSA-1358803

R-HSA-69656

R-HSA-69202

R-HSA-5218920

R-HSA-3700989

R-HSA-210745

R-HSA-6806003

R-HSA-168256

R-HSA-1280215

R-HSA-9006925

R-HSA-1640170

R-HSA-1280218

R-HSA-1266738

R-HSA-73857

R-HSA-5633007

R-HSA-194138

R-HSA-74160

R-HSA-8863795

R-HSA-9614085

R-HSA-69278

R-HSA-389356

R-HSA-162582

R-HSA-388841

R-HSA-9007101

R-HSA-453279

R-HSA-4420097

R-HSA-388396

R-HSA-199991

R-HSA-9006931

R-HSA-8939211

R-HSA-9009391

R-HSA-5653656

R-HSA-186712

R-HSA-372790

R-HSA-114452

R-HSA-69206

R-HSA-6807070

R-HSA-5357801

R-HSA-397795

R-HSA-69242

R-HSA-212436

R-HSA-8878166

R-HSA-1227986

R-HSA-9006934

R-HSA-109606

R-HSA-109581

R-HSA-1358791

R-HSA-198270

R-HSA-198298

R-HSA-198347

R-HSA-198371

R-HSA-198599

R-HSA-198609

R-HSA-198611

R-HSA-198613

R-HSA-198621

R-HSA-198640

R-HSA-199298